Nonsteroidal Anti-Inflammatory Drugs

  • Leslie J. Crofford


  • ■Nonsteriodal anti-inflammatory drugs (NSAIDs) relieve inflammation and pain by inhibiting the production of prostaglandins.

  • ■Prostaglandin (PG) biosynthesis occurs via a three-enzyme cascade. Current NSAIDs inhibit the enzyme cyclooxygenase (COX), accounting for their efficacy and toxicity.

  • ■Pharmacologic properties of the different NSAIDs, including specificity for COX-1 or -2 and drug half-life, influence the toxicity profile.

  • ■The most important NSAID toxicities include gastrointestinal ulceration, asthma and allergic reactions, and effects on the kidneys, liver, and cardiovascular system.

  • ■Safe use of NSAIDs requires consideration of indi vidual comorbidities to choose the best agent, appropriate monitoring for toxicity, and use of appropriate gastroprotective agents.


Sodium Salicylate Rheumatoid Arthri Choline Magnesium Trisalicylate Fenamic Acid Choline Salicylate 
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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Leslie J. Crofford
    • 1
  1. 1.Division of Rheumatology & Women’s HealthUniversity of KentuckyLexingtonUSA

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