Psoriatic Arthritis

  • Dafna D. Gladman


Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis (1). Psoriasis is an inflammatory skin condition that presents with a red scaly rash often on the extensor surfaces but may also affect the scalp and flexural areas as well as palms and soles (2). It commonly affects the nails with either pits or onycholysis. Up to one third of patients with psoriasis may develop an inflammatory arthritis presenting with pain and stiffness in the affected joints. Both psoriasis and PsA affect men and women equally. PsA was distinguished from rheumatoid arthritis (RA), the prototype inflammatory arthritis, in the middle of the past century with the discovery of rheumatoid factor (RF). Whereas 85% of patients with RA are RF positive, patients with psoriatic arthritis are usually seronegative for RF. Earlier studies using the latex fixation test suggested that up to 15% of patients with PsA were seropositive (3), but more recent studies using either nephelometry or enzyme-linked immunosorbent assay (ELISA) tests reveal a prevalence of only 4% to 5% (4).


Rheumatoid Arthritis Human Leukocyte Antigen Major Histocompatibility Complex Class Rheumatoid Factor Psoriatic Arthritis 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Dafna D. Gladman
    • 1
    • 2
    • 3
  1. 1.Department of Medicine/RheumatologyUniversity of TorontoTorontoCanada
  2. 2.Toronto Western Research InstituteTorontoCanada
  3. 3.Psoriatic Arthritis Program, University Health NetworkTorontoCanada

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