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Psoriatic Arthritis

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Primer on the Rheumatic Diseases

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Abstract

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis (1). Psoriasis is an inflammatory skin condition that presents with a red scaly rash often on the extensor surfaces but may also affect the scalp and flexural areas as well as palms and soles (2). It commonly affects the nails with either pits or onycholysis. Up to one third of patients with psoriasis may develop an inflammatory arthritis presenting with pain and stiffness in the affected joints. Both psoriasis and PsA affect men and women equally. PsA was distinguished from rheumatoid arthritis (RA), the prototype inflammatory arthritis, in the middle of the past century with the discovery of rheumatoid factor (RF). Whereas 85% of patients with RA are RF positive, patients with psoriatic arthritis are usually seronegative for RF. Earlier studies using the latex fixation test suggested that up to 15% of patients with PsA were seropositive (3), but more recent studies using either nephelometry or enzyme-linked immunosorbent assay (ELISA) tests reveal a prevalence of only 4% to 5% (4).

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Authors and Affiliations

  1. Department of Medicine/Rheumatology, University of Toronto, Toronto, Canada

    Dafna D. Gladman MD,FRCPC (Professor, Senior Scientist, Director)

  2. Toronto Western Research Institute, Toronto, Canada

    Dafna D. Gladman MD,FRCPC (Professor, Senior Scientist, Director)

  3. Psoriatic Arthritis Program, University Health Network, Toronto, Canada

    Dafna D. Gladman MD,FRCPC (Professor, Senior Scientist, Director)

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  1. Dafna D. Gladman MD,FRCPC
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Editors and Affiliations

  1. Arthritis Foundation, Atlanta, GA, USA

    John H. Klippel MD (President and CEO) (President and CEO)

  2. Massachusetts General Hospital, Boston, MA, USA

    John H. Stone MD, MPH (Associate Physician, Deputy Editor for Rheumatology) (Associate Physician, Deputy Editor for Rheumatology)

  3. Division of Rheumatology & Women’s Health, University of Kentucky, Lexington, KY, USA

    Leslie J. Crofford MD (Gloria W. Singletary Professor of Internal Medicine, Chief) (Gloria W. Singletary Professor of Internal Medicine, Chief)

  4. Arthritis Foundation, Atlanta, GA, USA

    Patience H. White MD, MA (Chief Public Health Officer) (Chief Public Health Officer)

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Gladman, D.D. (2008). Psoriatic Arthritis. In: Klippel, J.H., Stone, J.H., Crofford, L.J., White, P.H. (eds) Primer on the Rheumatic Diseases. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68566-3_8

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