Paget’s disease affects 1% of the US population over the age of 40 years and is a chronic disorder of adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with softened and enlarged bone.
Most adults with Paget’s disease are asymptomatic and diagnosis is found on x-ray of the bones.
Bone pain, fracture, and nerve impingement can occur due to enlarging and poorly constructed bone matrix.
■ Potent and generally safe suppressive agents have been developed and have resulted in a more aggressive approach to therapy.
KeywordsHearing Loss Zoledronic Acid Bone Pain Salmon Calcitonin Disodium Etidronate
Unable to display preview. Download preview PDF.
- 5.Woo S-B, Hellstein JW, Kalmar JR. Systematic review: bisphosphonates and osteonecrosis of the jaw. Ann Intern Med 2006;144:753–761.Google Scholar