Less Common Arthropathies

F. Hypertrophic Osteoarthropathy
  • Manuel Martinez-Lavin


  • Hypertrophic osteoarthropathy is characterized by abnormal proliferation of skin and bone at the distal parts of the extremities.

  • Clinical features include bulbous deformity of the tips of the digits (conventionally known as clubbing) and periostosis of the tubular bones.

  • The development of hypertrophic osteoarthropathy may indicate the presence of a significant internal illness, often a pulmonary malignancy or inflammatory disease of the lung.

  • ■ Abnormal vascular endothelial growth factor expression may play a central role in the pathogenesis of this condition.


Vascular Endothelial Growth Factor Infective Endocarditis Vascular Endothelial Growth Factor Expression Tubular Bone Poem Syndrome 


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Manuel Martinez-Lavin
    • 1
  1. 1.Department of RheumatologyNational Institute of CardiologyMexicoMexico

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