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Periodic Syndromes

  • John G. Ryan
  • Daniel L. Kastner

Abstract

  • Hereditary periodic fever syndromes are autoinflammatory diseases characterized by episodes of fever with serosal, synovial, and/or skin inflammation.

  • Familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D with periodic fever syndrome (HIDS) are inherited in an autosomal recessive manner and tumor necrosis factor receptor-associated periodic syndrome (TRAPS), familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID) are dominantly inherited.

  • ■ Colchicine and biologic therapies such as tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) receptor agonists are successful in the treatment of some of these inherited diseases.

Keywords

Familial Mediterranean Fever Familial Mediterranean Fever Patient MEFV Mutation Periodic Syndrome Periodic Fever Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • John G. Ryan
    • 1
    • 2
  • Daniel L. Kastner
    • 3
  1. 1.Genetics and Genomics BranchBethesdaUSA
  2. 2.Genetics and Genomics BranchNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaUSA
  3. 3.National Institute of Arthritis and Musculoskeletal and Skin DiseasesBethesdaUSA

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