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Adult-Onset Still’s Disease

  • John M. Esdaile

Abstract

  • Diagnosis is one of exclusion and is suggested by the characteristic febrile pattern, evanescent rash, organomegaly, elevated white blood cell count, and a markedly elevated serum ferritin, serum IL-18 when available, and a reduced glycosylated fraction of ferritin.

  • A predominance of T-helper cell (Th1) cytokines such as interleukin (IL)-2, IL-6, IL-18, interferon gamma, tumor necrosis factor (TNF) alpha have been reported in persons with active adult Still’s disease and therapy against these cytokines is an active area of investigation.

  • ■ Most have a chronic course with morbidity arising from a polyarthritis.

Keywords

Lyme Disease Thrombotic Thrombocytopenic Purpura Juvenile Rheumatoid Arthritis Mixed Connective Tissue Disease Elevated White Blood Cell Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • John M. Esdaile
    • 1
    • 2
  1. 1.University of British ColumbiaVancouverCanada
  2. 2.Arthritis Research Centre of CanadaVancouverCanada

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