Adult-Onset Still’s Disease

  • John M. Esdaile


  • Diagnosis is one of exclusion and is suggested by the characteristic febrile pattern, evanescent rash, organomegaly, elevated white blood cell count, and a markedly elevated serum ferritin, serum IL-18 when available, and a reduced glycosylated fraction of ferritin.

  • A predominance of T-helper cell (Th1) cytokines such as interleukin (IL)-2, IL-6, IL-18, interferon gamma, tumor necrosis factor (TNF) alpha have been reported in persons with active adult Still’s disease and therapy against these cytokines is an active area of investigation.

  • ■ Most have a chronic course with morbidity arising from a polyarthritis.


Lyme Disease Thrombotic Thrombocytopenic Purpura Juvenile Rheumatoid Arthritis Mixed Connective Tissue Disease Elevated White Blood Cell Count 
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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • John M. Esdaile
    • 1
    • 2
  1. 1.University of British ColumbiaVancouverCanada
  2. 2.Arthritis Research Centre of CanadaVancouverCanada

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