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Relapsing Polychondritis

  • Harvinder S. Luthra

Abstract

  • Relapsing polychondritis (RP) is a rare disease that occurs worldwide in all age groups and affects men and women equally.

  • An associated rheumatologic or hematologic disorder is seen in over 30% of patients with RP. Inflammation of cartilaginous structures with lymphocytic infiltration and association with anticollagen antibodies are consistent with an autoimmune pathogenesis.

  • The characteristic clinical findings are acute painful swelling and redness of the external ear, nasal cartilage, and laryngotracheal cartilage. Nonerosive arthritis, ocular inflammation, vestibular symptoms, and involvement of the heart and kidney also occur.

  • Diagnosis is made on clinical grounds, though cartilage biopsy may be useful.

  • Treatment with nonsteriodal anti-inflammatory drugs (NSAIDs) or corticosteroids may control inflammation, but immunosuppressive and biologic treatments may be required for severe disease.

  • ■ Laryngotracheal involvement is a serious complication that may require tracheostomy.

Keywords

Aortic Valve Disease Relapse Polychondritis Retinal Vasculitis Large Vessel Disease Nasal Cartilage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Harvinder S. Luthra
    • 1
  1. 1.Department of RheumatologyMayo Clinic College of MedicineRochesterUSA

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