Sjögren’s Syndrome

  • Troy Daniels


  • Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with early and gradually progressive lacrimal and salivary dysfunction.

  • Secondary SS occurs in association with other autoimmune disorders, the most common of which is rheumatoid arthritis.

  • Minor salivary glands and lacrimal glands in SS exhibit a particular pattern of periductal lymphocytic infiltration known as focal lymphocytic sialadenitis.

  • About 90% of patients with SS are women.

  • Sjögren’s syndrome is very common, with a community prevalence of pSS ranging from 0.1% to 0.6% of all individuals.

  • The major eye problem in SS is keratoconjunctivitis sicca, leading to xerophthalmia. The principal oral manifestation of SS is decreased salivary gland production, leading to xerostomia and a predilection for dental caries.

  • Extraglandular manifestations of SS include arthralgias, thyroiditis, renal involvement (leading to renal tubular acidosis), peripheral neuropathy, cutaneous vasculitis, and lymphoma.

  • The risk of lymphoma in pSS is approximately 5%.

  • Most patients with SS develop increased circulating polyclonal immunoglobulins and autoantibodies. These autoantibodies include two fairly specific antibodies directed against the Ro (SS-A) and La (SS-B) antigens.

  • ■ Anti-Ro and -La antibodies may be associated with fetal heart block during the pregnancies of women with SS.


Salivary Gland Minor Salivary Gland Cutaneous Vasculitis Congenital Heart Block Oral Symptom 
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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Troy Daniels
    • 1
  1. 1.Schools of Dentistry and MedicineUniversity of California, San FranciscoSan FranciscoUSA

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