Antiphospholipid Syndrome

  • Michelle Petri


Antiphospholipid antibodies (aPL) are autoantibodies directed against negatively charged phospholipid/plasma proteins. The most common plasma protein target is beta 2 glycoprotein I. The three most im-portant antiphospholipid antibodies are the lupus anti-coagulant, anticardiolipin, and anti–beta 2 glycoprotein I.

Antiphospholipid syndrome (APS) is one of the most common acquired causes of hypercoagulability. Fifty percent of APS patients have systemic lupus erythe-matosus (SLE). APS presents in two major ways: thrombosis (venous or arterial) and pregnancy loss. Thrombocytopenia, present in about 20% of cases, can be an important clue.


Systemic Lupus Erythematosus International Normalize Ratio Systemic Lupus Erythematosus Patient Pregnancy Loss Arterial Thrombosis 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Michelle Petri
    • 1
  1. 1.Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA

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