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Antiphospholipid Syndrome

  • Michelle Petri

Abstract

Antiphospholipid antibodies (aPL) are autoantibodies directed against negatively charged phospholipid/plasma proteins. The most common plasma protein target is beta 2 glycoprotein I. The three most im-portant antiphospholipid antibodies are the lupus anti-coagulant, anticardiolipin, and anti–beta 2 glycoprotein I.

Antiphospholipid syndrome (APS) is one of the most common acquired causes of hypercoagulability. Fifty percent of APS patients have systemic lupus erythe-matosus (SLE). APS presents in two major ways: thrombosis (venous or arterial) and pregnancy loss. Thrombocytopenia, present in about 20% of cases, can be an important clue.

Keywords

Systemic Lupus Erythematosus International Normalize Ratio Systemic Lupus Erythematosus Patient Pregnancy Loss Arterial Thrombosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Michelle Petri
    • 1
  1. 1.Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA

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