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Regulation of Neuronal Morphogenesis by Abl Family Kinases

  • Hameeda Sultana
  • Anthony J. Koleske

Keywords

Growth Cone Dendrite Arbor Commissural Axon Neuronal Morphogenesis Lamellipodial Protrusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bashaw, G.J., Kidd, T., Murray, D., Pawson, T., and Goodman, C.S., 2000, Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor, Cell 101: 703–715.PubMedCrossRefGoogle Scholar
  2. Bennett, R.L., and Hoffmann, F.M., 1992, Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: Subcellular localization and mutant phenotypes imply a role in cell–cell interactions, Development 116: 953–966.PubMedGoogle Scholar
  3. Billuart, P., Winter, C.G., Maresh, A., Zhao, X., and Luo, L., 2001, Regulating axon branch stability: The role of p190 RhoGAP in repressing a retraction signaling pathway, Cell 107: 195–207.PubMedCrossRefGoogle Scholar
  4. Clegg, D.O., Wingerd, K.L., Hikita, S.T., and Tolhurst, E.C., 2003, Integrins in the development, function and dysfunction of the nervous system, Front. Biosci. 8: d723–d750.PubMedCrossRefGoogle Scholar
  5. Comer, A.R., Ahern-Djamali, S.M., Juang, J.L., Jackson, P.D., and Hoffmann, F.M., 1998, Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein–protein interactions of Enabled, Mol. Cell. Biol. 18: 152–160.PubMedGoogle Scholar
  6. DeMali, K.A., Wennerberg, K., and Burridge, K., 2003, Integrin signaling to the actin cytoskeleton, Curr. Opin. Cell Biol. 15: 572–582.PubMedCrossRefGoogle Scholar
  7. Elkins, T., Zinn, K., McAllister, L., Hoffmann, F.M., and Goodman, C.S. (1990). Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565–575.PubMedCrossRefGoogle Scholar
  8. Forsthoefel, D.J., Liebl, E.C., Kolodziej, P.A., and Seeger, M.A., 2005, The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila, Development 132: 1983–1994.PubMedCrossRefGoogle Scholar
  9. Gertler, F.B., Bennett, R.L., Clark, M.J., and Hoffmann, F.M., 1989, Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled, Cell 58: 103–113.PubMedCrossRefGoogle Scholar
  10. Gertler, F.B., Comer, A.R., Juang, J.L., Ahern, S.M., Clark, M.J., Liebl, E.C., and Hoffmann, F.M. (1995). Enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev 9: 521–533.PubMedCrossRefGoogle Scholar
  11. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., and Soriano, P., 1996, Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics, Cell 87: 227–239.PubMedCrossRefGoogle Scholar
  12. Harbott, L.K., and Nobes, C.D. (2005). A key role for Abl family kinases in EphA receptor-mediated growth cone collapse. Mol Cell Neurosci 30: 1–11.PubMedCrossRefGoogle Scholar
  13. Hernandez, S.E., Settleman, J., and Koleske, A.J., 2004, Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase, Curr. Biol. 14: 691–696.PubMedCrossRefGoogle Scholar
  14. Hoang, B., and Chiba, A., 1998, Genetic analysis on the role of integrin during axon guidance in Drosophila, J. Neurosci. 18: 7847–7855.PubMedGoogle Scholar
  15. Hsouna, A., Kim, Y.S., and VanBerkum, M.F., 2003, Abelson tyrosine kinase is required to transduce midline repulsive cues, J. Neurobiol. 57: 15–30.PubMedCrossRefGoogle Scholar
  16. Hynes, R.O., 2002, Integrins: Bidirectional, allosteric signaling machines, Cell 110: 673–687.PubMedCrossRefGoogle Scholar
  17. Jalali, S., del Pozo, M.A., Chen, K., Miao, H., Li, Y., Schwartz, M.A., Shyy, J.Y., and Chien, S., 2001, Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands, Proc. Natl. Acad. Sci. USA 98: 1042–1046.PubMedCrossRefGoogle Scholar
  18. Jones, S.B., Lu, H.Y., and Lu, Q., 2004, Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons, J. Neurosci. 24: 8510–8521.PubMedCrossRefGoogle Scholar
  19. Kaibuchi, K., Kuroda, S., and Amano, M., 1999, Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells, Annu. Rev. Biochem. 68: 459–486.PubMedCrossRefGoogle Scholar
  20. Koch, A., Mancini, A., Stefan, M., Niedenthal, R., Niemann, H., and Tamura, T. (2000). Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. FEBS Lett 469: 72–76.PubMedCrossRefGoogle Scholar
  21. Krause, M., Dent, E.W., Bear, J.E., Loureiro, J.J., and Gertler, F.B., 2003, Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration, Annu. Rev. Cell Dev. Biol. 19: 541–564.PubMedCrossRefGoogle Scholar
  22. Lanier, L.M., and Gertler, F.B., 2000, From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility, Curr. Opin. Neurobiol. 10: 80–87.PubMedCrossRefGoogle Scholar
  23. Lebrand, C., Dent, E.W., Strasser, G.A., Lanier, L.M., Krause, M., Svitkina, T.M., et al., 2004, Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1, Neuron 42: 37–49.PubMedCrossRefGoogle Scholar
  24. Lee, T., Winter, C., Marticke, S.S., Lee, A., and Luo, L., 2000, Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis, Neuron 25: 307–316.PubMedCrossRefGoogle Scholar
  25. Lee, H., Engel, U., Rusch, J., Scherrer, S., Sheard, K., and Van Vactor, D., 2004, The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance, Neuron 42: 913–926.PubMedCrossRefGoogle Scholar
  26. Lewis, J.M., Baskaran, R., Taagepera, S., Schwartz, M.A., and Wang, J.Y., 1996, Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport, Proc. Natl. Acad. Sci. USA 93: 15174–15179.PubMedCrossRefGoogle Scholar
  27. Li, W., Li, Y., and Gao, F.B., 2005, Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila, Dev. Dyn. 234: 512–522.PubMedCrossRefGoogle Scholar
  28. Li, Z., Aizenman, C.D., and Cline, H.T., 2002, Regulation of rho GTPases by crosstalk and neuronal activity in vivo, Neuron 33: 741–750.PubMedCrossRefGoogle Scholar
  29. Liebl, E.C., Forsthoefel, D.J., Franco, L.S., Sample, S.H., Hess, J.E., Cowger, J.A., et al., 2000, Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding, Neuron 26: 107–118.PubMedCrossRefGoogle Scholar
  30. Lohmann, C., Myhr, K.L., and Wong, R.O., 2002, Transmitter-evoked local calcium release stabilizes developing dendrites, Nature 418: 177–181.PubMedCrossRefGoogle Scholar
  31. Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N., 1996, Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines, Nature 379: 837–840.PubMedCrossRefGoogle Scholar
  32. Master, Z., Tran, J., Bishnoi, A., Chen, S.H., Ebos, J.M., Van Slyke, P., et al., 2003, Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization, J. Biol. Chem. 278: 30170–30179.PubMedCrossRefGoogle Scholar
  33. McAllister, A.K., 2000, Cellular and molecular mechanisms of dendrite growth, Cereb. Cortex 10: 963–973.PubMedCrossRefGoogle Scholar
  34. McWhirter, J.R., and Wang, J.Y., 1993, An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias, EMBO J. 12: 1533–1546.PubMedGoogle Scholar
  35. Miao, Y.J., and Wang, J.Y., 1996, Binding of A/T-rich DNA by three high mobility group-like domains in c-Abl tyrosine kinase, J. Biol. Chem. 271: 22823–22830.PubMedCrossRefGoogle Scholar
  36. Miller, A.L., Wang, Y., Mooseker, M.S., and Koleske, A.J., 2004, The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion, J. Cell Biol. 165: 407–419.PubMedCrossRefGoogle Scholar
  37. Moresco, E.M., Donaldson, S., Williamson, A., and Koleske, A.J., 2005, Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases, J. Neurosci. 25: 6105–6118.PubMedCrossRefGoogle Scholar
  38. Nakayama, A.Y., Harms, M.B., and Luo, L., 2000, Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons, J. Neurosci. 20: 5329–5338.PubMedGoogle Scholar
  39. Pendergast, A.M., 2002, The Abl family kinases: Mechanisms of regulation and signaling, Adv. Cancer Res. 85: 51–100.PubMedCrossRefGoogle Scholar
  40. Pinkstaff, J.K., Detterich, J., Lynch, G., and Gall, C., 1999, Integrin subunit gene expression is regionally differentiated in adult brain, J. Neurosci. 19: 1541–1556.PubMedGoogle Scholar
  41. Redmond, L., Kashani, A.H., and Ghosh, A., 2002, Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription, Neuron 34: 999–1010.PubMedCrossRefGoogle Scholar
  42. Reichardt, L.F., and Tomaselli, K.J., 1991, Extracellular matrix molecules and their receptors: Functions in neural development, Annu. Rev. Neurosci. 14: 531–570.PubMedCrossRefGoogle Scholar
  43. Rhee, J., Mahfooz, N.S., Arregui, C., Lilien, J., Balsamo, J., and VanBerkum, M.F. (2002). Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion. Nat Cell Biol 4: 798–805.PubMedCrossRefGoogle Scholar
  44. Rivero-Lezcano, O.M., Marcilla, A., Sameshima, J.H., and Robbins, K., 1995, Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains, Mol. Cell Biol. 15: 5725–5731.PubMedGoogle Scholar
  45. Rohatgi, R., Nollau, P., Ho, H.Y., Kirschner, M.W., and Mayer, B.J., 2001, Nck and phosphatidylinositol 4, 5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway, J. Biol. Chem. 27: 26448–26452.CrossRefGoogle Scholar
  46. Ruchhoeft, M.L., Ohnuma, S., McNeill, L., Holt, C.E., Harris, W.A., 1999, The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo, J. Neurosci. 19: 8454–8463.PubMedGoogle Scholar
  47. Schmid, R.S., and Anton, E.S., 2003, Role of integrins in the development of the cerebral cortex, Cereb. Cortex 13: 219–224.PubMedCrossRefGoogle Scholar
  48. Schwartz, M.A., 2001, Integrin signaling revisited, Trends Cell Biol. 11: 466–470.PubMedCrossRefGoogle Scholar
  49. Schwartz, M.A., Schaller, M.D., and Ginsberg, M.H., 1995, Integrins: Emerging paradigms of signal transduction, Annu. Rev. Cell Dev. Biol. 11: 549–599.PubMedCrossRefGoogle Scholar
  50. Suter, D.M., Schaefer, A.W., and Forscher, P., 2004, Microtubule dynamics are necessary for SRC family kinase-dependent growth cone steering, Curr. Biol. 14: 1194–1199.PubMedCrossRefGoogle Scholar
  51. Tanaka, E., and Kirschner, M.W., 1995, The role of microtubules in growth cone turning at substrate boundaries, J. Cell Biol. 128: 127–137.PubMedCrossRefGoogle Scholar
  52. Tashiro, A., Minden, A., and Yuste, R., 2000, Regulation of dendritic spine morphology by the rho family of small GTPases: Antagonistic roles of Rac and Rho, Cereb. Cortex 10: 927–938.PubMedCrossRefGoogle Scholar
  53. Vaillant, A.R., Zanassi, P., Walsh, G.S., Aumont, A., Alonso, A., and Miller, F.D., 2002, Signaling mechanisms underlying reversible, activity-dependent dendrite formation, Neuron 34: 985–998.PubMedCrossRefGoogle Scholar
  54. Van Etten, R.A., Jackson, P.K., Baltimore, D., Sanders, M.C., Matsudaira, P.T., and Janmey, P.A., 1994, The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity, J. Cell Biol. 124: 325–340.PubMedCrossRefGoogle Scholar
  55. Wen, S.T., Jackson, P.K., and Van Etten, R.A., 1996, The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products, EMBO J. 15: 1583–1595.PubMedGoogle Scholar
  56. Whitford, K.L., Dijkhuizen, P., Polleux, F., and Ghosh, A., 2002, Molecular control of cortical dendrite development, Annu. Rev. Neurosci. 25: 127–149.PubMedCrossRefGoogle Scholar
  57. Wills, Z., Bateman, J., Korey, C.A., Comer, A., and Van Vactor, D., 1999a, The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance, Neuron, 22: 301–312.PubMedCrossRefGoogle Scholar
  58. Wills, Z., Marr, L., Zinn, K., Goodman, C.S., and Van Vactor, D., 1999b, Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo, Neuron 22: 291–299.CrossRefGoogle Scholar
  59. Wills, Z., Emerson, M., Rusch, J., Bikoff, J., Baum, B., Perrimon, N., et al., 2002, A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding, Neuron 36: 611–622.PubMedCrossRefGoogle Scholar
  60. Woodring, P.J., Hunter, T., and Wang, J.Y., 2001, Inhibition of c-Abl tyrosine kinase activity by filamentous actin, J. Biol. Chem. 276: 27104–27110.PubMedCrossRefGoogle Scholar
  61. Woodring, P.J., Litwack, E.D., O'Leary, D.D., Lucero, G.R., Wang, J.Y., and Hunter, T., 2002, Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension, J. Cell Biol. 156: 879–892.PubMedCrossRefGoogle Scholar
  62. Woodring, P.J., Meisenhelder, J., Johnson, S.A., Zhou, G.L., Field, J., Shah, K., et al., 2004, c-Abl phosphorylates Dok1 to promote filopodia during cell spreading, J. Cell Biol. 165: 493–503.PubMedCrossRefGoogle Scholar
  63. Yano, H., Cong, F., Birge, R.B., Goff, S.P., and Chao, M.V. (2000). Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. J Neurosci Res 59: 356–364.PubMedCrossRefGoogle Scholar
  64. Yu, H.H., Zisch, A.H., Dodelet, V.C., and Pasquale, E.B. (2001). Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene 20: 3995–4006.PubMedCrossRefGoogle Scholar
  65. Zhao, Z.S., Manser, E., and Lim, L., 2000, Interaction between PAK and nck: A template for Nck targets and role of PAK autophosphorylation, Mol. Cell Biol. 20: 3906–3917.PubMedCrossRefGoogle Scholar
  66. Zukerberg, L.R., Patrick, G.N., Nikolic, M., Humbert, S., Wu, C.L., Lanier, L.M., et al., 2000, Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth, Neuron 26: 633–646.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Hameeda Sultana
    • 1
  • Anthony J. Koleske
    • 2
  1. 1.Department of Molecular Biophysics and BiochemistryYale University SHMC-E30New HavenUSA
  2. 2.Department of Molecular Biophysics and Biochemistry, Department of NeurobioYale University SHMC-E30New HavenUSA

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