Prion proteins and prion diseases

  • Engelbert Buxbaum


The so called prion diseases (for more details see [40]) result in destruction of the brain, this is eventually fatal. The first such disease described (in the 18th century) was scrapie in sheeps. It was noted that this disease could be spread to other animal species by feeding them infected brain. One of the most remarkable features of the infectious agent of scrapie is its incredible resistance to destruction. A sheep head, buried for three years, proved still infectious when fed to mice. The agent can not be inactivated with formalin (methanal), with UV light or by heat sterilisation.


Prion Protein Prion Disease Bone Meal Fatal Familial Insomnia Prion Protein Scrapie 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Engelbert Buxbaum
    • 1
  1. 1.Department of BiochemistryRoss University School of MedicineWest Indies

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