Deformable Model-Based Image Registration

  • Jundong Liu
Part of the Topics in Biomedical Engineering. International Book Series book series (ITBE)

In this chapter we introduce the concept of deformable image registration and point out that interpolation effects, non-rigid body registration, and joint segmentation and registration frameworks are among the challenges that remain for this area. To address the interpolation effects challenge, we choose the Partial Volume Interpolator (PV) used in multimodality registration as an example, and quantitatively analyze the generation mechanism of the interpolation artifacts. We conclude that the combination of linear interpolation kernel and translation-only motion leads to generation of the artifact pattern. As a remedy we propose to use nonuniform interpolation functions in estimating the joint histogram. The cubic B-spline and Gaussian interpolators are compared, and we demonstrate improvements via experiments on misalignments between CT/MR brain scans. A segmentation-guided non-rigid registration framework is proposed to address the second and third challenges. Our approach integrates the available prior shape information as an extra force to lead to a noise-tolerant registration procedure, and it differs from other methods in that we use a unified segmentation + registration energy minimization formulation, and the optimization is carried out under the level-set framework. We show the improvement accomplished with our model by comparing the results with that of the Demons algorithm. To explore other similarity metrics under the same framework to handle more complicated inputs will be the focus of our future work.


Mutual Information Image Registration Registration Result Joint Entropy Deformable Image Registration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jundong Liu
    • 1
  1. 1.School of Electrical Engineering and Computer ScienceOhio UniversityAthensUSA

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