Physical and Psychosocial Issues in Lung Cancer Survivors

  • Linda Sarna
  • Frederic W. GrannisJr.
  • Anne Coscarelli


Lung cancer emerged during the 20th century as an epidemic of enormous proportions.1 A rare disease at the beginning of the past century, lung cancer continues to be one of the most common cancers in the world, affecting 174,470 Americans (92,700 men and 81,770 women) in 2006.2 Mirroring changes in smoking patterns, the incidence of lung cancer among men continues to decline. Large-scale smoking among women occurred almost 20 years after men in the United States, with a subsequent delay in increased cases, peaking in the 1990s. Encouragingly, the most recent evidence demonstrates that lung cancer incidence among women is declining, as are death rates.3 In 2000, approximately 13% of men and 17% of women (age-adjusted, 15% overall) diagnosed with lung cancer were expected to survive at least 5 years (an estimated 26,065 Americans each year).2


Lung Cancer Cell Lung Cancer Smoking Cessation Clin Oncol Small Cell Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Centers for Disease Control. Ten great public health achievements—United States, 1900–1999. MMWR (Morb Mortal Wkly Rep) 1999;48:241–243.Google Scholar
  2. 2.
    Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun MJ. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106–130.PubMedGoogle Scholar
  3. 3.
    Jemal A, Clegg LX, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer (Phila) 2004;101:3–27.PubMedCrossRefGoogle Scholar
  4. 4.
    Carlens EDG, Nou E. Comparative measurements of quality of survival of lung cancer patients after diagnosis. Scand J Respir Dis 1970;51:268–275.PubMedGoogle Scholar
  5. 5.
    Carlens EDG, Nou E. An attempt to include “quality of life” in evaluation of survival in bronchial cancer therapy. Bronches 1971;21:215–219.PubMedGoogle Scholar
  6. 6.
    Sarna L, Reidinger MS. Assessment of quality of life and symptom improvement in lung cancer clinical trials. Semin Oncol 2004;31(suppl 9):1–10.PubMedCrossRefGoogle Scholar
  7. 7.
    Montazeri A, Gillis CR, McEwen J. Quality of life in patients with lung cancer: a review of literature from 1970 to 1995. Chest 1998;113:467–481.PubMedGoogle Scholar
  8. 8.
    Dales RE, Belanger R, Shamiji FM, et al. Quality of life following thoracotomy for lung cancer. J Clin Epidemiol 1994;47:1443–1449.PubMedCrossRefGoogle Scholar
  9. 9.
    Schag CAC, Ganz PA, Wing DS, et al. Quality of life in adult survivors of lung, colon and prostate cancer. Qual Life Res 1994;3:127–141.PubMedCrossRefGoogle Scholar
  10. 10.
    Sarna L, Padilla G, Holmes C, et al. Quality of life of long-term survivors of non-small cell lung cancer. J Clin Oncol 2002;20:2920–2929.PubMedCrossRefGoogle Scholar
  11. 11.
    Sarna L, Evangelista L, Tashkin D, et al. Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer. Chest 2004;125:439–445.PubMedCrossRefGoogle Scholar
  12. 12.
    Maliski SL, Sarna L, Evangelista L, et al. The aftermath of lung cancer: balancing the good and bad. Cancer Nurs 2003;26:237–244.PubMedCrossRefGoogle Scholar
  13. 13.
    Evangelista LS, Sarna L, Brecht ML, et al. Health perceptions and risk behaviors of lung cancer survivors. Heart Lung 2003;32:131–139.PubMedCrossRefGoogle Scholar
  14. 14.
    Uchitomi Y, Mikami I, Kugaya A, et al. Depression after successful treatment for nonsmall cell lung carcinoma. A 3-month follow-up study. Cancer (Phila) 2000;89:1172–1179.PubMedCrossRefGoogle Scholar
  15. 15.
    Motohiro A, Ueda H, Komatsu H, et al. Prognosis of non-surgically treated, clinical stage I lung cancer patients in Japan. Lung Cancer 2002;36:65–69.PubMedCrossRefGoogle Scholar
  16. 16.
    McGarry RC, Song G, des Rosiers P, et al. Observation-only management of early stage, medically inoperable lung cancer: poor outcome. Chest 2002;2002:1155–1158.CrossRefGoogle Scholar
  17. 17.
    Tai THP, Yu E, Dickof P, et al. Prophylactic cranial irradiation revisited: cost-effectiveness and quality of life in small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002;52:68–74.PubMedCrossRefGoogle Scholar
  18. 18.
    Fuentes PA. Pneumonectomy: historical perspective and prospective insight. Eur J Cardiothorac Surg 2003;23:439–445.PubMedCrossRefGoogle Scholar
  19. 19.
    Ferguson MK, Lehman AG. Sleeve lobectomy or pneumonectomy: optimal management strategy using decision analysis techniques. Ann Thorac Surg 2003;76:1782–1788.PubMedCrossRefGoogle Scholar
  20. 20.
    De Leyn P, Rots W, Deneffe G, et al. Sleeve lobectomy for nonsmall cell lung cancer. Acta Chir Belg 2003;103:570–576.PubMedGoogle Scholar
  21. 21.
    Pompeo E, De Dominicis E, Ambrogi V, et al. Quality of life after tailored combined surgery for stage 1 non-small-cell lung cancer and severe emphysema. Ann Thorac Surg 2003;76:1821–1827.PubMedCrossRefGoogle Scholar
  22. 22.
    Montazeri A, Milroy R, Hole D, et al. Anxiety and depression in patients with lung cancer before and after diagnosis: findings from a population in Glasgow, Scotland. J Epidemiol Community Health 1998;52(3):203–204.PubMedGoogle Scholar
  23. 23.
    Hendriks J, Van Schil P, Van Meerbeeck J, et al. Short-term survival after major pulmonary resections for bronchogenic carcinoma. Acta Chir Belg 1996;96:273–279.PubMedGoogle Scholar
  24. 24.
    Cooley M. Patterns of symptom distress in adults receiving treatment for lung cancer. J Palliat Care 2002;18:150–159.PubMedGoogle Scholar
  25. 25.
    Pelkonen M, Notkola I-L, Tukianinen H, et al. Smoking cessation, decline in pulmonary function and total mortality: a 30 year follow up study among the Finnish cohorts of the Seven Counties Study. Thorax 2001;56:703–707.PubMedCrossRefGoogle Scholar
  26. 26.
    Nezu K, Kushibe K, Tojo T, et al. Recovery and limitation of exercise capacity after lung resection for lung cancer. Chest 1998;113:1511–1516.PubMedGoogle Scholar
  27. 27.
    Miyazawa M, Haniuda M, Nishimura H, et al. Long-term effects of pulmonary resection on cardiopulmonary function. J Am Coll Surg 1999;189:26–33.PubMedCrossRefGoogle Scholar
  28. 28.
    Larsen KR, Svendsen UG, Milman N, et al. Cardiopulmonary function at rest and during exercise for bronchial resection for bronchial carcinoma. Ann Thorac Surg 1997;64:960–964.PubMedCrossRefGoogle Scholar
  29. 29.
    Handy JR, Asaph JW, Skokan L, et al. What happens to patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgery. Chest 2002;122:21–30.PubMedCrossRefGoogle Scholar
  30. 30.
    Bolliger CT, Jordan P, Soler M, et al. Pulmonary function and exercise capacity after lung resection. Eur Respir J 1996;9:415–421.PubMedCrossRefGoogle Scholar
  31. 31.
    Bolliger CT, Zellweger JJP, Danielsson T, et al. Influence of long-term smoking reduction on health risk markers and quality of life. Nicotine Tobacco Res 2002;4:433–439.CrossRefGoogle Scholar
  32. 32.
    Nomori H, Ohtsuka T, Horio H, et al. Difference in the impairment of vital capacity and 6-minute walking after a lobectomy performed by thoracoscopic surgery, an anterior limited thoracotomy, an anteroaxillary thoracotomy, and a posterolateral thoracotomy. Surg Today 2003;33:7–12.PubMedCrossRefGoogle Scholar
  33. 33.
    Pelletier C, Lapointe L, LeBlanc P. Effects of lung resection on pulmonary function and exercise capacity. Thorax 1990;1990:497–502.Google Scholar
  34. 34.
    Zieren HU, Muller JM, Hamberger U, et al. Quality of life after surgical therapy of bronchogenic carcinoma. Eur J Cardiothorac Surg 1996;10:233–237.PubMedCrossRefGoogle Scholar
  35. 35.
    Myrdal G, Valtysdottir S, Lambe M, et al. Quality of life following lung cancer surgery. Thorax 2003;58:194–197.PubMedCrossRefGoogle Scholar
  36. 36.
    Nugent AM, Steele IC, Carragher AM, et al. Effect of thoracotomy and lung resection on exercise capacity in patients with lung cancer. Thorax 1999;54:334–338.PubMedCrossRefGoogle Scholar
  37. 37.
    Uchitomi Y, Mikami I, Nagai K, et al. Depression and psychological distress in patients during the year after curative resection of non-small cell lung cancer. J Clin Oncol 2003;21:69–77.PubMedCrossRefGoogle Scholar
  38. 38.
    Rogers ML, Duffy JP. Surgical aspects of chronic postthoracotomy pain. Eur J Cardiothorac Surg 2000;19:711–716.CrossRefGoogle Scholar
  39. 39.
    Landreneau RJ, Mack MJ, Hazelrigg SR, et al. Prevalence of chronic pain after pulmonary resection by thoracotomy or videoassisted thoracic surgery. J Cardiovasc Surg 1995;109:1085–1086.Google Scholar
  40. 40.
    Dajczman E, Gordon A, Kreisman H, et al. Long-term postthoracotomy pain. Chest 1991;99:270–274.PubMedGoogle Scholar
  41. 41.
    Sugiura H, Morikawa T, Kaji M, et al. Long-term benefits for the quality of life after video-assisted thoracoscopic lobectomy in patients with lung cancer. Surg Laparosc Endosc Percutan Tech 1999;9:403–408.PubMedCrossRefGoogle Scholar
  42. 42.
    Mangione CM, Goldman L, Orav J, et al. Health-related quality of life after elective surgery. J Gen Intern Med 1997;12:686–697.PubMedCrossRefGoogle Scholar
  43. 43.
    Gotoda Y, Kambara N, Sakai T, et al. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain 2001;5:89–96.PubMedCrossRefGoogle Scholar
  44. 44.
    Li WW, Lee TW, Lam SS, et al. Quality of life following lung cancer resection: video-assisted thoracic surgery versus thoracotomy. Chest 2002;122:584–589.PubMedCrossRefGoogle Scholar
  45. 45.
    d’Amours RH, Riegler FX, Little AG. Pathogenesis and management of persistent postthoracotomy pain. Chest Surg Clin N Am 1998;8:703–722.PubMedGoogle Scholar
  46. 46.
    Goldberg BA, Scarlat MM, Harryman DT. Management of the stiff shoulder. J Orthop Sci 1999;4:462–471.PubMedCrossRefGoogle Scholar
  47. 47.
    Cykert S, Kissling G, Hansen CJ. Patient preferences regarding possible outcomes of lung resection. Chest 2000;117:1551–1559.PubMedCrossRefGoogle Scholar
  48. 48.
    Cull A, Gregor A, Hopwood P, et al. Neurological and cognitive impairment in long-term survivors of small cell lung cancer. Eur J Cancer 1994;30A:1067–1074.PubMedCrossRefGoogle Scholar
  49. 49.
    Sarna L. Correlates of symptom distress in women with lung cancer. Cancer Pract 1993;1:21–28.PubMedGoogle Scholar
  50. 50.
    Kurz ME, Kurtz JC, Stommel M, et al. Predictors of physical functioning among geriatric patients small cell or non-small cell lung cancer 3 months after diagnosis. Support Care Cancer 1999;7:328–331.CrossRefGoogle Scholar
  51. 51.
    Schag CC, Heinrich RL. The impact of cancer on daily living. A comparison with cardiac patients and health controls. Rehabil Psychol 1986;31:157–167.CrossRefGoogle Scholar
  52. 52.
    Zebrack BJ. Cancer survivor identity and quality of life. Cancer Pract 2000;8:238–242.PubMedCrossRefGoogle Scholar
  53. 53.
    Zabora J, Brintzenhofeszoc K, Curbow B, et al. The prevalence of psychological distress by cancer site. Psycho-Oncology 2001;10:19–28.PubMedCrossRefGoogle Scholar
  54. 54.
    Ginsberg ML, Quirt C, Ginsberg AD, et al. Psychiatric illnesses and psychosocial concerns of patients with newly diagnosed lung cancer. Can Med Assoc J 1995;152:1961–1963.Google Scholar
  55. 55.
    Hopwood PS. Depression in patients with lung cancer: prevalence and risk factors. J Clin Oncol 2000;18:893–903.PubMedGoogle Scholar
  56. 56.
    Hughes JE. Depressive illness and lung cancer. II. Follow-up of inoperable patients. Eur J Surg Oncol 1985;11:21–24.PubMedGoogle Scholar
  57. 57.
    Kurtz ME, Kurtz JC, Stommel M, et al. Predictors of depressive symptomatology of geriatric patients with lung cancer: a longitudinal analysis. Psycho-Oncology 2002;11:12–22.PubMedCrossRefGoogle Scholar
  58. 58.
    Buccheri G. Depressive reactions to lung cancer are common and often followed by poor outcome. Eur Respir J 1998;11:173–178.PubMedCrossRefGoogle Scholar
  59. 59.
    Schofield P, Ball D, Smith JG, et al. Optimism and survival in lung carcinoma patients. Cancer (Phila) 2004;100:1276–1282.PubMedCrossRefGoogle Scholar
  60. 60.
    Uchitomi Y, Mikami I, Kugaya A, et al. Physician support and patient psychologic responses after surgery for non-small cell lung carcinoma: a prospective observational study. Cancer (Phila) 2001;92:1926–1935.PubMedCrossRefGoogle Scholar
  61. 61.
    Dowie J, Wildman M. Choosing the surgical mortality threshold for high risk patients with stage Ia non-small cell lung cancer: insights from decision analysis. Thorax 2002;57:7–10.PubMedCrossRefGoogle Scholar
  62. 62.
    Treasure T. Whose lung is it anyway? Thorax 2002;57:3–4.PubMedCrossRefGoogle Scholar
  63. 63.
    Auperin A, Arriagada R, Pignon JP, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic cranial irradiation overview collaborative group. N Engl J Med 1999;12:476–484.CrossRefGoogle Scholar
  64. 64.
    Turrisi AT, Sherman CA. The treatment of limited small cell lung cancer: a report of the progress made and future prospects. Eur J Cancer 2002;38:279–291.PubMedCrossRefGoogle Scholar
  65. 65.
    Johnson BE, Becker B, Goff WB, et al. Neurologic, neuropsychologic, computed cranial tomography scan abnormalities in 2-to 10-year survivors of small-cell lung cancer. J Clin Oncol 1985;3:1659–1667.PubMedGoogle Scholar
  66. 66.
    Albain KS, Crowley JJ, Livingston RB. Long-term survival and toxicity in small cell lung cancer. Chest 1991;99:1425–1432.PubMedGoogle Scholar
  67. 67.
    van Oosterhout AGM, Ganzevles PGJ, Wilmink JT, et al. Sequelae in long-term survivors of small cell lung cancer. Int J Radiat Oncol Biol Phys 1996;34:1037–1044.PubMedCrossRefGoogle Scholar
  68. 68.
    Akechi T, Akizuke N, Sakuma K, et al. Somatic symptoms for diagnosing major depression in cancer patients. Psychosomatics 2003;44:244–248.PubMedCrossRefGoogle Scholar
  69. 69.
    Sarna L. Women with lung cancer: impact on quality of life. Qual Life Res 1993;2:13–22.PubMedCrossRefGoogle Scholar
  70. 70.
    Billante CR, Specto B, Hudson M, et al. Voice outcome following thyroplasty in patients with cancer-related vocal fold paralysis. Auris Nasus Larnyx 2001;28:315–321.CrossRefGoogle Scholar
  71. 71.
    Nou E, Aberg T. Quality of survival in patients with surgically treated bronchial carcinoma. Thorax 1980;35:255–263.PubMedGoogle Scholar
  72. 72.
    Lassen U, Osterlind K, Hansen M, et al. Long-term survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years. An analysis of 1,714 consecutive patients. J Clin Oncol 1995;13:1215–1220.PubMedGoogle Scholar
  73. 73.
    Shelby RA, Taylor KL, Kerner JF, et al. The role of community-based and philanthropic organizations in meeting cancer patient and caregiver needs. CA Cancer J Clin 2002;52:229–246.PubMedGoogle Scholar
  74. 74.
    Pukrop R, Rehse B. Effects of psychosocial interventions on quality of life in adult cancer patients: meta analysis of 37 published controlled outcome studies. Patient Educ Counsel 2003;50:179–186.Google Scholar
  75. 75.
    Johnson BE. Second lung cancers in patients after treatment for an initial lung cancer. JNCI 1998;90:1335–1345.PubMedCrossRefGoogle Scholar
  76. 76.
    Johnson-Early A, Cohen MH, Minna JD, et al. Smoking abstinence and small cell lung cancer survival: an association. JAMA 1980;244:2175–2179.CrossRefGoogle Scholar
  77. 77.
    Kawahara M, Ushijima S, Kamimori T, et al. Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: the role of smoking cessation. Br J Cancer 1998;78:409–412.PubMedGoogle Scholar
  78. 78.
    Richardson GE, Tucker MA, Venzon DJ. Smoking cessation after successful treatment of small-cell lung cancer is associated with fewer smoking-related second primary cancers. Ann Intern Med 1993;119:383–390.PubMedGoogle Scholar
  79. 79.
    Gritz E, Vidrine DJ, Lazev AB. Smoking cessation in cancer patients: never too late to quit. In: Given B, Given CW, Champion V, et al. (eds). Evidence-Based Interventions in Oncology. New York: Springer, 2004.Google Scholar
  80. 80.
    Videtic GMM, Stitt LW, Dar R, et al. Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. J Clin Oncol 2003;21:1544–1549.PubMedCrossRefGoogle Scholar
  81. 81.
    Anthonisen N, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA 1994;272:1497–1505.PubMedCrossRefGoogle Scholar
  82. 82.
    Peto R, Darby S, Deo H, et al. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case control studies. BMJ 2000;321:323–329.PubMedCrossRefGoogle Scholar
  83. 83.
    Doll R, Peto R, Boreham J, et al. Mortality in relation to smoking: 50 years’ observation on male British doctors. BMJ 2004. doi: 10.1136/bmj.38142.554479.AE, retrieved July 15, 2004.Google Scholar
  84. 84.
    Mokdad AH, Marks JS, Stroup DF, et al. Actual causes of death in the United States, 2000. JAMA 2004;291:1238–1245.PubMedCrossRefGoogle Scholar
  85. 85.
    American Society of Clinical Oncology. American Society of Clinical Oncology Policy Statement Update: Tobacco control—reducing cancer incidence and saving lives. J Clin Oncol 2003;21:2777–2786.CrossRefGoogle Scholar
  86. 86.
    Fujisawa T, Iizasa T, Saitoh Y, et al. Smoking before surgery predicts poor long-term survival in patients with stage I non-small cell lung carcinomas. J Clin Oncol 1999;17:2086–2091.PubMedGoogle Scholar
  87. 87.
    Clarke MM, Cox LS, Jett JR, et al. Effectiveness of smoking cessation self-help materials in a lung cancer screening population. Lung Cancer 2004;44:13–21.CrossRefGoogle Scholar
  88. 88.
    Cox L, Africano N, Tercyak K, et al. Nicotine dependence treatment for patients with cancer: review and recommendations. Cancer (Phila) 2003;98:632–644.PubMedCrossRefGoogle Scholar
  89. 89.
    Cox LS, Sloan JA, Patten CA, et al. Smoking behavior of 226 patients with diagnosis of stage IIIA/IIIB non-small cell lung cancer. Psycho-Oncology 2002;11:472–478.CrossRefGoogle Scholar
  90. 90.
    Davison G, Duffy M. Smoking habits of long-term survivors of surgery for lung cancer. Thorax 1982;37:331–333.PubMedGoogle Scholar
  91. 91.
    Gritz ER, Nisenbaum R, Elashoff RE, et al. Smoking behavior following diagnosis in patients with stage I non-small cell lung cancer. Cancer Causes Control 1991;2:105–112.PubMedCrossRefGoogle Scholar
  92. 92.
    Sridhar KS, Raub WA Jr. Present and past smoking history and other predisposing factors in 100 lung cancer patients. Chest 1992;101:19–25.PubMedGoogle Scholar
  93. 93.
    Dresler CM, Bailey M, Roper CR, et al. Smoking cessation and lung cancer resection. Chest 1996;110:1199–1202.PubMedGoogle Scholar
  94. 94.
    Grannis FW. The lung cancer and cigarette smoking web page: a pilot study in telehealth promotion on the World Wide Web. Can Respir J 2001;8:333–337.PubMedGoogle Scholar
  95. 95.
    Browning KK, Ahijevych KA, Ross P, et al. Implementing the Agency for Health Care Policy and Research’s Smoking Cessation Guideline in a Lung Cancer Surgery Clinic. Oncol Nurs Forum 2000;27:1248–1254.PubMedGoogle Scholar
  96. 96.
    Wewers ME, Jenkins L, Mignery T. A nurse-managed smoking cessation during diagnostic testing for lung cancer. Oncol Nurs Forum 1997;24:1419–1422.PubMedGoogle Scholar
  97. 97.
    Ebbert JO, Yang P, Vachon CM, et al. Lung cancer risk reduction after smoking cessation: observations from a prospective cohort of women. J Clin Oncol 2003;21:921–926.PubMedCrossRefGoogle Scholar
  98. 98.
    Chapple A, Ziebland S, McPherson A. Stigma, shame, and blame experienced by patients with lung cancer: a qualitative study. BMJ 2004. doi: 10.1136/bmj.38111.639734.7c (published June 11), retreived July 15, 2004.Google Scholar
  99. 99.
    Marteu T, Riordan DC. Staff attitudes towards patients: the influence of causal attributions for illness. Br J Clin Psychol 1992;31:107–110.Google Scholar
  100. 100.
    Faller H, Schilling S, Lang H. Causal attribution and adaptation among lung cancer patients. J Psychosom Res 1995;39:619–627.PubMedCrossRefGoogle Scholar
  101. 101.
    Brown JK, Byers T, Doyle C, et al. Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA A Cancer J Clin 2003;53:268–291.Google Scholar
  102. 102.
    The Alpha Tocopherol Betacarotene Prevention Study Group. The effect of vitamin E and betacarotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029–1035.CrossRefGoogle Scholar
  103. 103.
    Omenn G, Goodman G, Thornquist M, et al. Effects of a combination of betacarotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150–1155.PubMedCrossRefGoogle Scholar
  104. 104.
    Phase III randomized chemoprevention study of selenium in participants with previously resected stage I non-small cell lung cancer (Protocol ID E-5597)., retreived July 15, 2004.Google Scholar
  105. 105.
    Ludbrook JJ, Truong PT, MacNeil MV, et al. Do age and comorbidity impact treatment allocation and outcomes in limited stage small-cell lung cancer? A community-based population analysis. Int J Radiat Oncol Biol Phys 2003;55:1321–1330.PubMedCrossRefGoogle Scholar
  106. 106.
    Kurz ME, Kurtz JC, Stommel M, et al. Loss of physical functioning among geriatric cancer patients: relationships to cancer site, treatment, comorbidity and age. Eur J Cancer 1997;33:2352–2358.CrossRefGoogle Scholar
  107. 107.
    Kurtz ME, Kurtz JC, Stommel M, et al. Symptomatology and loss of physical functioning among geriatric patients with lung cancer. J Pain Symptom Manag 2000;19:249–256.CrossRefGoogle Scholar
  108. 108.
    Patel JD, Bach PB, Kris MG. Lung cancer in US women: a contemporary epidemic. JAMA 2004;291:1763–1768.PubMedCrossRefGoogle Scholar
  109. 109.
    Henschke CI, Miettinen OS. Women’s susceptibility to tobacco carcinogens. Lung Cancer 2004;43:1–5.PubMedCrossRefGoogle Scholar
  110. 110.
    Thun M, Lally C, Flannery J, et al. Cigarette smoking and changes in histopathology of lung cancer. JNCI 1997;89:1580–1586.PubMedCrossRefGoogle Scholar
  111. 111.
    Lienert T, Serke N, Schofeld N, et al. Lung cancer in young females. Eur Respir J 2000;16:986–990.PubMedCrossRefGoogle Scholar
  112. 112.
    Singh GK, Miller BA, Hankey BF. Changing area socioeconomic patterns in U.S. cancer mortality, 1950-1998. Part II: Lung and colorectal cancers. JNCI 2002;94:916–925.PubMedGoogle Scholar
  113. 113.
    Centers for Disease Control and Prevention. Cigarette smoking among adults: United States, 2002. MMWR 2004;53:427–431.Google Scholar
  114. 114.
    Barbeau EM, Krieger N, Soobader MJ. Working class matters: socioeconomic disadvantage, race/ethnicity, gender, and smoking in NHIS 2000. Am J Public Health 2003;94:269–278.Google Scholar
  115. 115.
    Centers for Disease Control and Prevention. Prevalence of cigarette use among 14 racial/ethnic populations—United States, 1999–2001. MMWR (Morbid Mort Wkly Rep) 2004;53:49–52.Google Scholar
  116. 116.
    Leisktikow B. Lung cancer rates as an index of tobacco smoke exposures: validation against black male-non-lung cancer death rates, 1969–2000. Prev Med 2004;38:511–515.CrossRefGoogle Scholar
  117. 117.
    Bach PB, Cramer LD, Warren JL, et al. Racial differences in the treatment of early-stage lung cancer. N Engl J Med 1999;341:1198–1205.PubMedCrossRefGoogle Scholar
  118. 118.
    Greenwald HP, Polissar NH, Borgatta EF, et al. Social factors, treatment, and survival in early-stage non-small cell lung cancer. Am J Public Health 1998;88:1681–1684.PubMedCrossRefGoogle Scholar
  119. 119.
    Ward E, Jemal A, Cokkinides V, et al. Cancer disparities by race/ ethnicity and socioeconomic status. CA A Cancer J Clin 2004;54:78–93.Google Scholar
  120. 120.
    Montazeri A, Hole DJ, Milroy R, et al. Quality of life in lung cancer patients: does socioeconomic status matter? Health Qual Life Outcomes 2003;1:19–24.PubMedCrossRefGoogle Scholar
  121. 121.
    Lopez-Encuentra A. Bronchogenic Carcinoma Co-Operative Group: comorbidity inoperable lung cancer. A multicenter descriptive study on 2992 patients. Lung Cancer 2002;35:263–269.PubMedCrossRefGoogle Scholar
  122. 122.
    Gritz E. Facilitating smoking cessation in cancer patients. Tobacco Control 2000;i50(suppl 1):50.CrossRefGoogle Scholar
  123. 123.
    U. S. Department of Health and Human Services. The health consequences of tobacco use: a report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2003.Google Scholar
  124. 124.
    Nakayma M, Satoh H, Sekizawa K. Risk of cancers in COPD patients. Chest 2003;123:1775.CrossRefGoogle Scholar
  125. 125.
    Beck GJ, Doyle CA, Schachter EN. Smoking and lung function. Am Rev Respir Dis 1981;123:149–155.PubMedGoogle Scholar
  126. 126.
    Ko CY, Maggard M, Livingston EH. Evaluating health utility in patients with melanoma, breast cancer, colon cancer, and lung cancer. A nationwide, population-based assessment. J Surg Res 2003;114:1–5.PubMedCrossRefGoogle Scholar
  127. 127.
    Henschke CI, McCauley DI, Yankelevitz DF, et al. Early lung cancer action project: overall design and findings from baseline screening. Lancet 1999;354:99–105.PubMedCrossRefGoogle Scholar
  128. 128.
    Patz EF, Swensen SJ, Herndon RE. Estimate of lung cancer mortality from low-dose spiral computed tomography screening trials: implications for current mass screening recommendations. J Clin Oncol 2004;22:2202–2206.PubMedCrossRefGoogle Scholar
  129. 129.
    Shahidi H, Kvale PA. Long-term survival following surgical treatment of solitary brain metastasis in non-small cell lung cancer. Chest 1996;109:271–276.PubMedGoogle Scholar
  130. 130.
    Dow KH. Challenges and opportunities in cancer survivorship research. Oncol Nurs Forum 2003;30:455–469.PubMedGoogle Scholar
  131. 131.
    Schumacher A, Riesenbeck D, Braunheim M, et al. Combined modality treatment for locally advanced non-small cell lung cancer: preoperative chemoradiation does not result in poorer quality of life. Lung Cancer 2004;44:89–97.PubMedCrossRefGoogle Scholar
  132. 132.
    Colice GL, Rubins J, Unger M. Follow-up and surveillance of the lung cancer patient following curative-intent therapy. Chest 2003;123:272S–283S.PubMedCrossRefGoogle Scholar
  133. 133.
    McManus K. Concerns of poor quality of life should not deprive patients of the opportunity for curative surgery. Thorax 2003;58:189.PubMedCrossRefGoogle Scholar
  134. 134.
    Natale RB. Effects of ZD 1839 (Iressa, Gefitinib) treatment on symptoms and quality of life in patients with advanced nonsmall cell lung cancer. Semin Oncol 2004;31:23–30.PubMedCrossRefGoogle Scholar
  135. 135.
    Welcker K, Marian P, Thetter O, et al. Cost and quality of life in thoracic surgery. Thorac Cardiovasc Surg 2003;51:260–266.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Linda Sarna
    • 1
  • Frederic W. GrannisJr.
    • 2
  • Anne Coscarelli
    • 3
    • 4
  1. 1.School of NursingUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Department of Thoracic SurgeryCity of Hope National Medical CenterDuarteUSA
  3. 3.Department of Public HealthUniversity of California-David Geffen School of MedicineLos AngelesUSA
  4. 4.Ted Mann Family Resource CenterUniversity of California-David Geffen School of MedicineLos AngelesUSA

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