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This chapter reviews atmospheric standards with particular attention to pathophysiology and operational issues associated with pressure, temperature, humidity, and trace contaminants. Next follows a discussion of the physiologically relevant atmospheric gases oxygen and carbon dioxide along with their associated clinical conditions (e.g., hypoxia and hypercarbia). The chapter concludes with a review of the environmental control systems found on board past and present spacecraft.

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References

  1. Jones W, Ingelfinger A. Atmospheric control. In: Parker J, West V (eds.), Bioastronautics Data Book. 2nd edn. Washington, DC: National Aeronautics and Space Administration; 1973:807-846. NASA SP-3006.

    Google Scholar 

  2. Malkin V. Barometric pressure and gas composition of spacecraft cabin air. In: Sulzman FM, Genin AM (eds.), Life Support and Habit-ability, Vol. II. Washington, DC: American Institute of Aeronautics and Astronautics; 1993:1-36. Nicogossian A, Mohler S, Gazenko O, Grigoriev AI, series (eds.), Space Biology and Medicine: Joint U.S./ Russian Publication in Five Volumes.

    Google Scholar 

  3. Graf J, Finger B, Daues K. Life Support Systems for the Space Environment: Basic Tenets for Designers, Rev. A, June 27, 2002. Web page available at: http://advlifesupport.jsc.nasa.gov. Accessed October 11, 2002.

  4. International Civil Aviation Organization. Manual of the ICAO Standard Atmosphere. 2nd edn. Montreal: ICAO; 1964.

    Google Scholar 

  5. Billings C. Barometric pressure. In: Parker J, West V (eds.), Bioastronautics Data Book. 2nd edn. Washington, DC: National Aeronautics and Space Administration; 1973:1-34. NASA SP-3006.

    Google Scholar 

  6. Busby D. Space Clinical Medicine, A Prospective Look at Medi-cal Problems From Hazards of Space Operations. Dordrecht, Holland: D. Reidel Publishing Company; 1968.

    Google Scholar 

  7. Harland D. The Mir Space Station: A Precursor to Space Col-onization. Chichester, UK: John Wiley and Sons; 1997.

    Google Scholar 

  8. Waligora J, Powell M, Sauer R. Spacecraft life-support sys-tems. In: Nicogossian AE, Huntoon CL, Pool SL (eds.), Space Physiology and Medicine, 3rd edn. Philadelphia: Lea & Febiger; 1994:109-127.

    Google Scholar 

  9. Ernsting J, Nicholsen A, Rainford D. Aviation Medicine. 3rd edn. Oxford, UK: Butterworth-Heinemann; 1999.

    Google Scholar 

  10. Nicogossian AE, Huntoon CL, Pool SL (eds.), Space Physiology and Medicine. 3rd edn. Philadelphia, PA: Lea & Febiger; 1994.

    Google Scholar 

  11. Hackett PH, Roach RC. High-Altitude Medicine., In: Auerbach PS (ed.), Wilderness Medicine. 3rd edn. St. Louis, MO: Mosby Year Book; 1995:3.

    Google Scholar 

  12. Lataste X. The blood-brain barrier in hypoxia. Int J Sports Med 1992; 13:S45-S47.

    Article  PubMed  Google Scholar 

  13. Neubauer J, Melton J, Edelman N. Modulation of respiration dur-ing brain hypoxia. J Appl Physiol 1990; 68:441-451.

    CAS  PubMed  Google Scholar 

  14. Hammond M, Gale GE, Kapitan K, et al. Pulmonary gas exchange in humans during normobaric hypoxic exercise. J Appl Physiol 1986; 16:1749-1757.

    Google Scholar 

  15. Wagner PD, Gale GE, Moon RE, et al. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol 1986; 61:260-270.

    CAS  PubMed  Google Scholar 

  16. Wood S. Interactions between hypoxia and hypothermia. Annu Rev Physiol 1991; 53:71-85.

    Article  CAS  PubMed  Google Scholar 

  17. Yoneda I, Tomoda M, Tokumaru O, et al. Time of useful con-sciousness determination in aircrew members with reference to prior altitude chamber experience and age. Aviat Space Environ Med 2000; 71:72-76.

    CAS  PubMed  Google Scholar 

  18. Pickard JS. The atmosphere and respiration. In: DeHart RL, Davis JR (eds.), Fundamentals of Aerospace Medicine. 3rd edn. Philadel-phia, PA: Lippincott Williams and Wilkins; 2002; Table 2.7, p. 37.

    Google Scholar 

  19. West JB. Tolerance to severe hypoxia: lessons from Mt. Ever-est. Acta Anaesthesiol Scand Suppl. 1990; 34:18-23.

    Article  Google Scholar 

  20. Sutton J, Reeves J, Wagner P, et al. Operation Everest II: oxy-gen transport during exercise at extreme hypoxia. J Appl Physiol 1988; 64:1309-1321.

    CAS  PubMed  Google Scholar 

  21. Powell F, Huey K, Dwinell M. Central nervous system mecha-nisms of ventilatory acclimatization to hypoxia. Resp Physiol 2000; 121:223-236.

    Article  CAS  Google Scholar 

  22. Lambertsen C. Hypoxia, altitude and acclimatization. In: Mountcastle V (ed.), Medical Physiology, 14th edn. St. Louis, MO: Mosby; 1980.

    Google Scholar 

  23. Hackett P, Rabold M. High-altitude medical problems. In: Tintin-alli J, Ruiz E, Krome R (eds.), Emergency Medicine: A Com-prehensive Study Guide. 4th edn. New York, NY: McGraw-Hill Company; 1996.

    Google Scholar 

  24. Scholz H, Schurek H, Eckardt K, Bauer C. Role of erythropoietin in adaptation to hypoxia. Experientia 1990; 46:1197-1201.

    Article  CAS  PubMed  Google Scholar 

  25. Young AJ, Young PM. Human acclimatization to high terrestrial altitude. In: Pandolf K, Sawka M, Gonzalez R (eds.), Human Performance Physiology and Environmental Medicine at Terrestrial Extremes.  Carmel, IN: Cooper Publishing Group; 1988.

    Google Scholar 

  26. Hochachka P. Mechanism and evolution of hypoxia-tolerance in humans. J Exp Biol 1998; 201:1243-1254.

    CAS  PubMed  Google Scholar 

  27. Bebout D, Story D, Roca J, et al. Effects of altitude acclimatiza-tion on pulmonary gas exchange during exercise. J Appl Physiol 1989; 67:2286-2295.

    CAS  PubMed  Google Scholar 

  28. Appenzeller O, Martignoni E. The autonomic nervous system and hypoxia: mountain medicine. J Auton Nerv Syst 1996; 57:1-12.

    Article  CAS  PubMed  Google Scholar 

  29. Conkin J. The Mars Project: Avoiding Decompression Sickness on a Distant Planet. Houston, TX: NASA, Lyndon B. Johnson Space Center; 2000. NASA TM 2000-210188.

    Google Scholar 

  30. Waligora JM, Horrigan DJ, Nicogossian A. The physiology of spacecraft and space suit atmosphere selection. Acta Astronau-tica 1991; 23:171-177.

    Article  CAS  Google Scholar 

  31. Fenton L, Beck G, Djali S, Robinson M. Hypothermia induced by hyperbaric oxygen is not blocked by serotonin antagonists. Pharmacol Biochem Behav 1993; 44:357-364.

    Article  CAS  PubMed  Google Scholar 

  32. Robertson W, Hargreaves J, Herlocher J, et al. Physiologic response to increased oxygen partial pressure II: respiratory stud-ies. Aerospace Med 1964; 35:618-622.

    CAS  PubMed  Google Scholar 

  33. Clark J. Therapeutic and toxic effects of hyperbaric oxygenation. In: Crystal R, West J, et al. (eds.), The Lung: Scientific Founda-tion. New York: Raven Press Ltd.; 1991:2123-2131.

    Google Scholar 

  34. Montgomery AB, Luce JM, Murray JF. Retrosternal pain is an early indicator of oxygen toxicity. Am Rev Respir Dis 1989; 139:1548-50.

    CAS  PubMed  Google Scholar 

  35. Caldwell PR, Lee WL Jr, Schildkraut HS, et al. Changes in lung volume, diffusing capacity, and blood gases in men breathing oxygen. J Appl Physiol 1966; 21:1477-83.

    CAS  PubMed  Google Scholar 

  36. Nakae H, Tanaka H, Inaba H. Failure to clear casts and secretions following inhalation injury can be dangerous: report of a case. Burns 2001; 27:189-91.

    Article  CAS  PubMed  Google Scholar 

  37. Robinson L, Miller RH. Smoke inhalation injuries. Am J Otolar-yngol 1986; 7:375-80.

    Article  CAS  Google Scholar 

  38. Mission Operations Directorate, Space Flight Training Division. International Space Station Familiarization Manual. Houston, TX: National Aeronautics and Space Administration; 1998. NASA TD 9702A.

    Google Scholar 

  39. Eckart P. Spaceflight Life Support and Biospherics. Torrance, CA: Microcosm Press; 1996.

    Google Scholar 

  40. Rahn H, Fenn WO. The Oxygen—Carbon Dioxide Diagram. WADC-TR-53-255, Wright-Patterson Air Force Base, Ohio 1953.

    Google Scholar 

  41. Gelfand R, Lambertsen CJ, Beck G, et al. Dynamic responses of SaO2 and “CBF” to abrupt exposure to inhaled 10% O2/4% CO2 at rest, followed by 50 and 100 watts exercise. Undersea Hyper-baric Med 1995; 22(Supp.):70-71.

    Google Scholar 

  42. Rousseau J. Atmospheric Control Systems for Space Vehicles. Report No. ASD-TDR-62-527, AiResearch Manufacturing Divi-sion, Los Angeles California; March 1963.

    Google Scholar 

  43. Wieland P. Designing for Human Presence in Space: An Introduc-tion to Environmental Control and Life Support Systems. NASA Marshall Space Flight Center, Huntsville, AL. NASA Scientific and Technical Information Program; 1994: Page 25. NASA RP-1324.

    Google Scholar 

  44. Wieland PO. Designing for Human Presence in Space: An Intro-duction to Environmental Control and Life Support Systems. Marshall Space Flight Center, AL: NASA Scientific and Tech-nical Information Program; 1994: Chapter 5. NASA RP-1324.

    Google Scholar 

  45. Churchill SE (ed.), Fundamentals of Space Life Sciences. Malabar, FL: Krieger Publishing Co.; 1997.

    Google Scholar 

  46. Rippstein WJ, Schneider HJ. Toxicological aspects of the Skylab program. In: Johnson RS, Dietlein LF (eds.), Biomedical Results From Skylab. Washington, DC: U.S. Government Printing Office; 1977:70-73. NASA SP-377.

    Google Scholar 

  47. Wieland PO. Designing for Human Presence in Space: An Intro-duction to Environmental Control and Life Support Systems. Mar-shall Space Flight Center, AL: NASA Scientific and Technical Information Program; 1994: Appendix C, C.2. NASA RP-1324.

    Google Scholar 

  48. Wieland PO. Designing for Human Presence in Space: An Intro-duction to Environmental Control and Life Support Systems. Marshall Space Flight Center, AL: NASA Scientific and Techni-cal Information Program; 1994; 2.3. NASA RP-1324.

    Google Scholar 

  49. Link MM. Space Medicine in Project Mercury. Washington, DC: NASA Scientific and Technical Information Division; 1965. NASA SP-4003.

    Google Scholar 

  50. Johnston RS, Dietlein LF, Berry CA (eds.), Biomedical Results of Apollo. Washington, DC: NASA Scientific and Technical Infor-mation Division; 1975. NASA SP-368.

    Google Scholar 

  51. Hacker BC, Grimwood, JM. On the Shoulders of Titans: A His-tory of Project Gemini. Washington, DC: NASA Scientific and Technical Information Division; 1977. NASA SP-4203.

    Google Scholar 

  52. Collins M. Carrying the Fire: an Astronaut’s Journeys. New York, NY: Farrar, Straus, and Giroux, Inc.; 1974.

    Google Scholar 

  53. Ezell, EC, Ezell LN. The Partnership: A History of the Apollo-Soyuz Test Project. Washington DC: NASA Scientific and Tech-nical Information Division; 1978. NASA SP-4209.

    Google Scholar 

  54. West JB. Respiratory Physiology—The Essentials. Baltimore, MD: Williams & Wilkins Company; 1974.

    Google Scholar 

  55. Wieland PO. Living Together in Space: The Design and Opera-tion of the Life Support Systems on the International Space Station. Marshall Space Flight Center, AL: NASA Scientific and Technical Information Program; 1998. NASA/TM-1998-206956.

    Google Scholar 

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Bacal, K., Beck, G., Barratt, M.R. (2008). Hypoxia, Hypercarbia, and Atmospheric Control. In: Barratt, M.R., Pool, S.L. (eds) Principles of Clinical Medicine for Space Flight. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68164-1_22

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  • DOI: https://doi.org/10.1007/978-0-387-68164-1_22

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