A General Model for Linkage Analysis in Controlled Crosses

Part of the Statistics for Biology and Health book series (SBH)

Statistical methods for linkage analysis in a backcross or F2 population derived from two inbred lines were described in the previous chapter. An advantage of linkage analysis using these inbred line crosses is that the parental linkage phase between different genetic loci is known and therefore the patterns of marker segregation can be determined and the linkage measured in terms of the recombination fraction tested. However, this inbred line-based analysis is not appropriate for outcrossing species in which it is not possible to generate homozygous lines through successive inbreeding.


Linkage Analysis Gene Order Dominant Marker Informative Marker Recombination Fraction 
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© Springer Science + Business Media, LLC 2007

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