Linkage is the tendency for genes to be inherited together because they are located near one another on the same chromosome. Linkage analysis of markers lays a foundation for the construction of a genetic linkage map and the subsequent molecular dissection of quantitative traits using the map. Linkage analysis is based on the cosegregation of adjacent markers and their cotransmission to the next progeny generation. The prerequisite of linkage analysis between any two markers is their known allelic arrangements (i.e., linkage phases) on the homologous chromosome so that parental (or nonrecombinant) vs. nonparental (or recombinant) haplotypes can be readily distinguished. In many domesticated plants and animals, phase-known mapping pedigrees can be established using a segregating population, such as the backcross or F2, derived from two homologous inbred lines. (Recall the definitions in Section 1.5.) Theories for linkage analysis in such segregating pedigrees have been well-developed.
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© 2007 Springer Science + Business Media, LLC
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(2007). Linkage Analysis and Map Construction. In: Statistical Genetics of Quantitative Traits. Statistics for Biology and Health. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68154-2_3
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DOI: https://doi.org/10.1007/978-0-387-68154-2_3
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