Interval Mapping with Regression Analysis

Part of the Statistics for Biology and Health book series (SBH)

The genetic analysis of quantitative traits includes two major tasks: (1) identifying the location of QTLs affecting a quantitative trait using a genetic linkage map constructed from molecular markers, and (2) estimating the genetic effects of the QTLs on the phenotype. If the genotypes of a putative QTL were known for all individuals, its genomic location could be readily determined using a marker linkage analysis. Furthermore, the genetic effects of the QTL could be precisely estimated and tested by simple t tests or ANOVA. However, it is not possible for the genotypes of QTLs to be directly observed; instead they should be inferred from observed marker and phenotypic information. As was seen in Chapter 8, a marker analysis cannot unambiguously separate the genetic effects of a QTL from the recombination fraction between the markers and QTL.


Conditional Probability Interval Mapping Marker Genotype Marker Interval Recombination Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2007

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