Skip to main content

Kidney Transplantation

  • Chapter
Book cover Surgery

Abstract

In 2002 in the United States, 431,281 patients received treatment for end-stage renal disease (ESRD), including 308,910 on dialysis and 122,374 with a functioning renal transplant.1 The prevalence of ESRD is increasing at an annual rate of 4%, down from 9% a decade ago. In 2004, there were 15,977 renal transplants performed in the United States, and two-thirds of renal transplant patients are now alive 5 years after transplantation, compared to one-third on either hemodialysis or peritoneal dialysis. The 1-year mortality of renal transplant patients is 6% for deceased donor recipients and 3% for living donor kidney recipients compared to 25% for patients treated with dialysis, reflecting the fact that transplant recipients represent a relatively healthier subset of patients with ESRD compared to dialysis patients.2 Nevertheless, the death rate on dialysis is higher than after transplantation even after adjusting for patient characteristics.3

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. U.S. Renal Data System. USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Available at: www.usrds.org.

    Google Scholar 

  2. HHS/HRSA/SPB/DOT, UNOS, URREA. 2003 OPTN/SRTR Annual Report: Transplant Data 1993–2002. Available at: www.ustransplant.org.

    Google Scholar 

  3. Meier-Kriesche HU, Ojo AO, Port FK, et al. Survival improvement among patients with end-stage renal disease: trends over time for transplant recipients and wait-listed patients. J Am Soc Nephrol 2001;12:1293–1296.

    PubMed  CAS  Google Scholar 

  4. Pastan S, Bailey J. Dialysis therapy. N Engl J Med 1998;338:1428–1437.

    Article  PubMed  CAS  Google Scholar 

  5. Knechtle SJ, Pirsch JD, D’Alessandro AM, et al. Renal transplantation at the University of Wisconsin in the cyclosporine era. In Terasaki PI, Cecka JM, eds. Clinical Transplants 1993. Los Angeles: UCLA Tissue Typing Laboratory; 1994;211–218.

    Google Scholar 

  6. Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal disease. Am J Transplant 2004;4:1662–1668.

    Article  PubMed  Google Scholar 

  7. Laupacis A, Keown P, Pus N, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int 1996;50:235–242.

    Article  PubMed  CAS  Google Scholar 

  8. Krmar RT, Eymann A, Ramirez JA, Ferraris JR. Quality of life after kidney transplantation in children. Transplantation 1997;64:540–541.

    Article  PubMed  CAS  Google Scholar 

  9. Joseph JT, Baines LS, Morris MC, Jindal RM. Quality of life after kidney and pancreas transplantation: a review. Am J Kidney Dis 2003;42:431–445.

    Article  PubMed  Google Scholar 

  10. Karam VH, Gasquet I, Delvart V, et al. Quality of life in adult survivors beyond 10 years after liver, kidney, and heart transplantation. Transplantation 2003;76:1699–1704.

    Article  PubMed  Google Scholar 

  11. Danovitch GM, Hariharan S, Pirsch JD, et al. for the Clinical Practice Guidelines Committee of the American Society of Transplantation. Management of the waiting list for cadaveric kidney transplants: report of a survey and recommendations by the Clinical Practice Guidelines Committee of the American Society of Transplantation. J Am Soc Nephrol 2002;13:528–535.

    PubMed  Google Scholar 

  12. Ramos EL, Tisher CC. Recurrent diseases in the kidney transplant. Am J Kidney Dis 1994;24:142–154.

    PubMed  CAS  Google Scholar 

  13. Hariharan S, Adams MB, Brennan DC, et al. Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR). Transplantation 1999;68:635–641.

    Article  PubMed  CAS  Google Scholar 

  14. Odorico JS, Knechtle SJ, Rayhill SC, et al. The influence of native nephrectomy on the incidence of recurrent disease following renal transplantation for primary glomerulonephritis. Transplantation 1996;61:228–234.

    Article  PubMed  CAS  Google Scholar 

  15. Sayegh MH, Turka LA. The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 1998;338:1813–1821.

    Article  PubMed  CAS  Google Scholar 

  16. Cecka JM. The OPTN/UNOS Renal Transplant Registry 2003. In Cecka JM, Terasaki PI, eds. Clinical Transplants 2003. Los Angeles: UCLA Immunogenetics Center; 2004;1–12.

    Google Scholar 

  17. Kissmeyer-Nielsen F, Olsen S, Petersen VP, Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet 1966;2:662–665.

    Article  PubMed  CAS  Google Scholar 

  18. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969;280:735–739.

    PubMed  CAS  Google Scholar 

  19. Gloor JM, DeGoey S, Ploeger N, et al. Persistence of low levels of alloantibody after desensitization in crossmatch-positive living-donor kidney transplantation. Transplantation 2004;78:221–227.

    Article  PubMed  CAS  Google Scholar 

  20. Stegall MD, Dean PG, Gloor JM. ABO-incompatible kidney transplantation. Transplantation 2004;78:635–640.

    Article  PubMed  Google Scholar 

  21. Van der Werf WJ, D’Alessandro AM, Hoffmann RM, Knechtle SJ. Procurement, preservation, and transport of cadaver kidneys. Surg Clin North Am 1998;78:41–54.

    Article  PubMed  Google Scholar 

  22. Terasaki PI, Cho YW, Cecka JM. Strategy for eliminating the kidney shortage. In Cecka JM, Terasaki PI, eds. Clinical Transplants 1997. Los Angeles: UCLA Tissue Typing Laboratory; 1998;265–267.

    Google Scholar 

  23. D’Alessandro AM, Hoffmann RM, Belzer FO. Non-heart-beating donors: one response to the organ shortage. Transplant Rev 1995;9:168–176.

    Article  Google Scholar 

  24. Chen EP, Bittner HB, Kendall SW, Van Trigt P. Hormonal and hemodynamic changes in a validated animal model of brain death. Crit Care Med 1996;24:1352–1359.

    Article  PubMed  CAS  Google Scholar 

  25. Novitzky D, Wicomb WN, Cooper DKC, et al. Electrocardiographic, hemodynamic and endocrine changes occurring during experimental brain death in the chacma and baboon. J Heart Transplant 1984;4:63–69.

    Google Scholar 

  26. Griepp RB, Stinson EB, Clark DA, et al. The cardiac donor. Surg Gynecol Obstet 1971;133:792–798.

    PubMed  CAS  Google Scholar 

  27. D’Alessandro AM, Hoffmann RM, Knechtle SJ, et al. Successful extrarenal transplantation from non-heart-beating donors. Transplantation 1995;59:977–982.

    Article  PubMed  Google Scholar 

  28. Politano VA, Leadbetter WF. An operative technique for the correction of vesicoureteral reflux. J Urol 1958;79:932–941.

    PubMed  CAS  Google Scholar 

  29. Mangus RS, Haag BW, Carter CB. Stented Lich-Gregoir uretero-neocystostomy: case series report and cost-effectiveness analysis. Transplant Proc 2004;36:2959–2961.

    Article  PubMed  CAS  Google Scholar 

  30. Knechtle SJ. Ureteroneocystostomy for renal transplantation. J Am Coll Surg 1999;188:707–709.

    Article  PubMed  CAS  Google Scholar 

  31. Cecka JM. The UNOS Scientific Renal Transplant Registry—10 years of kidney transplants. In Cecka JM, Terasaki PI, eds. Clinical Transplants 1997. Los Angeles: UCLA Tissue Typing Laboratory; 1998;1–14.

    Google Scholar 

  32. Gruessner RW, Fasola C, Benedetti E, et al. Laparoscopic drainage of lymphoceles after kidney transplantation: indications and limitations. Surgery 1995;117:288–295.

    Article  PubMed  CAS  Google Scholar 

  33. Sankari BR, Geisinger M, Zelch M, et al. Post-transplant renal artery stenosis: impact of therapy on long-term kidney function and blood pressure control. J Urol 1996;155:1860–1864.

    Article  PubMed  CAS  Google Scholar 

  34. D’Alessandro AM, Pirsch JD, Knechtle SJ, et al. Living unrelated renal donation: the University of Wisconsin experience. Surgery 1998;124:604–611.

    Article  PubMed  Google Scholar 

  35. Ross LF, Rubin DT, Siegler M, et al. Ethics of a paired-kidney-exchange program. N Engl J Med 1997;336:1752–1755.

    Article  PubMed  CAS  Google Scholar 

  36. Flowers JL, Jacobs S, Cho E, et al. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg 1997;226:483–490.

    Article  PubMed  CAS  Google Scholar 

  37. Ratner LE, Kavoussi LR, Sroka M, et al. Laparoscopic assisted live donor nephrectomy—a comparison with the open approach. Transplantation 1997;63:229–233.

    Article  PubMed  CAS  Google Scholar 

  38. Horgan S, Benedetti E, Moser F. Robotically assisted donor nephrectomy for kidney transplantation. Am J Surg 2004;188:45S–51S.

    Article  PubMed  Google Scholar 

  39. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: new diagnostic insights and standards. Am J Transplant 2004;4:1562–1566.

    Article  PubMed  Google Scholar 

  40. Pirsch JD, Friedman R. Primary care of the renal transplant patient. J Gen Intern Med 1994;9:29–37.

    Article  PubMed  CAS  Google Scholar 

  41. Mihatsch MJ, Thiel G, Spichtin HP, et al. Morphological findings in kidney transplants after treatment with cyclosporine. Transplant Proc 1983;15:2821.

    Google Scholar 

  42. Nankivell BJ, Borrows RJ, Fung CL, et al. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 2004;78:557–565.

    Article  PubMed  CAS  Google Scholar 

  43. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003;349:2326–2333.

    Article  PubMed  CAS  Google Scholar 

  44. Stoves J, Newstead CG, Baczkowski AJ, et al. A randomized controlled trial of immunosuppression conversion for the treatment of chronic allograft nephropathy. Nephrol Dial Transplant 2004;19:2113–2120.

    Article  PubMed  CAS  Google Scholar 

  45. Bakker RC, Hollander AA, Mallat MJ, et al. Conversion from cyclosporine to azathioprine at three months reduces the incidence of chronic allograft nephropathy. Kidney Int 2003;64:1027–1034.

    Article  PubMed  CAS  Google Scholar 

  46. Miller LW. Cardiovascular toxicities of immunosuppressive agents. Am J Transplant 2002;2:807–818.

    Article  PubMed  CAS  Google Scholar 

  47. Morath C, Mueller M, Goldschmidt H, et al. Malignancy in renal transplantation. J Am Soc Nephrol 2004;15:1582–1588.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Knechtle, S.J. (2008). Kidney Transplantation. In: Norton, J.A., et al. Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68113-9_84

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-68113-9_84

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-30800-5

  • Online ISBN: 978-0-387-68113-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics