Surgery pp 1681-1704 | Cite as

History of Clinical Transplantation

  • Thomas E. Starzl


How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991–1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4


Major Histocompatibility Complex Skin Homograft Kidney Recipient Hyperacute Rejection Human Leukocyte Antigen Match 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Thomas E. Starzl
    • 1
  1. 1.Department of Surgery, Thomas E. Starzl Transplantation InstituteUniversity of PittsburghPittsburghUSA

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