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Surgery pp 1681-1704 | Cite as

History of Clinical Transplantation

  • Thomas E. Starzl

Abstract

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991–1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4

Keywords

Major Histocompatibility Complex Skin Homograft Kidney Recipient Hyperacute Rejection Human Leukocyte Antigen Match 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Terasaki PI, ed. History of HLA: Ten Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1990:1–269.Google Scholar
  2. 2.
    Terasaki PI, ed. History of Transplantation: Thirty–Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1990:1–704.Google Scholar
  3. 3.
    Gibson T, Medawar PB. The fate of skin homografts in man. JAnat 1943;77:299–310.Google Scholar
  4. 4.
    Medawar PB. The behavior and fate of skin autografts and skin homografts in rabbits. J Anat 1944;78:176–199.PubMedGoogle Scholar
  5. 5.
    Billingham RE, Brent L, Medawar PB. “Actively acquired tolerance” of foreign cells. Nature 1953;172:603–606.PubMedCrossRefGoogle Scholar
  6. 6.
    Traub E. Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity, J Exp Med 1936;63:847–861.CrossRefPubMedGoogle Scholar
  7. 7.
    Murphy JB. Transplantability of malignant tumors to the embryos of a foreign species. JAMA 1912;59:874–875.Google Scholar
  8. 8.
    Murphy JB. Factors of resistance to heteroplastic tissuegraftings: studies in tissue specificity. J Exp Med 1914;19:513–522.CrossRefPubMedGoogle Scholar
  9. 9.
    Billingham R, Brent L, Medawar P. Quantitative studies on tissue transplantation immunity: actively acquired tolerance. Philos Trans R Soc Lond B Biol Sci 1956;239:357–412.CrossRefGoogle Scholar
  10. 10.
    Hasek M. Vegetavni hybridisace zivocichu spojenim krevnich obehu v embryonalnim vyvojhi. Cesk Biol 1953;2:265.Google Scholar
  11. 11.
    Owen RD. Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945;102:400–401.PubMedCrossRefGoogle Scholar
  12. 12.
    Anderson D, Billingham RE, Lampkin GH, Medawar PB. The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle. Heredity 1951;5:379–397.CrossRefGoogle Scholar
  13. 13.
    Burnet FM, Fenner F. The Production of Antibodies. 2nd ed. Melbourne: Macmillan; 1949:1–142.Google Scholar
  14. 14.
    Billingham R, Brent L. A simple method for inducing tolerance of skin homografts in mice. Trans Bull 1957;4:67–71.Google Scholar
  15. 15.
    Billingham R, Brent L. Quantitative studies on transplantation immunity: induction of tolerance in newborn mice and studies on the phenomenon of runt disease. Philos Trans R Soc Lond B Biol Sci 1959;242:439–477.CrossRefGoogle Scholar
  16. 16.
    Simonsen M. The impact on the developing embryo and newborn animal of adult homologous cells. APMIS 1957;40:480–500.Google Scholar
  17. 17.
    Brent L. A History of Transplantation Immunology. London: Academic Press; 1997:1–482.CrossRefGoogle Scholar
  18. 18.
    Merrill JP, Murray JE, Harrison JH, Friedman EA, Dealy JB Jr, Dammin GJ. Successful homotransplantation of the kidney between non-identical twins. N Engl J Med 1960;262:1251–1260.CrossRefGoogle Scholar
  19. 19.
    Starzl TE, Groth CG, Brettschneider L, et al. Orthotopic homotransplantation of the human liver. Ann Surg 1968;168:392–415.PubMedCrossRefGoogle Scholar
  20. 20.
    Barnard CN. What we have learned about heart transplants. J Thorac Cardiovasc Surg 1968;56:457–468.PubMedGoogle Scholar
  21. 21.
    Dong E as told by Shumway NE and Lower RR. In: Terasaki PI, ed. History of Transplantation: Thirty–Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1991:435–449.Google Scholar
  22. 22.
    Derom F, Barbier F, Ringoir S, et al. Ten-month survival after lung homotransplantation in man. J Thorac Cardiovasc Surg 1971;61:835–846.PubMedGoogle Scholar
  23. 23.
    Lillehei RC, Simmons RL, Najarian JS, et al. Pancreaticoduodenal allotransplantation: experimental and clinical observations. Ann Surg 1970;172:405–436.PubMedCrossRefGoogle Scholar
  24. 24.
    Goulet O, Revillon Y, Brousse N, et al. Successful small bowel transplantation in an infant. Transplantation (Baltimore) 1992;53:940–943.PubMedCrossRefGoogle Scholar
  25. 25.
    Starzl TE, Rowe M, Todo S, et al. Transplantation of multiple abdominal viscera. JAMA 1989;261:1449–1457.PubMedCrossRefGoogle Scholar
  26. 26.
    Mathe G, Amiel JL, Schwarzenberg L, Cattan A, Schneider M. Haematopoietic chimera in man after allogenic (homologous) bone-marrow transplantation. Br Med J 1963;2:1633–1635.PubMedCrossRefGoogle Scholar
  27. 27.
    Bach FH. Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet 1968;2:1364–1366.PubMedCrossRefGoogle Scholar
  28. 28.
    Gatti RA, Meuwissen HJ, Allen HD, Hong R, Good RA. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 1968;2:1366–1369.PubMedCrossRefGoogle Scholar
  29. 29.
    Thomas ED. Allogeneic marrow grafting: a story of man and dog. In: Terasaki PI, ed. History of Transplantation: Thirty–Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1991:379–393.Google Scholar
  30. 30.
    Starzl TE, Marchioro TL, Waddell WR. The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gynecol Obstet 1963;117:385–395.PubMedGoogle Scholar
  31. 31.
    Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M. Cell migration, chimerism, and graft acceptance. Lancet 1992;339:1579–1582.PubMedCrossRefGoogle Scholar
  32. 32.
    Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993;17:1127–1152.PubMedCrossRefGoogle Scholar
  33. 33.
    Starzl TE, Zinkernagel RM. Antigen localization and migration in immunity and tolerance. N Engl J Med 1998;339:1905–1913.PubMedCrossRefGoogle Scholar
  34. 34.
    Starzl TE, Demetris AJ. Transplantation milestones: viewed with one-and two-way paradigms of tolerance. JAMA 1995;273:876–879.PubMedCrossRefGoogle Scholar
  35. 35.
    Carrel A. The operative technique for vascular anastomoses and transplantation of viscera. Lyon Med 1902;98:859.Google Scholar
  36. 36.
    Woodruff MFA. The Transplantation of Tissues and Organs. Springfield, II: Thomas; 1960:1–777.Google Scholar
  37. 37.
    Simonsen M, Buemann J, Gammeltoft A, et al. Biological incompatibility in kidney transplantation in dogs: experimental and morphological investigations. APMIS 1953;32:36–84.Google Scholar
  38. 38.
    Moore FD, Smith LL, Burnap TK, et al. One-stage homotrans-plantation of the liver following total hepatectomy in dogs. Transplant Bull 1959;6:103–110.PubMedGoogle Scholar
  39. 39.
    Dempster WJ. Kidney homotransplantation. Br J Surg 1953;40:447–465.PubMedCrossRefGoogle Scholar
  40. 40.
    Lillehei RC, Goott B, Miller FB. The physiologic response of the small bowel of the dog to ischemia including prolonged in vitro preservation of the bowel with successful replacement and survival. Ann Surg 1959;150:543–560.PubMedCrossRefGoogle Scholar
  41. 41.
    Moore FD, Wheeler HB, Demissianos HV, et al. Experimental whole organ transplantation of the liver and of the spleen. Ann Surg 1960;152:374–387.PubMedCrossRefGoogle Scholar
  42. 42.
    Starzl TE, Kaupp HA Jr, Brock DR, Lazarus RE, Johnson RV. Reconstructive problems in canine liver homotransplantation with special reference to the postoperative role of hepatic venous flow. Surg Gynecol Obstet 1960;111:733–743.Google Scholar
  43. 43.
    Starzl TE, Kaupp HA Jr. Mass homotransplantation of abdominal organs in dogs. Surg Forum 1960;11:28–30.Google Scholar
  44. 44.
    Lower RR, Shumway NE. Studies on orthotopic homotransplantation of the canine heart. Surg Forum 1960;11:18.PubMedGoogle Scholar
  45. 45.
    Lower RR, Stofer RC, Shumway NE. Homovital transplantation of the heart. J Thorac Cardiovasc Surg 1961;41:196–204.PubMedGoogle Scholar
  46. 46.
    Lower RR, Stofer RC, Hurley EJ, Shumway NE. Complete homograft replacement of the heart and both lungs. Surgery 1961;50:842–845.PubMedGoogle Scholar
  47. 47.
    Jaboulay M. Greffe du reins au pli du coude par soudures arterielles et veineuses [Kidney grafts in the antecubital fossa by arterial and venous anastomosis]. Lyon Med 1906;107:575–577.Google Scholar
  48. 48.
    Unger E. Nierentransplantation [Kidney transplantation]. Wien Klin Wochenschr 1910;47:573–578.Google Scholar
  49. 49.
    Groth CG. Landmarks in clinical renal transplantation. Surg Gynecol Obstet 1972;134:323–328.Google Scholar
  50. 50.
    Reemstsma K, McCracken BH, Schlegel JU, et al. Renal heterotransplantation in man. Ann Surg 1964;160:384–410.Google Scholar
  51. 51.
    Starzl TE, Marchioro TL, Peters GN, et al. Renal heterotransplantation from baboon to man: experience with six cases. Transplantation 1964;2:752–776.PubMedCrossRefGoogle Scholar
  52. 52.
    Voronoy U. Sobre bloqueo del aparato reticuloendotelial del hombre en algunas formas de intoxicacion por el sublimado y sobre la transplantacion del rinon cadaverico como metodo de tratamiento de la anuria consecutiva a aquella intoxicacion [Blocking the reticuloendothelial system in man in some forms of mercuric chloride intoxication and the transplantation of the cadaver kidney as a method of treatment for the anuria resulting from the intoxication]. Siglo Med 1937;97:296–297.Google Scholar
  53. 53.
    Starzl TE. Patterns of permissible donor-recipient tissue transfer in relation to ABO blood groups. In: Experience in Renal Transplantation. Philadelphia: Saunders; 1964:37–47.Google Scholar
  54. 54.
    Ramsey G, Nusbacher J, Starzl TE, Lindsay GD. Isohemagglutinins of grafts origin after ABO-unmatched liver transplantation. N Engl J Med 1984;311:1167–1170.PubMedGoogle Scholar
  55. 55.
    Hamilton DNH, Reid WA. U Voronoy and the first human kidney allograft. Surg Gynecol Obstet 1984;159:289–294.PubMedGoogle Scholar
  56. 56.
    Kuss R, Teinturier J, Milliez P. Quelques essais de greffe rein chez l’homme. Mem Acad Chir 1951;77:755–764.PubMedGoogle Scholar
  57. 57.
    Dubost C, Oeconomos N, Nenna A, Milliez P. Resultats d’une tentative de greffe renale. Bull Soc Med Hop Paris 1951;67:1372–1382.Google Scholar
  58. 58.
    Servelle M, Soulie P, Rougeulle J. Greffe d’une rein de supplicie a une malade avec rein unique congenital, atteinte de nephrite chronique hypertensive azatemique. Bull Soc Med Hop Paris 1951;67:99–104.PubMedGoogle Scholar
  59. 59.
    Michon L, Hamburger J, Oeconomos N, et al. Une tentative de transplantation renale chez l’homme: aspects medicaux et biologiques. Presse Med 1953;61:1419–1423.PubMedGoogle Scholar
  60. 60.
    Merrill JP, Murray JE, Harrison JH, Guild WR. Successful homotransplantation of the human kidney between identical twins. JAMA 1956;160:277–282.Google Scholar
  61. 61.
    Hume DM, Merrill JP, Miller BF, Thorn GW. Experiences with renal homotransplantation in the human: report of nine cases. J Clin Invest 1955;34:327–382.PubMedCrossRefGoogle Scholar
  62. 62.
    Moore FD. The development of tissue transplantation. In: Give and Take. Philadelphia: Saunders; 1964:1–182.Google Scholar
  63. 63.
    Billingham RE, Krohn PL, Medawar PB. Effect of cortisone on survival of skin homografts in rabbits. Br Med J 1951;1:1157–1163.PubMedCrossRefGoogle Scholar
  64. 64.
    Morgan JA. The influence of cortisone on the survival of homografts of skin in the rabbit. Surgery (St. Louis) 1951;30:506–515.PubMedGoogle Scholar
  65. 65.
    Cannon JA, Longmire WP. Studies of successful skin homografts in the chicken. Ann Surg 1952;135:60–68.PubMedCrossRefGoogle Scholar
  66. 66.
    Krohn PL. Effect of cortisone on second set skin homografts in rabbits. Br J Exp Pathol 1954;35:539.PubMedGoogle Scholar
  67. 67.
    Lawler RH, West JW, McNulty PH, Clancy EJ, Murphy RP. Homotransplantation of the kidney in the human. JAMA 1950;144:844–845.Google Scholar
  68. 68.
    Murray G, Holden R. Transplantation of kidneys, experimentally and in human cases. Am J Surg 1954;87:508–519.PubMedCrossRefGoogle Scholar
  69. 69.
    Murray JE, Merrill JP, Harrison JH. Renal homotransplantation in identical twins. Surg Forum 1955;6:432–436.Google Scholar
  70. 70.
    Brown JB. Homografting of skin: with report of success in identical twins. Surgery 1937;1:558–563.Google Scholar
  71. 71.
    Nossal GJV. Antibody production of single cells. Nature 1958;181:1419–1420.PubMedCrossRefGoogle Scholar
  72. 72.
    Dempster WJ, Lennox B, Boag JW. Prolongation of survival of skin homo transplants in the rabbit by irradiation of the host. Br J Exp Pathol 1950;31:670–679.PubMedGoogle Scholar
  73. 73.
    Cannon JA, Terasaki P, Longmire WP. Studies of factors influencing induced tolerance to skin homografts in the chicken. Ann Surg 1957;146:278–284.PubMedGoogle Scholar
  74. 74.
    Main JM, Prehn RT. Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst 1955;15:1023–1029.PubMedGoogle Scholar
  75. 75.
    Trentin JJ. Mortality and skin transplantibility in X-irradiated mice receiving isologous or heterologous bone marrow. Proc Soc Exp Biol Med 1956;92:688–693.PubMedGoogle Scholar
  76. 76.
    Mannick JA, Lochte HL, Ashley CA, Thomas ED, Ferrebee JW. A functioning kidney homotransplant in the dog. Surgery 1959;46:821–828.PubMedGoogle Scholar
  77. 77.
    Storb R, Epstein RB, Bryant J, Ragde H, Thomas ED. Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing. Transplantation 1968;6:587–593.PubMedGoogle Scholar
  78. 78.
    Epstein RB, Storb R, Ragde H, Thomas ED. Cytotoxic typing antisera for marrow grafting in litter mate dogs. Transplantation 1968;6:45–58.PubMedCrossRefGoogle Scholar
  79. 79.
    Hume DM, Jackson BT, Zukoski CF, Lee HM, Kauffman HM, Egdahl RH. The homotransplantation of kidneys and of fetal liver and spleen after total body irradiation. Ann Surg 1960;152:354–373.PubMedCrossRefGoogle Scholar
  80. 80.
    Rapaport FT, Bachvaroff RJ, Mollen N, Hirasawa H, Asano T, Ferrebee JW. Induction of unresponsiveness to major transplantable organs in adult mammals. Ann Surg 1979;190:461–473.PubMedCrossRefGoogle Scholar
  81. 81.
    van Bekkum DW. Bone marrow transplantation: a story of stem cells. In: Terasaki PI, ed. History of Transplantation: Thirty-Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1991:395–434.Google Scholar
  82. 82.
    Murray JE, Merrill JP, Dammin GJ, et al. Study of transplantation immunity after total body irradiation: clinical and experimental investigation. Surgery 1960;48:272–284.PubMedCrossRefGoogle Scholar
  83. 83.
    Murray JE, Merrill JP, Dammin GJ, Dealy JB Jr, Alexandre GW, Harrison JH. Kidney transplantation in modified recipients. Ann Surg 1962;156:337–355.PubMedCrossRefGoogle Scholar
  84. 84.
    Hamburger J, Vaysse J, Crosnier J, et al. Transplantation of a kidney between nonmonozygotic twins after irradiation of the receiver: good function at the fourth month. Presse Med 1959;67:1771–1775.Google Scholar
  85. 85.
    Hamburger J, Vaysse J, Crosnier J, Auvert J, Lalanne CL, Hopper J Jr. Renal homotransplantation in man after radiation of the recipient. Am J Med 1962;32:854–871.PubMedCrossRefGoogle Scholar
  86. 86.
    Kuss R, Legrain M, Mathe G, Nedey R, Carney M. Homologous human kidney transplantation: experience with six patients. Postgrad Med J 1962;38:528–531.PubMedCrossRefGoogle Scholar
  87. 87.
    Kuss R. Human renal transplantation memories, 1951 to 1981. In: Terasaki PI, ed. History of Transplantation: Thirty-Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1991.Google Scholar
  88. 88.
    Murray JE. Nobel Prize lecture: the first successful organ transplants in man. In: Terasaki PI, ed. History of Transplantation: Thirty-Five Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1991:121–143.Google Scholar
  89. 89.
    Goodwin WE, Kaufman JJ, Mims MM, et al. Human renal transplantation: clinical experience with six cases of renal homotransplantation. J Urology 1963;89:13–24.Google Scholar
  90. 90.
    Schwartz R, Dameshek W. Drug-induced immunological tolerance. Nature 1959;183:1682–1683.PubMedCrossRefGoogle Scholar
  91. 91.
    Schwartz R, Dameshek W. The effects of 6-mercaptopurine on homograft reactions. J Clin Invest 1960;39:952–958.PubMedCrossRefGoogle Scholar
  92. 92.
    Meeker W, Condie R, Weiner D, Varco RL, Good RA. Prolongation of skin homograft survival in rabbits by 6-mercaptopurine. Proc Soc Exp Biol Med 1959;102:459–461.Google Scholar
  93. 93.
    Calne RY. The rejection of renal homografts: inhibition in dogs by 6-mercaptopurine. Lancet 1960;1:417–418.PubMedCrossRefGoogle Scholar
  94. 94.
    Zukoski CF, Lee HM, Hume DM. The prolongation of functional survival of canine renal homografts by 6-mercaptopurine. Surg Forum 1960;11:470–472.PubMedGoogle Scholar
  95. 95.
    Calne RY. Inhibition of the rejection of renal homografts in dogs by purine analogues. Transplant Bull 1961;28:445–461.Google Scholar
  96. 96.
    Calne RY, Murray JE. Inhibition of the rejection of renal homo-grafts in dogs by Burroughs Wellcome 57–222. Surg Forum 1961;12:118–120.PubMedGoogle Scholar
  97. 97.
    Calne RY, Alexandre GPJ, Murray JE. A study of the effects of drugs in prolonging survival of homologous renal transplants in dogs. Ann N Y Acad Sci 1962;99:743–761.PubMedCrossRefGoogle Scholar
  98. 98.
    Hitchings GH, Elion GB. The chemistry and biochemistry of purine analogs. Ann N Y Acad Sci 1954;60:195.PubMedCrossRefGoogle Scholar
  99. 99.
    Pierce JC, Varco RL. Induction of tolerance to a canine renal homotransplant with 6-mercaptopurine. Lancet 1962;I:781–782.CrossRefGoogle Scholar
  100. 100.
    Zukoski CF, Callaway JM. Adult tolerance induced by 6-methyl mercaptopurine to canine renal homografts. Nature 1963;198:706–707.PubMedCrossRefGoogle Scholar
  101. 101.
    Starzl TE. Host-graft adaptation. In: Experience in Renal Transplantation. Philadelphia: Saunders; 1964:164–170.Google Scholar
  102. 102.
    Murray JE, Sheil AGR, Moseley R, Knoght PR, McGavic JD, Dammin GJ. Analysis of mechanism of immunosuppressive drugs in renal homotransplantation. Ann Surg 1964;160:449–473.PubMedCrossRefGoogle Scholar
  103. 103.
    Hopewell J, Calne RY, Beswick I. Three clinical cases of renal transplantation. Br Med J 1964;1:411–413.PubMedCrossRefGoogle Scholar
  104. 104.
    Alexandre GPJ, Murray JE. Further studies of renal homotransplantation in dogs treated by combined Imuran therapy. Surg Forum 1962;13:64–66.PubMedGoogle Scholar
  105. 105.
    Murray JE, Merrill JP, Harrison JH, Wilson RE, Dammin GJ. Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N Engl J Med 1963;268:1315–1323.PubMedCrossRefGoogle Scholar
  106. 106.
    Starzl TE, Demetris AJ, Murase N, Trucco M, Thomson AW, Rao AS. The lost chord: microchimerism. Immunol Today 1996;17:577–584.PubMedCrossRefGoogle Scholar
  107. 107.
    Hume DM, Magee JH, Kauffman HM Jr, Rittenbury MS, Prout GR Jr. Renal homotransplantation in man in modified recipients. Ann Surg 1963;158:608–644.PubMedCrossRefGoogle Scholar
  108. 108.
    Woodruff MFA, Robson JS, Nolan B, Lambie AT, Wilson TI, Clark JG. Homotransplantation of kidney in patients treated by preoperative local radiation and postoperative administration of an antimetabolite (Imuran). Lancet 1963:2:675–682.PubMedCrossRefGoogle Scholar
  109. 109.
    Medawar PB. Transplantation of tissues and organs: introduction. Br Med Bull 1965;21:97–99.Google Scholar
  110. 110.
    Woodruff MFA, Woodruff HG. The transplantation of normal tissues: with special reference to auto-and homotransplants of thyroid and spleen in the anterior chamber of the eye, and subcutaneously, in guinea pigs. Phil Trans B 1950;234:559–581.CrossRefGoogle Scholar
  111. 111.
    Woodruff MFA. Evidence of adaptation in homografts of normal tissue. In: Medawar PB, ed. Biological Problems of Grafting. Oxford: Blackwell Scientific; 1959:83–94.Google Scholar
  112. 112.
    Starzl TE. Precepts of renal homotransplantation applied to homografting of other organs. In: Experience in Renal Transplantation. Philadelphia: Saunders; 1964:360–362.Google Scholar
  113. 113.
    Starzl TE, Kaupp HA Jr, Brock DR, Butz GW Jr, Linman JW. Homotransplantation of multiple visceral organs. Am J Surg 1962;103:219–229.PubMedCrossRefGoogle Scholar
  114. 114.
    Murase N, Demetris AJ, Kim DG, Todo S, Fung JJ, Starzl TE. Rejection of the multivisceral allografts in rats: a sequential analysis with comparison to isolated orthotopic small bowel and liver grafts. Surgery 1990;108:880–889.PubMedGoogle Scholar
  115. 115.
    Murase N, Demetris AJ, Matsuzaki T, et al. Long survival in rats after multivisceral versus isolated small bowel allotransplantation under FK 506. Surgery 1991;110:87–98.PubMedGoogle Scholar
  116. 116.
    Starzl TE, Marchioro TL, Porter KA, et al. Factors determining short-and long-term survival after orthotopic liver homotransplantation in the dog. Surgery 1965;58:131–155.PubMedGoogle Scholar
  117. 117.
    Starzl TE. Efforts to mitigate or prevent rejection. In: Experience in Hepatic Transplantation. Philadelphia: Saunders; 1969:203–206.Google Scholar
  118. 118.
    Cordier G, Gamier H, Clot JP, et al. La greffe de foie orthotopique chez le pore. Mem Acad Chir (Paris) 1966;92:799–807.PubMedGoogle Scholar
  119. 119.
    Peacock JH, Terblanche J. Orthotopic homotransplantation of the liver in the pig. In: Read AE, ed. The Liver. London: Butterworth; 1967:333.Google Scholar
  120. 120.
    Calne RY, White HJO, Yoffa DE, et al. Observations of orthotopic liver transplantation in the pig. Br Med J 1967;2:478–480.PubMedCrossRefGoogle Scholar
  121. 121.
    Calne RY, White HJO, Yoffa DE, et al. Prolonged survival of liver transplants in the pig. Br Med J 1967;4:645–648.PubMedCrossRefGoogle Scholar
  122. 122.
    Starzl TE. Rejection in unmodified animals. In: Experience in Hepatic Transplantation. Philadelphia: Saunders; 1969:184.Google Scholar
  123. 123.
    Hunt AC. Pathology of liver transplantation in the pig. In: Read AE, ed. The Liver. London: Butterworth; 1967:337.Google Scholar
  124. 124.
    Porter KA. Pathology of the orthotopic homograft and heterograft. In: Starzl TE, ed. Experience in Hepatic Transplantation. Philadelphia: Saunders; 1969:427.Google Scholar
  125. 125.
    Calne RY, Sells RA, Pena Jr, et al. Induction of immunological tolerance by porcine liver allografts. Nature 1969;223:472–474.PubMedCrossRefGoogle Scholar
  126. 126.
    Zimmerman FA, Davies HS, Knoll PP, Gocke JM, Schmidt T. Orthotopic liver allografts in the rat. Transplantation 1984;37:406–410.CrossRefGoogle Scholar
  127. 127.
    Kamada N, Brons G, Davies H. Fully allogeneic liver grafting in rats induces a state of systemic nonreactivity to donor transplantation antigens. Transplantation 1980;29:429–431.PubMedCrossRefGoogle Scholar
  128. 128.
    Kamada N, Davies HS, Roser B. Reversal of transplantation immunity by liver grafting. Nature 1981;292:840–842.PubMedCrossRefGoogle Scholar
  129. 129.
    Corry RJ, Winn HJ, Russell PS. Primary vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973;16:343–350.PubMedCrossRefGoogle Scholar
  130. 130.
    Russell PS, Chase CM, Colvin RB, Plate JMD. Kidney transplants in mice: an analysis of the immune status of mice bearing long-term H-2 incompatible transplants. J Exp Med 1978;147:1449–1468.PubMedCrossRefGoogle Scholar
  131. 131.
    Starzl TE. Host graft adaptation. In: Experience in Renal Transplantation. Philadelphia: Saunders; 1964:168–170.Google Scholar
  132. 132.
    Starzl TE. Efforts to mitigate or prevent rejection. In: Experience in Hepatic Transplantation. Philadelphia: Saunders; 1969:228–233.Google Scholar
  133. 133.
    Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice: morphology, quantitation, tissue distribution. J Exp Med 1973;137:1142–1162.PubMedCrossRefGoogle Scholar
  134. 134.
    Simonsen M. On the acquisition of tolerance by adult cells. Ann N Y Acad Sci 1960;87:382–390.PubMedCrossRefGoogle Scholar
  135. 135.
    Burnet FM. The Clonal Selection Theory of Acquired Immunity. Nashville: Vanderbilt University Press; 1959:59.Google Scholar
  136. 136.
    Talmage DW. Immunological specificity. Science 1959;129:1649–1653.CrossRefGoogle Scholar
  137. 137.
    Burnet FM. The new approach to immunology. N Engl J Med 1961;264:24–34.PubMedCrossRefGoogle Scholar
  138. 138.
    Miller JFAP. Immunological function of the thymus. Lancet 1961;2:748–749.PubMedCrossRefGoogle Scholar
  139. 139.
    Miller JFAP. Effect of neonatal thymectomy on the immunological responsiveness of the mouse. Proc R Soc Lond Biol Sci 1962;156:415.CrossRefGoogle Scholar
  140. 140.
    Starzl TE, Marchioro TL, Talmage DW, Waddell WR. Splenectomy and thymectomy in human renal homotransplantation. Proc Soc Exp Biol Med 1963;113:929–932.PubMedGoogle Scholar
  141. 141.
    Starzl TE, Porter KA, Andres G, et al. Thymectomy and renal homotransplantation. Clin Exp Immunol 1970;6:803–814.PubMedGoogle Scholar
  142. 142.
    McGregor DD, Gowans JL. Antibody response of rats depleted of lymphocytes by chronic drainage from the thoracic duct. J Exp Med 1963;117:303–320.CrossRefPubMedGoogle Scholar
  143. 143.
    McGregor DD, Gowans JL. Survival of homografts of skin in rats depleted of lymphocytes by chronic drainage from the thoracic duct. Lancet 1964;1:629–632.PubMedCrossRefGoogle Scholar
  144. 144.
    Algire GH, Weaver JM, Prehn RT. Studies on tissue homotransplantation in mice using diffusion chamber methods. Ann N Y Acad Sci 1957;64:1009.PubMedCrossRefGoogle Scholar
  145. 145.
    Starzl TE, Kaupp HA Jr, Brock DR, Linman JW. Studies on the rejection of the transplanted homologous dog liver. Surg Gynecol Obstet 1961;112:135–144.PubMedGoogle Scholar
  146. 146.
    Starzl TE, Butz GW Jr. Surgical physiology of the transplantation of tissues and organs. Surg Clin North Am 1962;42:55–67.PubMedGoogle Scholar
  147. 147.
    Elkinton JR. Moral problems in the use of borrowed organs, artificial and transplanted. Ann Intern Med 1964;60:309–313.Google Scholar
  148. 148.
    Starzl TE, Marchioro TL, Rifkind D, Holmes JH, Rowlands DT Jr, Waddell WR. Factors in successful renal transplantation. Surgery 1964;56:296–318.PubMedGoogle Scholar
  149. 149.
    Rifkind D. Infectious diseases associated with renal transplantation. In: Starzl TE, ed. Experience in Renal Transplantation. Philadelphia: Saunders; 1964:213–238.Google Scholar
  150. 150.
    Starzl TE. Discussion of Murray JE, Wilson RE, Tilney NL, Merrill JP, Cooper WC, Birtch AG, Carpenter CB, Hager EB, Dammin GJ, Harrison H: 5 years experience in renal transplantation with immunosuppressive drugs. Ann Surg 1968;168:416–435.CrossRefGoogle Scholar
  151. 151.
    Perm I, Hammond W, Brettschneider L, Starzl TE. Malignant lymphomas in transplantation patients. Transplant Proc 1969;1:106–112.Google Scholar
  152. 152.
    Starzl TE, Perm I, Putnam CW, Groth CG, Halgrimson CG. Iatrogenic alterations of immunologic surveillance in man and their influence on malignancy. Transplant Rev 1971;7:112–145.PubMedGoogle Scholar
  153. 153.
    Hill RB Jr, Rowlands DT, Rifkind D. Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation. N Engl J Med 1964;271:1021–1027.PubMedCrossRefGoogle Scholar
  154. 154.
    Rifkind D, Starzl TE, Marchioro TL, Waddell WR, Rowlands DT Jr, Hill RB Jr. Transplantation pneumonia. JAMA 1964;189:808–812.PubMedGoogle Scholar
  155. 155.
    Iwasaki Y, Porter KA, Amend JR, Marchioro TL, Zuhlke V, Starzl TE. The preparation and testing of horse antidog and antihuman antilymphoid plasma or serum and its protein fractions. Surg Gynecol Obstet 1967;124:1–24.PubMedGoogle Scholar
  156. 156.
    Starzl TE, Marchioro TL, Porter KA, Iwasaki Y, Cerilli GJ. The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet 1967;124:301–318.PubMedGoogle Scholar
  157. 157.
    Woodruff MFA, Anderson NF. Effect of lymphocyte depletion by thoracic duct fistula and administration of anti-lymphocytic serum on the survival of skin homografts in rats. Nature 1963;200:702.PubMedCrossRefGoogle Scholar
  158. 158.
    Franksson C, Blomstrand R. Drainage of the thoracic lymph duct during homologous kidney transplantation in man. Scand J Urol Nephrol 1967;1:123–131.CrossRefGoogle Scholar
  159. 159.
    Starzl TE, Weil R III, Koep LJ, Iwaki Y, Terasaki PI, Schroter GPJ. Thoracic duct drainage before and after cadaveric kidney transplantation. Surg Gynecol Obstet 1979;149:815–821.PubMedGoogle Scholar
  160. 160.
    Starzl TE, Klintmalm GBG, Iwatsuki S, Schroter G, Weil R III. Late follow-up after thoracic duct drainage in cadaveric renal transplantation. Surg Gynecol Obstet 1981;153:377–382.PubMedGoogle Scholar
  161. 161.
    Slavin S, Reitz B, Bieber CP, Kaplan HS, Strober S. Transplantation tolerance in adult rats using total lymphoid irradiation (TLI): permanent survival of skin, heart, and marrow allografts. J Exp Med 1978;147:700–707.PubMedCrossRefGoogle Scholar
  162. 162.
    Najarian JS, Ferguson RM, Sutherland DER, et al. Fractionated total lymphoid irradiation as preparative immunosuppression in high-risk renal transplantation. Ann Surg 1982;196:442–452.PubMedCrossRefGoogle Scholar
  163. 163.
    Myburgh AJ, Smit AJ, Meyers MA, Botha JR, Browde S, Thomson PD. Total lymphoid irradiation in renal transplantation. World J Surg 1986;10:369–380.PubMedCrossRefGoogle Scholar
  164. 164.
    Metchnikoff I. Etude sur la resorption des cellules. Ann Inst Pasteur 1899;13:737.Google Scholar
  165. 165.
    Inderbitzen T. Histamine in allergic responses of the skin. In: Shafer JH, LeGrippo GA, Chase MW, eds. Henry Ford Hospital International Symposium on Mechanisms of Hypersensitivity. Boston: Little, Brown and Co.; 1959:493–499.Google Scholar
  166. 166.
    Waksman BY, Arbouys S, Arnason BG. The use of specific “lymphocyte” antisera to inhibit hypersensitive reactions of the “delayed” type. J Exp Med 1961;114:997–1022.PubMedCrossRefGoogle Scholar
  167. 167.
    Levey RH, Medawar PB. Nature and mode of action of antilymphocytic antiserum. Proc Natl Acad Sci U S A 1966;56:1130–1137.PubMedCrossRefGoogle Scholar
  168. 168.
    Monaco AP, Wood ML, Russell PS. Adult thymectomy: effect on recovery from immunologic depression in mice. Science 1965;149:432–435.PubMedCrossRefGoogle Scholar
  169. 169.
    Monaco AP, Wood ML, Russell PS. Studies of heterologous anti-lymphocyte serum in mice: immunologic tolerance and chime-rism produced across the H-2 locus with adult thymectomy and antilymphocyte serum. Ann N Y Acad Sci 1966;129:190–209.CrossRefGoogle Scholar
  170. 170.
    Najarian JS, Simmons RL, Gewurz H, Moberg A, Merkel F, Moore GA. Anti-serum to cultured human lymphoblasts: preparation, purification and immunosuppressive properties in man. Ann Surg 1969;170:617–632.PubMedCrossRefGoogle Scholar
  171. 171.
    Kohler G, Milstein C. Continuous culture of fused cells secreting antibody of predefined specificity. Nature 1975;256:495–497.PubMedCrossRefGoogle Scholar
  172. 172.
    Cosimi AB, Colvin RB, Burton RC, et al. Use of monoclonal antibodies to T-cell subsets for immunological monitoring and treatment in recipients of renal allografts. N Engl J Med 1981;305:308–314.PubMedGoogle Scholar
  173. 173.
    Starzl TE, Putnam CW, Halgrimson CG, et al. Cyclophosphamide and whole organ transplantation in human beings. Surg Gynecol Obstet 1971;133:981–991.PubMedGoogle Scholar
  174. 174.
    Starzl TE, Groth CG, Putnam CW, et al. Cyclophosphamide for clinical renal and hepatic transplantation. Transplant Proc 1973;5:511–516.PubMedGoogle Scholar
  175. 175.
    Dreyfuss M, Harri E, Hofmann H, Kobel H, Pache W, Tscherter H. Cyclosporin A and C: new metabolites from Trichoderma polysporum (Link ex Pers) Rifai. Eur J Appl Microbiol 1976;3:125–133.CrossRefGoogle Scholar
  176. 176.
    Ruegger A, Kuhn M, Lichti H, et al. Cyclosporin A, ein immunosuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (Link ex Pers) Rifai. Helv Chim Acta 1976;59:1075–1092.PubMedCrossRefGoogle Scholar
  177. 177.
    Petcher TJ, Weber HP, Ruegger A. Crystal and molecular structure of an iodo-derivative of the cyclic undercepeptide cyclosporin A. Helv Chim Acta 1976;59:1480–1489.PubMedCrossRefGoogle Scholar
  178. 178.
    Borel JF. Comparative study of in vitro and in vivo drug effects on cell-mediated cytoxicity. Immunology 1976;31:631–641.PubMedGoogle Scholar
  179. 179.
    Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1976;6:468–475.PubMedCrossRefGoogle Scholar
  180. 180.
    Borel JF, Feurer C, Magnee C, Stahelin H. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 1977;32:1017–1025.PubMedGoogle Scholar
  181. 181.
    Kostakis AJ, White DJG, Calne RY. Prolongation of rat heart allograft survival by cyclosporin A. Int Res Commun SystMed Sci 1977;5:280.Google Scholar
  182. 182.
    Calne RY, White DJG. Cyclosporin A: a powerful immunosuppressant in dogs with renal allografts. Int Res Commun Syst Med Sci 1977;5:595.Google Scholar
  183. 183.
    Calne RY, White DJG, Rolles K, Smith DP, Herbertson BM. Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A. Lancet 1978;1:1183–1185.PubMedCrossRefGoogle Scholar
  184. 184.
    Calne RY, White DJG, Pentlow BD, et al. Cyclosporin A: preliminary observations in dogs with pancreatic duodenal allografts and patients with cadaveric renal transplants. Transplant Proc 1979;11:860–864.PubMedGoogle Scholar
  185. 185.
    Green CJ, Allison AC. Extensive prolongation of rabbit kidney allograft survival after short-term cyclosporin A treatment. Lancet 1978;1:1182–1183.PubMedCrossRefGoogle Scholar
  186. 186.
    Calne RY, White DJG, Thiru S, et al. Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 1978;2:1323–1327.PubMedCrossRefGoogle Scholar
  187. 187.
    Calne RY, Rolles K, White DJG, et al. Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 1979;2:1033–1036.PubMedCrossRefGoogle Scholar
  188. 188.
    Starzl TE, Weil R III, Iwatsuki S, et al. The use of cyclosporin A and prednisone in cadaver kidney transplantation. Surg Gynecol Obstet 1980;151:17–26.PubMedGoogle Scholar
  189. 189.
    Starzl TE, Klintmalm GBG, Porter KA, Iwatsuki S, Schroter GPJ. Liver transplantation with use of cyclosporin A and prednisone. N Engl J Med 1981;305:266–269.PubMedGoogle Scholar
  190. 190.
    Reitz BA, Wallwork JL, Hunt SA, et al. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med 1982;306:557–564.PubMedGoogle Scholar
  191. 191.
    Griffith BP, Hardesty RL, Deeb GM, Starzl TE, Bahnson HT. Cardiac transplantation with cyclosporin A and prednisone. Ann Surg 1982;196:324–329.PubMedCrossRefGoogle Scholar
  192. 192.
    Cooper J. The evolution of techniques and indications for lung transplantation. Ann Surg 1990;212:249–256.PubMedCrossRefGoogle Scholar
  193. 193.
    Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramanan R, Jain A. FK 506 for human liver, kidney and pancreas transplantation. Lancet 1989;2:1000–1004.PubMedCrossRefGoogle Scholar
  194. 194.
    Kino T, Hatanaka H, Miyata S, et al. FK506, a novel immunosuppressant isolated from Streptomyces: immunosuppressive effect of FK-506 in vitro. Jpn J Antibiot 1987;40:1256–1265.Google Scholar
  195. 195.
    Ochiai T, Nakajima K, Nagata M, et al. Effect of a new immunosuppressive agent, FK506, on heterotopic allotransplantation in the rat. Transplant Proc 1987;19:1284–1286.PubMedGoogle Scholar
  196. 196.
    Murase N, Todo S, Lee P-H, et al. Heterotopic heart transplantation in the rat under FK-506 alone or with cyclosporine. Transplant Proc 1987;19:71–75.PubMedGoogle Scholar
  197. 197.
    Lee P, Murase N, Todo S, Makowka L, Starzl TE. The immunosuppressive effects of FR 900506 in rats receiving heterotopic cardiac allografts. Surg Res Commun 1987;1:325–331.Google Scholar
  198. 198.
    Todo S, Podesta L, ChapChap P, et al. Orthotopic liver transplantation in dogs receiving FK-506. Transplant Proc 1987;19:64–67.PubMedGoogle Scholar
  199. 199.
    Todo S, Ueda Y, Demetris JA, et al. Immunosuppression of canine, monkey, and baboon allografts by FK 506 with special reference to synergism with other drugs, and to tolerance induction. Surgery 1988;104:239–249.PubMedGoogle Scholar
  200. 200.
    Todo S, Demetris A, Ueda Y, et al. Renal transplantation in baboons under FK 506. Surgery 1989;106:444–451.PubMedGoogle Scholar
  201. 201.
    Fung JJ, Todo S, Jain A, et al. Conversion of liver allograft recipients with cyclosporine related complications from cyclosporine to FK 506. Transplant Proc 1990;22:6–12.PubMedGoogle Scholar
  202. 202.
    Armitage JM, Kormos RL, Griffith BP, et al. The clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. Transplant Proc 1991;23:1149–1152.PubMedGoogle Scholar
  203. 203.
    Todo S, Fung JJ, Starzl TE, et al. Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg 1990;212:295–305.PubMedCrossRefGoogle Scholar
  204. 204.
    Starzl TE, Fung J, Jordan M, et al. Kidney transplantation under FK 506. JAMA 1990;264:63–67.PubMedCrossRefGoogle Scholar
  205. 205.
    Starzl TE, Donner A, Eliasziw M, et al. Randomized trialomania? The multicenter liver transplant trials. Lancet 1995;346:1346–1350.PubMedCrossRefGoogle Scholar
  206. 206.
    Fung JJ, Todo S, Tzakis A, et al. Conversion of liver allograft recipients from cyclosporine to FK506-based immunosuppression: benefits and pitfalls. Transplant Proc 1991;23:14–21.PubMedGoogle Scholar
  207. 207.
    Fung JJ, Todo S, Jain A, Demetris AJ, McMichael JP, Starzl TE. The Pittsburgh randomized trial of tacrolimus versus cyclosporine for liver transplantation. J Am Coll Surg 1996;183:117–125.PubMedGoogle Scholar
  208. 208.
    The European FK 506 Multicentre Liver Study Group. Randomized trial comparing tacrolimus (FK 506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994;344:423–428.CrossRefGoogle Scholar
  209. 209.
    The U.S. Multicenter FK 506 Liver Study Group. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994;331:1110–1115.CrossRefGoogle Scholar
  210. 210.
    Starzl TE, Abu-Elmagd K, Tzakis A, Fung JJ, Porter KA, Todo S. Selected topics on FK 506: with special references to rescue of extrahepatic whole organ grafts, transplantation of “forbidden organs,” side effects, mechanisms, and practical pharmacokinetics. Transplant Proc 1991;23:914–919.PubMedGoogle Scholar
  211. 211.
    Todo S, Tzakis AG, Abu-Elmagd K, et al. Intestinal transplantation in composite visceral grafts or alone. Ann Surg 1992;216:223–234.PubMedCrossRefGoogle Scholar
  212. 212.
    Todo S, Tzakis AG, Abu-Elmagd K, et al. Cadaveric small bowel and small bowel-liver transplantation in humans. Transplantation (Baltimore) 1992;53:369–376.PubMedCrossRefGoogle Scholar
  213. 213.
    Starzl TE, Brittain RS, Stonington OG, Coppinger RW, Waddell WR. Renal transplantation in identical twins. Arch Surg 1963;865:600–607.Google Scholar
  214. 214.
    Owens TC, Prevedel AE, Swan H. Prolonged experimental occlusion of thoracic aorta during hypothermia. Arch Surg 1955;70:95–97.Google Scholar
  215. 215.
    Starzl TE. Experience in Renal Transplantation. Philadelphia: Saunders; 1964:68–71.Google Scholar
  216. 216.
    Marchioro TL, Huntley RT, Waddell WR, Starzl TE. Extracorporeal perfusion for obtaining postmortem homografts. Surgery 1963;54:900–911.PubMedGoogle Scholar
  217. 217.
    Ackerman JR, Snell ME. Cadaveric renal transplantation. Br J Urol 1968;40:515–521.CrossRefGoogle Scholar
  218. 218.
    Merkel FK, Jonasson O, Bergan JJ. Procurement of cadaver donor organs: evisceration technique. Transplant Proc 1972;4:585–589.PubMedGoogle Scholar
  219. 219.
    Starzl TE, Hakala TR, Shaw BW Jr, et al. A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet 1984;158:223–230.PubMedGoogle Scholar
  220. 220.
    Starzl TE, Miller C, Broznick B, Makowka L. An improved technique for multiple organ harvesting. Surg Gynecol Obstet 1987;165:343–348.PubMedGoogle Scholar
  221. 221.
    Carrel A, Lindbergh CA. The Culture of Organs. New York: Hoeber; 1938.Google Scholar
  222. 222.
    Ackerman JR, Barnard CN. A report on the successful storage of kidneys. Br J Surg 1966;53:525–532.CrossRefGoogle Scholar
  223. 223.
    Brettschneider L, Daloze PM, Huguet C, et al. The use of combined preservation techniques for extended storage of orthotopic liver homografts. Surg Gynecol Obstet 1968;126:263–274.Google Scholar
  224. 224.
    Belzer FO, Ashby BS, Dunphy JE. 24-h and 72-h preservation of canine kidneys. Lancet 1967;2:536–538.PubMedCrossRefGoogle Scholar
  225. 225.
    Collins GM, Bravo-Shugarman T, Terasaki PI. Kidney preservation for transportation: initial perfusion and 30 h ice storage. Lancet 1969;2:1219–1224.PubMedCrossRefGoogle Scholar
  226. 226.
    Schalm SW. A Simple and Clinically Applicable Method for the Preservation of a Liver Homograft [thesis]. Holland: University of Leyden; 1968.Google Scholar
  227. 227.
    Benichou J, Halgrimson CG, Weil R III, Koep LJ, Starzl TE. Canine and human liver preservation for 6–19 h by cold infusion. Transplantation 1977;24:407–411.PubMedCrossRefGoogle Scholar
  228. 228.
    Wall WJ, Calne RY, Herbertson BM, et al. Simple hypothermic preservation for transporting human livers long distances for transplantation. Transplantation 1977;23:210–216.PubMedCrossRefGoogle Scholar
  229. 229.
    Jamieson NV, Sundberg R, Lindell S, et al. Successful 24-to 30-h preservation of the canine liver: a preliminary report. Transplant Proc 1988;29(suppl 1):945–947.Google Scholar
  230. 230.
    Kalayoglu M, Sollinger WH, Stratta RJ, et al. Extended preservation of the liver for clinical transplantation. Lancet 1988;1:617–619.PubMedGoogle Scholar
  231. 231.
    Todo S, Nery J, Yanaga K, Podesta L, Gordon RD, Starzl TE. Extended preservation of human liver grafts with UW solution. JAMA 1989;261:711–714.PubMedCrossRefGoogle Scholar
  232. 232.
    Hoffman B, Sollinger H, Kalayoglu M, Belzer FO. Use of UW solutionfor kidney transplantation. Transplantation 1988;46:338–339.PubMedCrossRefGoogle Scholar
  233. 233.
    Wahlberg JA, Love R, Landegaard L, Southard JH, Belzer FO. 72-h preservation of the canine pancreas. Transplantation 1987;43:5–8.PubMedCrossRefGoogle Scholar
  234. 234.
    Ploeg RJ, Goossens D, McAnulty JF, Southard JH, Belzer FO. Successful 72-h cold storage of dog kidneys with UW solution. Transplantation 1988;46:191–196.PubMedCrossRefGoogle Scholar
  235. 235.
    Ueda Y, Todo S, Imventarza O, et al. The UW solution for canine kidney preservation: its specific effect on renal hemodynamics and microvasculature. Transplantation 1989;48:913–918.PubMedCrossRefGoogle Scholar
  236. 236.
    Belzer FO, Southard JH. Principles of solid-organ preservation by cold storage. Transplantation 1988;45:673–676.PubMedCrossRefGoogle Scholar
  237. 237.
    Todo S, Podesta L, Ueda Y, et al. A comparison of UW with other solutions for liver preservation in dogs. Clin Transplant 1989;3:253–259.Google Scholar
  238. 238.
    Starzl TE, Nalesnik MA, Porter KA, et al. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1984;1:583–587.PubMedCrossRefGoogle Scholar
  239. 239.
    Starzl TE. The mother lode of liver transplantation: with particular reference to our new journal. Liver Transplant Surg 1998;4:1–14.CrossRefGoogle Scholar
  240. 240.
    Starzl TE, Marchioro TL, Rowlands DT Jr, et al. Immunosuppression after experimental and clinical homotransplantation of the liver. Ann Surg 1964;160:411–439.PubMedCrossRefGoogle Scholar
  241. 241.
    Marchioro TL, Porter KA, Dickinson TC, Faris TD, Starzl TE. Physiologic requirements for auxiliary liver homotransplantation. Surg Gynecol Obstet 1965;121:17–31.PubMedGoogle Scholar
  242. 242.
    Starzl TE, Francavilla A, Halgrimson CG, et al. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 1973;137:179–199.PubMedGoogle Scholar
  243. 243.
    Starzl TE, Porter KA, Putnam CW. Intraportal insulin protects from the liver injury of portacaval shunt in dogs. Lancet 1975;2:1241–1246.PubMedCrossRefGoogle Scholar
  244. 244.
    Francavilla A, Hagiya M, Porter KA, Polimeno L, Ihara I, Starzl TE. Augmenter of liver regeneration (ALR): its place in the universe of hepatic growth factors. Hepatology 1994;20:747–757.PubMedCrossRefGoogle Scholar
  245. 245.
    Starzl TE, Jones AF, Terblanche J, Usui S, Porter KA, Mazzoni G. Growth-stimulating factor in regenerating canine liver. Lancet 1979;1:127–130.PubMedCrossRefGoogle Scholar
  246. 246.
    Hagiya M, Francavilla A, Polimeno L, et al. Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biology active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci USA 1994;91:8142–8146.PubMedCrossRefGoogle Scholar
  247. 247.
    Giorda R, Hagiya M, Seki T, et al. Analysis of the structure and expression of the ALR gene. Mol Med 1966;2:97–108.Google Scholar
  248. 248.
    Starzl TE, Demetris AJ, Van Thiel DH. Medical progress: liver transplantation. N Engl J Med 1989;321 (pt I):1014–1022.PubMedGoogle Scholar
  249. 249.
    Starzl TE, Bilheimer DW, Bahnson HT, et al. Heart-liver transplantation in a patient with familial hypercholesterolemia. Lancet 1984;1:1382–1383.PubMedCrossRefGoogle Scholar
  250. 250.
    Bilheimer DW, Goldstein JL, Grundy SC, Starzl TE, Brown MS. Liver transplantation provides low-density-lipoprotein receptors and lowers plasma cholesterol in a child with homozygous familial hypercholesterolemia. N Engl J Med 1984;311:1658–1664.PubMedGoogle Scholar
  251. 251.
    Starzl TE. The little drummer girls. In: The Puzzle People. Pittsburgh: University of Pittsburgh Press; 1992:318–333.Google Scholar
  252. 252.
    Snell GD. Methods for the study of histocompatibility genes. J Genet 1948;49:87–103.PubMedCrossRefGoogle Scholar
  253. 253.
    Brent L. Immunogenetics: histocompatibility antigens—genetics, structure and function. In: A History of Transplantation Immunology. London: Academic Press; 1997:131–182.CrossRefGoogle Scholar
  254. 254.
    Dausset J. Iso-leuco-anticorps. Acta Haematol 1958;20:156.PubMedCrossRefGoogle Scholar
  255. 255.
    Van Rood JJ, Eernisses JG, van Leeuwen A. Leucocyte antibodies in sera of pregnant women. Nature 1958;181:1735.CrossRefGoogle Scholar
  256. 256.
    Terasaki PI, McClelland JD. Microdroplet assay of human serum cytoxins. Nature 1964;204:998–1000.PubMedCrossRefGoogle Scholar
  257. 257.
    Starzl TE, Marchioro TL, Holmes JH, et al. Renal homografts in patients with major donor-recipient blood group incompatibilities [addendum]. Surgery 1964;55:195–200.PubMedGoogle Scholar
  258. 258.
    Starzl TE, Ishikawa M, Putnam CW, et al. Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc 1974;6:129–139.PubMedGoogle Scholar
  259. 259.
    Rapaport FT, Dausset J, Legrand L, Barge A, Lawrence HS, Converse JM. Erythrocytes in human transplantation: effects of pretreatment with ABO group-specific antigens. J Clin Invest 1968;47:2202–2216.Google Scholar
  260. 260.
    Terasaki PI, Marchioro TL, Starzl TE. Sero-typing of human lymphocyte antigens: preliminary trials on long-term kidney homograft survivors. In: Histocompatibility Testing. Washington, DC: National Academy of Science Research Council; 1965:83–96.Google Scholar
  261. 261.
    Kissmeyer-Nielsen F, Olsen S, Peterson VP, Fieldborg O. Hyperacute rejection of kidney allografts associated with preexisting humoral antibodies against donor cells. Lancet 1966;2:662–665.PubMedCrossRefGoogle Scholar
  262. 262.
    Willimas GM, Hume DM, Hudson RP, Morris PJ, Kano K, Milgrom F. “Hyperacute” renal-homograft rejection in man. N Engl J Med 1968;279:611–618.CrossRefGoogle Scholar
  263. 263.
    Starzl TE, Lerner RA, Dixon FJ, Groth CG, Brettschneider L, Terasaki PI. Shwartzman reaction after human renal transplantation. N Engl J Med 1968;278:642–648.PubMedCrossRefGoogle Scholar
  264. 264.
    Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969;280:735–739.PubMedGoogle Scholar
  265. 265.
    Simpson KM, Bunch DL, Amemiya H, et al. Humoral antibodies and coagulation mechanisms in the accelerated or hyperacute rejection of renal homografts in sensitized canine recipients. Surgery 1970;68:77–85.PubMedGoogle Scholar
  266. 266.
    Boehmig HJ, Giles GR, Amemiya H, et al. Hyperacute rejection of renal homografts: with particular reference to coagulation changes, humoral antibodies, and formed blood elements. Transplant Proc 1971;3:1105–1117.PubMedGoogle Scholar
  267. 267.
    Starzl TE, Boehmig HJ, Amemiya H, et al. Clotting changes, including disseminated intravascular coagulation, during rapid renal-homograft rejection. N Engl J Med 1970;283:383–390.PubMedGoogle Scholar
  268. 268.
    Myburgh JA, Cohen I, Gecelther L, et al. Hyperacute rejection in human-kidney allografts Shwartzman or Arthus reaction? N Engl J Med 1969;281:131–134.PubMedCrossRefGoogle Scholar
  269. 269.
    Cerilli J, Brasile L, Galouzis T, Lempert N, Clarke J. The vascular endothelial cell antigen system. Transplantation 1985;39:286–289.PubMedCrossRefGoogle Scholar
  270. 270.
    Brasile L, Zerbe T, Rabin B, Clarke J, Abrahms A, Cerilli J. Identification of the antibody to vascular endothelial cells in patients undergoing cardiac transplantation. Transplantation 1985;40:672–675.PubMedCrossRefGoogle Scholar
  271. 271.
    Knechtle SJ, Halperin EC, Bollinger RR. Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporin. Transplantation 1987;43:173–175.PubMedCrossRefGoogle Scholar
  272. 272.
    Gubernatis G, Lauchart W, Jonker M, et al. Signs of hyperacute rejection of liver grafts of Rhesus monkeys after donor-specific presensitization. Transplant Proc 1987;19:1082–1083.PubMedGoogle Scholar
  273. 273.
    Merion RM, Colletti LM. Demonstration of hyperacute rejection (HAR) in outbred large animal model of liver transplantation (LTX). Transplantation 1990;49:861–868.PubMedCrossRefGoogle Scholar
  274. 274.
    Takaya S, Bronsther O, Iwaki Y, et al. The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. Transplantation 1992;53:400–406.PubMedCrossRefGoogle Scholar
  275. 275.
    Starzl TE, Demetris AJ, Todo S, et al. Evidence for hyperacute rejection of human liver grafts: the case of the canary kidneys. Clin Transplant 1989;3:37–45.Google Scholar
  276. 276.
    Starzl TE. Tissue matching. In: The Puzzle People. Pittsburgh: University of Pittsburgh Press; 1992:118–124.Google Scholar
  277. 277.
    Brent L. Immunogenetics: histocompatibility antigens—structure and function. In: A History of Transplantation Immunology. London: Academic Press; 1997:153–159.Google Scholar
  278. 278.
    Starzl TE, Marchioro TL, Terasaki PI, et al. Chronic survival after human renal homo transplantations: lymphocyte-antigen matching, pathology and influence of thymectomy. Ann Surg 1965;162:749–787.PubMedCrossRefGoogle Scholar
  279. 279.
    Terasaki PI, Vredevoe DL, Mickey MR, et al. Serotyping for homotransplantation: selection of kidney donors for thirty-two recipients. Ann N Y Acad Sci 1966;129:500–520.CrossRefGoogle Scholar
  280. 280.
    Rapaport FT, Lawrence HS, Thomas L, Converse JM, Tillett WS, Mulholland JH. Cross-reactions to skin homografts in man. J Clin Invest 1962;41:2166–2172.PubMedCrossRefGoogle Scholar
  281. 281.
    Dausset J, Rapaport FT. The Hu-1 system of human histocompatibility. In: Rapaport FT, Dausset J, eds. Human Transplantation. New York: Grune and Stratton; 1968:369.Google Scholar
  282. 282.
    Rapaport FT, Dausset J. Behavior of HLA-compatible and incompatible skin allografts in human recipients preimmunized with pooled leukocyte extracts obtained from randomly selected donors. Transplantation 1983;36:592–594.PubMedCrossRefGoogle Scholar
  283. 283.
    Starzl TE, Porter KA, Andres G, et al. Long-term survival after renal transplantation in humans: with special reference to histocompatibility matching, thymectomy, homograft glomerulonephritis, heterologous ALG, and recipient malignancy. Ann Surg 1970;172:437–472.PubMedCrossRefGoogle Scholar
  284. 284.
    Mickey MR, Kreisler M, Albert ED, Tanaka N, Terasaki PI. Analysis of HL-A incompatibility in human renal transplants. Tissue Antigens 1971;1:57–67.PubMedCrossRefGoogle Scholar
  285. 285.
    Starzl TE, Eliasziw M, Gjertson M, et al. HLA and cross reactive antigen group (CREG) matching for cadaver kidney allocation. Transplantation 1997;64:983–991.PubMedCrossRefGoogle Scholar
  286. 286.
    Starzl TE, Demetris AJ, Murase N, Ricordi C, Trucco M. The enigma of graft acceptance. In: Shumway SJ, Shumway NE, eds. Thoracic Transplantation. London: Blackwell Science; 1995:452–470.Google Scholar
  287. 287.
    Starzl TE, Demetris AJ, Trucco M, et al. Systemic chimerism in human female recipients of male livers. Lancet 1992;340:876–877.PubMedCrossRefGoogle Scholar
  288. 288.
    Starzl TE, Demetris AJ, Trucco M, et al. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 1993;55:1272–1277.PubMedCrossRefGoogle Scholar
  289. 289.
    Starzl TE, Demetris AJ, Trucco M, et al. Chimerism after liver transplantation for type IV glycogen storage disease and type I Gaucher’s disease. N Engl J Med 1993;328:745–749.PubMedCrossRefGoogle Scholar
  290. 290.
    Demetris AJ, Murase N, Starzl TE. Donor dendritic cells after liver and heart allotransplantation under short-term immunosuppression. Lancet 1992;339:1610.CrossRefGoogle Scholar
  291. 291.
    Demetris AJ, Murase N, Fujisaki S, Fung JJ, Rao AS, Starzl TE. Hematolymphoid cell trafficking, microchimerism, and GVHD reactions after liver, bone marrow, and heart transplantation. Transplant Proc 1993;25:3337–3344.PubMedGoogle Scholar
  292. 292.
    Qian S, Demetris AJ, Murase N, Rao AS, Fung JJ, Starzl TE. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994;19:916–924.PubMedCrossRefGoogle Scholar
  293. 293.
    Murase N, Starzl TE, Tanabe M, et al. Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown-Norway rats. Transplantation 1995;60:158–171.PubMedGoogle Scholar
  294. 294.
    Michie D, Woodruff MFA, Zeiss IM. An investigation of immunological tolerance based on chimera analysis. Immunology 1961;4:413–424.PubMedGoogle Scholar
  295. 295.
    Simonsen M. Graft versus host reactions: their natural history, and applicability as tools of research. Prog Allergy 1962;6:349–467.PubMedCrossRefGoogle Scholar
  296. 296.
    Bain B, Vas MR, Lowenstein L. The development of large immature mononuclear cells in mixed leukocyte cultures. Blood 1964;23:108–116.PubMedGoogle Scholar
  297. 297.
    Bach F, Hirschhorn K. Lymphocyte interaction: a potential histocompatibility test in vitro. Science 1964;143:813–814.PubMedCrossRefGoogle Scholar
  298. 298.
    Martinez C, Shapiro F, Good RA. Essential duration of parabiosis and development of tolerance to skin homografts in mice. Proc Soc Exp Biol Med 1960;104:256–259. !!!!!!!!!!!!!PubMedGoogle Scholar
  299. 299.
    Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature (Lond) 1984;307:168–170.PubMedCrossRefGoogle Scholar
  300. 300.
    Thomas J, Carver M, Cunningham P, Park K, Gonder J, Thomas F. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow: in vivo parameters and immunohistologic evidence suggesting microchimerism. Transplantation (Baltimore) 1987;43:332–338.PubMedCrossRefGoogle Scholar
  301. 301.
    Przepiorka D, Thomas ED, Durham DM, Fisher L. Use of a probe to repeat sequence of the Y chromosome for detection of host cells in peripheral blood of bone marrow transplant recipients. Am J Clin Pathol 1991;95:201–206.PubMedGoogle Scholar
  302. 302.
    Lawrence HS. Homograft sensitivity: an expression of the immunologic origins and consequences of individuality. Physiol Rev 1959;39:811–859.PubMedGoogle Scholar
  303. 303.
    Medawar PB. The immunology of transplantation. In: The Harvey Lectures. Series 52. New York: Academic Press; 1956–1957:144–166.Google Scholar
  304. 304.
    Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system. Nature 1974;248:701–702.PubMedCrossRefGoogle Scholar
  305. 305.
    Zinkernagel RM. Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes. Nature 1974;251:230–233.PubMedCrossRefGoogle Scholar
  306. 306.
    Doherty PC, Zinkernagel RM. A biological role for the major histocompatibility antigens. Lancet 1975;1:1406–1409.PubMedCrossRefGoogle Scholar
  307. 307.
    Zinkernagel RM, Doherty PC. The discovery of MHC restriction. Immunol Today 1997;18:14–17.PubMedCrossRefGoogle Scholar
  308. 308.
    Zinkernagel RM. Immunology taught by viruses. Science 1996;271:173–178.PubMedCrossRefGoogle Scholar
  309. 309.
    Zinkernagel RM, Ehl S, Aichele P, Oehen S, Kundig T, Hengartner H. Antigen localization regulates immune responses in a dose-and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev 1997;156:199–209.PubMedCrossRefGoogle Scholar
  310. 310.
    Starzl TE, Rao AS, Murase N, Fung J, Demetris AJ. Will xenotransplantation ever be feasible? J Am Coll Surg 1998;186:383–387.PubMedCrossRefGoogle Scholar
  311. 311.
    Sterzl J, Silverstein AM. Development aspects of immunity. Adv Immunol 1967;6:337–459.PubMedCrossRefGoogle Scholar
  312. 312.
    Matzinger P. Tolerance, danger, and the extended family. Ann Rev Immunol 1994;12:991–1045.Google Scholar
  313. 313.
    Ridge JP, Fuchs Ef, Matzinger P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996;271:1723–1726.PubMedCrossRefGoogle Scholar
  314. 314.
    Starzl TE. Zinkernagel R. Antigen localization and migration in immunity and tolerance. N Engl J Med 1998;339:1905–1913.PubMedCrossRefGoogle Scholar
  315. 315.
    Starzl TE, Zinkernagel R: Transplantation tolerance from a historical perspective. Nat Rev Immunol 2001;1:233–239.PubMedCrossRefGoogle Scholar
  316. 316.
    Starzl TE. Organ transplantation: a practical triumph and epistemologic collapse. Proc Am Philos Soc 2003;147:226–245.PubMedGoogle Scholar
  317. 317.
    Starzl TE. The saga of liver replacement, with particular reference to the reciprocal influence of liver and kidney transplantation (1955–1967). J Am Coll Surg 2002;195:587–610.PubMedCrossRefGoogle Scholar
  318. 318.
    Starzl TE, Murase N, Abu-Elmagd K, et al. Tolerogenic immunosuppression for organ transplantation. Lancet 2003;361:1502–1510.PubMedCrossRefGoogle Scholar
  319. 319.
    Starzl TE, Lakkis FG. The unfinished legacy of liver transplantation: emphasis on immunology. Hepatology 2006;43(2 Suppl 1):S151–163.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Thomas E. Starzl
    • 1
  1. 1.Department of Surgery, Thomas E. Starzl Transplantation InstituteUniversity of PittsburghPittsburghUSA

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