Surgery pp 1375-1395 | Cite as

Diseases of the Great Vessels and the Thoracic Outlet

  • Spencer J. Melby
  • Robert W. Thompson


The aortic arch and its branches are a common location for the development of atherosclerosis. Similar to atherosclerosis in other areas of the arterial tree, the pathology ranges from mild, nonocclusive intimal thickening to complex atheromata. Complex atheromatous plaques may evolve to a size large enough to encroach upon the lumen, thereby restricting flow, or they may be complicated by intraplaque hemorrhage, ulceration and discharge of atheromatous debris, and surface thrombosis. Well-established clinical risk factors for atherosclerosis include family history, aging, cigarette smoking, hypertension, hyperlipidemia, and diabetes.


Subclavian Artery Giant Cell Arteritis Innominate Artery Thoracic Outlet Syndrome Temporal Arteritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Spencer J. Melby
    • 1
  • Robert W. Thompson
    • 2
    • 3
    • 4
  1. 1.Department of General SurgeryBarnes-Jewish Hospital and Washington University School of MedicineSt. LouisUSA
  2. 2.Departments of Surgery (Section of Vascular Surgery), Radiology, and Cell Biology and PhysiologyBarnes-Jewish Hospital and Washington University School of MedicineSt. LouisUSA
  3. 3.Department of SurgeryBarnes-Jewish Hospital and Washington University School of MedicineSt. LouisUSA
  4. 4.Barnes-Jewish Hospital and Washington University School of MedicineSt. LouisUSA

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