Surgery pp 1317-1336 | Cite as

Pathobiology of Vascular Disease

  • Bryan W. Tillman
  • Randolph L. Geary


Knowledge of the structure and function of the circulatory system and the consequences of temporary or permanent disruption of regional blood flow is imperative in surgery because operative procedures by their very nature disrupt tissues and their blood supply. Moreover, reconstruction of blood vessels is often necessary as they fail from disease or trauma. Repair or replacement requires an understanding of vascular anatomy, vessel wall structure, hemodynamics, and the healing properties of vessels and grafts. This chapter focuses on the arterial system, providing an overview of its origin, structure, and function. The pathobiology of common artery wall diseases is then considered. Subsequent chapters focus on contemporary evidence-based management of regional artery wall pathology.


Smooth Muscle Cell Abdominal Aortic Aneurysm Vein Graft Intimal Hyperplasia Artery Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Bryan W. Tillman
    • 1
  • Randolph L. Geary
    • 2
  1. 1.Department of SurgeryWake Forest University Medical CenterWinston-SalemUSA
  2. 2.Department of General SurgeryWake Forest University School of MedicineWinston-SalemUSA

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