Surgery pp 101-109 | Cite as

Substrate Metabolism

  • Edward Lin
  • Stephen F. Lowry


The initial hours following surgical or traumatic injury are associated metabolically with reduced total body energy expenditure and increased urinary nitrogen wasting. This initial phase of injury also demonstrates an augmented release of neuroendocrine hormones, including catecholamines and Cortisol. On adequate resuscitation and stabilization of the injured patient, a reprioritization of substrate utilization occurs to preserve vital organ function and for the repair of injured tissue.1 This phase of recovery is also characterized by augmented metabolic rates and oxygen consumption, enhanced enzymatic pathways for readily oxidizable substrates such as glucose, and stimulation of immune system functions that participate in the restoration of homeostasis.


Free Fatty Acid Glycogen Store Fuel Source Hepatic Gluconeogenesis Cori Cycle 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Edward Lin
    • 1
  • Stephen F. Lowry
    • 2
  1. 1.Department of SurgeryEmory University School of MedicineAtlantaUSA
  2. 2.Department of SurgeryUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolNew Brunswick

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