Tip Functionalization: Applications to Chemical Force Spectroscopy

  • Craig D. Blanchette
  • Albert Loui
  • Timothy V. Ratto

Adhesion events in chemistry, biology, and material science occur through intermolecular interactions between distinct chemical functionalities. Chemical force spectroscopy has recently emerged as a powerful and versatile tool for the quantitative characterization of these molecular forces. Based on atomic force microscopy (AFM), chemical force spectroscopy relies on the modification of probe tips as a means of introducing chemical specificity into force measurements. In practice, a chemically modified tip is brought into contact with a substrate of specific functionality and as the tip is withdrawn, the interaction force between the functionalized tip and substrate is measured.


Atomic Force Microscopy Force Spectroscopy Rupture Force Vinyl Sulfone Biophysical Journal 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Craig D. Blanchette
    • 1
  • Albert Loui
    • 2
  • Timothy V. Ratto
    • 3
  1. 1.Chemistry, Materials and Life Sciences DirectorateLawrence Livermore National LaboratoryLivermoreUSA
  2. 2.Chemistry, Materials and Life Sciences DirectorateLawrence Livermore National LaboratoryLivermoreUSA
  3. 3.Chemistry, Materials and Life Sciences DirectorateLawrence Livermore National LaboratoryLivermoreUSA

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