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Surface Force Apparatus Measurements of Molecular Forces in Biological Adhesion

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Handbook of Molecular Force Spectroscopy

Adhesion is essential in biology. Intercellular interactions maintain the structural hierarchy of all multicellular organisms across all anatomical length scales. Cells transduce mechanical signals and respond by regulating adhesion, motility, and differentiation. Other adhesive interactions are central to immunity. Pathogenic microorganisms use adhesive interactions with cells in the first steps in infection. Determining the molecular mechanisms underlying these processes is central to understanding the fundamental basis of related diseases and to developing strategies to treating or preventing disease.

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  1. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 127 Roger Adams Lab MC-712, C-3 600, S. Mathews Ave., Urbana, IL, 61801, USA

    Deborah Leckband

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  1. Chemistry, Materials and Life Sciences Directorate, Lawerence Livermore National Laboratory, Livermore, CA, USA

    Aleksandr Noy

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Leckband, D. (2008). Surface Force Apparatus Measurements of Molecular Forces in Biological Adhesion. In: Noy, A. (eds) Handbook of Molecular Force Spectroscopy. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-49989-5_1

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