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Surface Force Apparatus Measurements of Molecular Forces in Biological Adhesion

  • Deborah Leckband

Adhesion is essential in biology. Intercellular interactions maintain the structural hierarchy of all multicellular organisms across all anatomical length scales. Cells transduce mechanical signals and respond by regulating adhesion, motility, and differentiation. Other adhesive interactions are central to immunity. Pathogenic microorganisms use adhesive interactions with cells in the first steps in infection. Determining the molecular mechanisms underlying these processes is central to understanding the fundamental basis of related diseases and to developing strategies to treating or preventing disease.

Keywords

Neural Cell Adhesion Molecule Adhesion Energy Molecular Force Polysialic Acid Steer Molecular Dynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Deborah Leckband
    • 1
  1. 1.Department of Chemical and Biomolecular EngineeringUniversity of Illinois at Urbana-Champaign, 127 Roger Adams Lab MC-712UrbanaUSA

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