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Pediatric Otitis Media with Effusion

  • Jennifer J. Shin
  • Michael J. Cunningham
  • Christopher J. Hartnick
  • Grace Chan
  • Margaret Kenna

Abstract

A computerized Ovid search of MEDLINE 1966–January 2004 was performed. The terms “otitis media” and “antibiotics” were exploded and the resulting articles were cross-referenced, yielding 1947 trials. Given the known richness of the otitis media literature and the authority of higher levels of evidence, these articles were then limited to randomized controlled trials (RCTs), resulting in 302 articles. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population <18 years of age with documented otitis media with effusion (OME), 2) intervention with amoxicillin therapy alone versus placebo control, 3) outcome measured in terms of presence or absence of middle ear effusion (MEE) with a statistical analysis. Articles comparing intervention with amoxicillin/clavulanate, cephalosporins, trimethoprim-sulfamethoxazole, and erythromycin with placebo were excluded here but are presented separately in this chapter. The bibliographies of articles that met these inclusion criteria were manually examined to determine if any further relevant articles could be identified.

Keywords

Hearing Loss Otitis Medium Acute Otitis Medium Otitis Medium With Effusion Chronic Otitis Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jennifer J. Shin
    • 1
  • Michael J. Cunningham
    • 2
  • Christopher J. Hartnick
    • 2
  • Grace Chan
    • 3
  • Margaret Kenna
    • 4
  1. 1.Harvard Program in Otolaryngology-Head and Neck SurgeryMassachusetts Eye and Ear InfirmaryBostonUSA
  2. 2.Department of OtolaryngologyMassachusetts Eye and Ear InfirmaryBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA
  4. 4.Department of Otolaryngology and Communication DisordersThe Children’s HospitalBostonUSA

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