Abstract
A computerized Ovid search of MEDLINE 1966-Junuary 2004 was performed. The terms “otitis media” and “antibiotics” were exploded and the resulting articles were cross-referenced, yielding 1947 trials. Given the known richnes sof the otitis media literature and the authority of higher levels of evidence, these artiles were then limited to randomized controlled trials (RCTs), resulting in 302 articles. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population <18 years of age with documented recurrent acute otitis media (RAOM), 2) intervention with continuous amoxicillin or ampicillin prophylaxis versus placebo control, 3) outcome measured in terms of the number of episodes of acute otitis media (AOM). Articles in which noncontinuous antibiotic therapy was administered were excluded, as were articles that included patients on the basis of chronic middle ear effusion (MEE) alone. Also excluded were articles that were not placebo controlled, as well as those that enrolled children with nonrecurrent AOM (i.e, only one previous episode).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Roark R, Berman S. Continuous twice daily or once daily amoxicillin prophylaxis compared with placebo for children with recurrent acute otitis media. Pediatr Infect Dis J 1997;16(4):376–381.
Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. Pediatr Infect Dis J 1992; 11(4):278–286.
Maynard JE, Fleshman JK, Tschopp CF. Otitis media in Alaskan Eskimo children. Prospective evaluation of chemoprophylaxis. JAMA 1972;219(5):597–599.
Sih T, Moura R, Caldas S, Schwartz B. Prophylaxis for recurrent acute otitis media: a Brazilian study. Int J Pediatr Otorhinolaryngol 1993;25(1–3):19–24.
Principi N, Marchisio P, Massironi E, Grasso RM, Filiberti G. Prophylaxis of recurrent acute otitis media and middle-ear effusion. Comparison of Amoxicillin with sulfamethoxazole and trimethoprim. Am J Dis Child 1989; 143(12):1414–1418.
References
Gonzalez C, Arnold JE, Woody EA, et al. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.
Liston TE, Foshee WS, Pierson WD, Sulfisoxazole chemoprophylaxis for frequent otitis media. Pediatrics 1983;71(4): 524–530.
Perrin JM, Charney E, MacWhinney JBJr, McInerny TK, Miller RL, Nazarian LF. Sulfisoxazole as chemoprophylaxis for recurrent otitis media. A double-blind crossover study in pediatric practice. N Engl J Med 1974;291(13):664–667.
Varsano I, Volovitz B, Mimouni F. Sulfisoxazole prophylaxis of middle ear effusion and recurrent acute otitis media. Am J Dis Child 1985;139(6):632–635.
References
Principi N, Marchisio P, Massironi E, Grasso RM, Filiberti G. Prophylaxis of recurrent acute otitis media and middleear effusion. Comparison of Amoxicillin with sulfamethoxazole and trimethoprim. Am J Dis Child 1989;143(12): 1414–1418.
Sih T, Moura R, Caldas S, Schwartz B. Prophylaxis for recurrent acute otitis media: a Brazilian study. Int J Pediatr Otorhinolaryngol 1993;25(1–3):19–24.
References
Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. [see comment.] Pediatr Infec dis J 1992;11(4):278–286.
Gonzalez C, Arnold JE, Woody EA, Erhardt JB, Pratt SR, Getts A, Kueser TJ, Kolmer JW, Sachs M. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.
Gebhart DE, Tympanostomy tubes in the otitis media prone child. Laryngoscope 1981;91(6):849–866
References
Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. [see comment.] Pediatr Infect Dis J 1992;11(4):278–286.
Gonzalez C, Arnold JE, Woody EA, et al. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.
References
Koivunen P, Uhari M, Luotonen J, et al. Adenoidectomy versus chemoprophylaxis and placebo for recurrent acute otitis media in children aged under 2 years: randomised controlled trial. BMJ, 2004;328(7438):487.
Mattila PS, Joki-Erkkila VP, Kilpi T, Jokinen J, Herva E, Puhakka H. Prevention of otitis media by adenoidectomy in children younger than 2 years. Arch Otolaryngol Head Neck Surg 2003;129(2):163–168.
Paradise JL, Bluestone CD, Colborn DK, et al. Adenoidectomy and adenotonsillectomy for recurrent acute otitis media: parallel randomized clinical trials in children not previously treated with tympanostomytubes. [see comment]. JAMA 1999;282(10):945–953.
Paradise JL, Bluestone CD, Rogers KD, et al. Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. JAMA 1990;263(15):2066–2073.
Reference
Paradise JL, Bluestone CD, Rogers KD, et al. Efficacy of adenoidectomy for recurrent otitis media in children previously ously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. JAMA 1990;263(15):2066–2073.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Shin, J.J., Stinnett, S.S., Hartnick, C.J. (2008). Pediatric Recurrent Acute Otitis Media. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_6
Download citation
DOI: https://doi.org/10.1007/978-0-387-49979-6_6
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-24447-1
Online ISBN: 978-0-387-49979-6
eBook Packages: MedicineMedicine (R0)