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Pediatric Recurrent Acute Otitis Media

  • Jennifer J. Shin
  • Sandra S. Stinnett
  • Christopher J. Hartnick

Abstract

A computerized Ovid search of MEDLINE 1966-Junuary 2004 was performed. The terms “otitis media” and “antibiotics” were exploded and the resulting articles were cross-referenced, yielding 1947 trials. Given the known richnes sof the otitis media literature and the authority of higher levels of evidence, these artiles were then limited to randomized controlled trials (RCTs), resulting in 302 articles. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population <18 years of age with documented recurrent acute otitis media (RAOM), 2) intervention with continuous amoxicillin or ampicillin prophylaxis versus placebo control, 3) outcome measured in terms of the number of episodes of acute otitis media (AOM). Articles in which noncontinuous antibiotic therapy was administered were excluded, as were articles that included patients on the basis of chronic middle ear effusion (MEE) alone. Also excluded were articles that were not placebo controlled, as well as those that enrolled children with nonrecurrent AOM (i.e, only one previous episode).

Keywords

Down Syndrome Otitis Medium Tympanic Membrane Acute Otitis Medium Incidence Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Roark R, Berman S. Continuous twice daily or once daily amoxicillin prophylaxis compared with placebo for children with recurrent acute otitis media. Pediatr Infect Dis J 1997;16(4):376–381.CrossRefPubMedGoogle Scholar
  2. 2.
    Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. Pediatr Infect Dis J 1992; 11(4):278–286.PubMedGoogle Scholar
  3. 3.
    Maynard JE, Fleshman JK, Tschopp CF. Otitis media in Alaskan Eskimo children. Prospective evaluation of chemoprophylaxis. JAMA 1972;219(5):597–599.CrossRefPubMedGoogle Scholar
  4. 4.
    Sih T, Moura R, Caldas S, Schwartz B. Prophylaxis for recurrent acute otitis media: a Brazilian study. Int J Pediatr Otorhinolaryngol 1993;25(1–3):19–24.CrossRefPubMedGoogle Scholar
  5. 5.
    Principi N, Marchisio P, Massironi E, Grasso RM, Filiberti G. Prophylaxis of recurrent acute otitis media and middle-ear effusion. Comparison of Amoxicillin with sulfamethoxazole and trimethoprim. Am J Dis Child 1989; 143(12):1414–1418.PubMedGoogle Scholar

References

  1. 1.
    Gonzalez C, Arnold JE, Woody EA, et al. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.PubMedGoogle Scholar
  2. 2.
    Liston TE, Foshee WS, Pierson WD, Sulfisoxazole chemoprophylaxis for frequent otitis media. Pediatrics 1983;71(4): 524–530.PubMedGoogle Scholar
  3. 3.
    Perrin JM, Charney E, MacWhinney JBJr, McInerny TK, Miller RL, Nazarian LF. Sulfisoxazole as chemoprophylaxis for recurrent otitis media. A double-blind crossover study in pediatric practice. N Engl J Med 1974;291(13):664–667.PubMedCrossRefGoogle Scholar
  4. 4.
    Varsano I, Volovitz B, Mimouni F. Sulfisoxazole prophylaxis of middle ear effusion and recurrent acute otitis media. Am J Dis Child 1985;139(6):632–635.PubMedGoogle Scholar

References

  1. 1.
    Principi N, Marchisio P, Massironi E, Grasso RM, Filiberti G. Prophylaxis of recurrent acute otitis media and middleear effusion. Comparison of Amoxicillin with sulfamethoxazole and trimethoprim. Am J Dis Child 1989;143(12): 1414–1418.PubMedGoogle Scholar
  2. 2.
    Sih T, Moura R, Caldas S, Schwartz B. Prophylaxis for recurrent acute otitis media: a Brazilian study. Int J Pediatr Otorhinolaryngol 1993;25(1–3):19–24.CrossRefPubMedGoogle Scholar

References

  1. 1.
    Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. [see comment.] Pediatr Infec dis J 1992;11(4):278–286.CrossRefGoogle Scholar
  2. 2.
    Gonzalez C, Arnold JE, Woody EA, Erhardt JB, Pratt SR, Getts A, Kueser TJ, Kolmer JW, Sachs M. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.PubMedGoogle Scholar
  3. 3.
    Gebhart DE, Tympanostomy tubes in the otitis media prone child. Laryngoscope 1981;91(6):849–866CrossRefPubMedGoogle Scholar

References

  1. 1.
    Casselbrant ML, Kaleida PH, Rockette HE, et al. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. [see comment.] Pediatr Infect Dis J 1992;11(4):278–286.PubMedGoogle Scholar
  2. 2.
    Gonzalez C, Arnold JE, Woody EA, et al. Prevention of recurrent acute otitis media: chemoprophylaxis versus tympanostomy tubes. Laryngoscope 1986;96(12):1330–1334.PubMedGoogle Scholar

References

  1. 1.
    Koivunen P, Uhari M, Luotonen J, et al. Adenoidectomy versus chemoprophylaxis and placebo for recurrent acute otitis media in children aged under 2 years: randomised controlled trial. BMJ, 2004;328(7438):487.CrossRefPubMedGoogle Scholar
  2. 2.
    Mattila PS, Joki-Erkkila VP, Kilpi T, Jokinen J, Herva E, Puhakka H. Prevention of otitis media by adenoidectomy in children younger than 2 years. Arch Otolaryngol Head Neck Surg 2003;129(2):163–168.PubMedGoogle Scholar
  3. 3.
    Paradise JL, Bluestone CD, Colborn DK, et al. Adenoidectomy and adenotonsillectomy for recurrent acute otitis media: parallel randomized clinical trials in children not previously treated with tympanostomytubes. [see comment]. JAMA 1999;282(10):945–953.CrossRefPubMedGoogle Scholar
  4. 4.
    Paradise JL, Bluestone CD, Rogers KD, et al. Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. JAMA 1990;263(15):2066–2073.CrossRefPubMedGoogle Scholar

Reference

  1. 1.
    Paradise JL, Bluestone CD, Rogers KD, et al. Efficacy of adenoidectomy for recurrent otitis media in children previously ously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. JAMA 1990;263(15):2066–2073.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jennifer J. Shin
    • 1
  • Sandra S. Stinnett
    • 2
  • Christopher J. Hartnick
    • 3
  1. 1.Harvard Program in Otolaryngology-Head and Neck SurgeryMassachusetts Eye and Ear InfirmaryBostonUSA
  2. 2.Department of OtolaryngologyDuke University Medical CenterDurhamUSA
  3. 3.Department of OtolaryngologyMassachusetts Eye and Ear InfirmaryBostonUSA

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