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Oropharyngeal Squamous Cell Carcinoma

  • Richard Wein
  • Randal S. Weber

Abstract

A computerized PubMed search of MEDLINE April 1969–July 2005 was performed. The terms “oropharyngeal carcinoma,” “combined modality therapy,” “radiotherapy,” “chemotherapy,” and “surgical procedures, operative” were exploded and the resulting articles were cross-referenced with “survival,” “prognosis,” “recurrence,” “stage 3,” and “stage 4” yielding 237 trials. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population undergoing treatment for stage III–IV oropharyngeal carcinoma, 2) intervention with primary surgical resection and postoperative radiation therapy (RT) versus concomitant chemoradiation, 3) outcome measured in terms of locoregional recurrence and disease-free/overall survival. Articles that included data combined from other head and neck primary sites in addition to the oropharynx were excluded. Reports of oropharyngeal carcinoma in which stage III–IV patients were grouped with stage I–II patients were also excluded. Chemoradiation was defined as concomitant delivery of treatment and excluded studies performing induction chemotherapy followed by radiation alone.

Keywords

Postoperative Radiation Mucoepidermoid Carcinoma Combine Modality Therapy Oropharyngeal Squamous Cell Carcinoma Oropharyngeal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Richard Wein
    • 1
  • Randal S. Weber
    • 2
  1. 1.Department of Otolaryngology and Communicative SciencesUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Department of Head and Neck SurgeryUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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