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Perioperative Antibiotics for Otologic Surgery

  • Jennifer J. Shin
  • Marlene Durand

Abstract

A computerized PubMed search of MEDLINE 1966-November 2004 was performed. Articles mapping to any of the following medical subject headings were exploded and combined: “antibiotic prophylaxis,” “antibacterial agents,” “lactams,” “fluoroquinolones,” “macrolides,” “clindamycin.” These articles were then cross-referenced with those mapping to either the exploded medical subject heading “myringoplasty” or textword “myringoplasty.” This process yielded 21 trials. These articles were then reviewed to identify those that met the following inclusion criteria: 1) a distinct patient population under-going myringoplasty alone, 2) intervention with perioperative systemic antibiotics versus placebo or other no-antibiotic control, 3) outcome measured in terms of postoperative surgical site infections1 and/or graft success, 4) randomized controlled trials (RCTs). The outcome of graft success was considered relevant because SSIs have been correlated with graft failure. Articles in which the use of randomization was not clearly specified were excluded.

Keywords

Surgical Site Infection Acute Otitis Medium Graft Failure Postoperative Infection Systemic Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Carlin WV, Lesser TH, John DG, Fielder C, Carrick DG, Thomas PL, Hill SS. Systemic antibiotic prophylaxis and reconstructive ear surgery. Clin Otolaryngol Allied Sci 1987;12(6):441–446.CrossRefPubMedGoogle Scholar
  2. 2.
    John DG, Carlin WV, Lesser TH, Carrick DG, Fielder C. Tympanoplasty surgery and prophylactic antibiotics: surgical results. Clin Otolarngol Allied Scie 1988;13(3):205–207.CrossRefGoogle Scholar
  3. 3.
    Donaldson JA, Snyder IS. Prophylactic chemotherapy in myringoplasty surgery. Laryngoscope 1966;76:1201–1214.CrossRefGoogle Scholar
  4. 4.
    Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection. Centers for Disease Control, US Departnent of Health and Human Services, 1999.Google Scholar

References

  1. 1.
    Govaerts PJ, Raemaekers J, Verlinden A, Kalai M, Somers T, Offeciers FF. Use of antibiotic prophylaxis in ear surgery. Laryngoscope 1998;108(1):107–110.CrossRefPubMedGoogle Scholar
  2. 2.
    Jackson CG. Antimicrobial prophylaxis in ear surgery. Laryngoscope 1988;98(10):1116–1123.CrossRefPubMedGoogle Scholar
  3. 3.
    Eschelman. Prophylactic antibiotics in otolaryngologic surgery: a double blind study. Trans Am Acad Ophthalmol Otolaryngol 1971;75(2):387–394.PubMedGoogle Scholar
  4. 4.
    Lindholdt T, Felding JU, Juul A, Kristensen S, Schouenburg P. Efficacy of perioperative ceftazidime in the surgical treatment of chronic otitis media due to Pseudomonas aeriginosa. Arch Otorhinolaryngol 1986;243(3):167–169.CrossRefGoogle Scholar
  5. 5.
    Winerman I, Segal S, Man A. Effectiveness of prophylactic antibiotic treatment in mastoid surgery. Am J Otol 1981; 3(1):65–67.PubMedGoogle Scholar
  6. 6.
    Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.Google Scholar

References

  1. 1.
    Jackson CG. Antimicrobial prophylaxis in ear surgery. Laryngoscope 1988;98(10):1116–1123.CrossRefPubMedGoogle Scholar
  2. 2.
    Lindholdt T, Felding JU, Juul A, Kristensen S, Schouenburg P. Efficacy of perioperative ceftazidime in the surgical treatment of chronic otitis media due to Pseudomonas aeriginosa. Arch Otorhinolaryngol 1986;243(3):167–169.CrossRefGoogle Scholar
  3. 3.
    Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.Google Scholar

References

  1. 1.
    Bagger-Sjoback D, Mendel L, Nord CE. The role of prophylactic antibiotics in middle ear surgery. A study on phenoxymethylpenecillin prophylaxis. Am J Otol 1987; 8(6):519–523.PubMedGoogle Scholar
  2. 2.
    Carlin WV, Lesser TH, John DG, Fielder C, Carrick DG, Thomas PL, Hill SS. Systemic antibiotic prophylaxis and reconstructive ear surgery. Clin Otololaryng Allied Sci 1987;12(6):441–446.CrossRefGoogle Scholar
  3. 3.
    Donaldson JA, Snyder IS. Prophylactic chemotherapy in myringoplasty surgery. Laryngoscope 1966;76:1201–1214.CrossRefGoogle Scholar
  4. 4.
    Eschelman. Prophylactic antibiotics in otolaryngologic surgery: a double blind study. Trans Am Acad Ophthalmol Otolaryngol 1971;75(2):387–394.PubMedGoogle Scholar
  5. 5.
    Govaerts PJ, Raemaekers J, Verlinden A, Kalai M, Somers T, Offeciers FE. Use of antibiotic prophylaxis in ear surgery. Laryngoscope 1998;108(1):107–110.CrossRefPubMedGoogle Scholar
  6. 6.
    Jackson CG. Antimicrobial prophylaxis in ear surgery. Laryngoscope 1988;98(10):1116–1123.CrossRefPubMedGoogle Scholar
  7. 7.
    John DG, Carlin WV, Lesser TH, Carrick DG, Fielder C. Tympanoplasty surgery and prophylactic antibiotics: surgical results. Clin Otololaryng Allied Sci 1988;13(3): 205–207.CrossRefGoogle Scholar
  8. 8.
    Lindholdt F, Felding JU, Juul A, Kristensen S, Schouenburg P. Efficacy of perioperative ceftazidime in the surgical treatment of chronic otitis media due to Pseudomonas aeriginosa. Arch Otorhinolaryngol 1986;243(3):167–169.CrossRefGoogle Scholar
  9. 9.
    Winerman I, Segal S, Man A. Effectiveness of Prophylactic Antibiotic Treatment in Mastoid Surgery. Am J Otol 1981; 3(1):65–67.PubMedGoogle Scholar
  10. 10.
    Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.Google Scholar
  11. 11.
    Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical wound infection. N Engl J Med 1992;326(5):281–286.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jennifer J. Shin
    • 1
  • Marlene Durand
    • 2
  1. 1.Harvard Program in Otolaryngology-Head and Neck SurgeryMassachusetts Eye and Ear InfirmaryBostonUSA
  2. 2.Division of Infectious DiseaseMassachusetts General HospitalBostonUSA

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