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Tinnitus

  • Josh Finnell
  • Jay F. Piccirillo
  • Carol Bauer
  • Thomas J. Brozoski
  • Alison Perring

Abstract

A computerized PubMed search of MEDLINE 1966-October 2005 was performed. The terms “tinnitus” and “antidepressant-agents” were exploded and the resulting articles were cross-referenced, yielding 26 articles. An additional search of the following subject headings was performed: “tinnitus” was cross-referenced with the textwords and medical subject headings “antidepressive agents,” “antidepressive,” “antidepressant,” “amitriptyline,” “clomipramine,” “cyclobenzaprine,” “desipramine,” “desmethyldoxepin,” “dothiepin,” “doxepin,” “imipramine,” “iprindole,” “lofepramine,” “metapramine,” “mirtazapine,” “nortriptyline,” “opipramol,” “protriptyline,” “tianeptine,” “trimipramine.” These resulting articles were then reviewed to identify those that met the following inclusion criteria: 1) patients with subjective tinnitus of ≥6-month duration between the ages of 18 and 70, 2) treatment with antidepressant agents versus placebo, 3) outcomes measured in terms of validated scales, and 4) randomized controlled trials.

Keywords

Randomized Control Trial Auditory Brainstem Response Intravenous Lidocaine Multidimensional Pain Inventory Lidocaine Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bayar N, Boke B, Turan E, Belgin E. Efficacy of amitriptyline in the treatment of subjective tinnitus. J Otolaryngol 2001;30(5):300–303.CrossRefPubMedGoogle Scholar
  2. 2.
    Sullivan M, Katon W, Russo J, Dobie R, Sakai C. A randomized trial of nortriptyline for severe chronic tinnitus. Arch Intern Med 1993;153(19):2251–2259.CrossRefPubMedGoogle Scholar
  3. 3.
    Mihail M, Crowley JM, Walden BE, Fishburne J, Reinwall JF, Zajtchuk JT. The tricyclic trimipramine in the treatment of subjective tinnitus. Ann Otol Rhinol Laryngol 1988;97(2 Pt 1):120–123.PubMedGoogle Scholar
  4. 4.
    Dobie RA, Sakai CS, Sullivan MD, Katon WJ, Russo J. Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. Am J Otol 1993;14(1):18–23.PubMedGoogle Scholar

References

  1. 1.
    Simpson JA, Gilbert AM, Weiner GM, Davies WE. The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. J Laryngol Otol 1999;20:627–631.Google Scholar
  2. 2.
    Melding PS, Goodey RJ. The treatment of tinnitus with oral anticonvulsants. J Laryngol Otol 1979;93:111–122.CrossRefPubMedGoogle Scholar
  3. 3.
    Gananca MM, Caovilla HH, Gananca FF, et al. Clonazepam in the pharmacological treatment of vertigo and tinnitus. Int Tinnitus J 2002;8(1):50–53.PubMedGoogle Scholar

References

  1. 1.
    Berry JA, Gold SL, Frederick EA, Gray WC, Staecker H. Patient-based outcomes in patients with primary tinnitus undergoing tinnitus retraining therapy. Arch Otolaryngol Head Neck Surg 2002;128(10):1153–1157.PubMedGoogle Scholar
  2. 2.
    Dineen R, Doyle J, Bench J, Perry A. The influence of training on tinnitus perception: an evaluation 12 months after tinnitus management training. Br J Audiol 1999;33(1):29–51.PubMedGoogle Scholar
  3. 3.
    Folmer RL. Long-term reductions in tinnitus severity. BMC Ear Nose Throat Disord 2002;2(1):3.CrossRefPubMedGoogle Scholar
  4. 4.
    Jastreboff PJ, Gray WC, Gold SL. Neurophysiological approach to tinnitus patients. Am J Otol 1996;17(2):236–240.PubMedGoogle Scholar

References

  1. 1.
    Martin FW, Colman BH. Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine. Clin Otolaryngol Allied Sci, 1980;5(1):3–11.CrossRefPubMedGoogle Scholar
  2. 2.
    Majumdar B, Mason SM, Gibbin KP. An electrocochleographic study of the effects of lignocaine on patients with tinnitus. Clin Otolaryngol Allied Sci 1983;8(3):175–180.CrossRefPubMedGoogle Scholar
  3. 3.
    Israel JM, Connelly JS, McTigue ST, Brumme RE, Brown J. Lidocaine in the treatment of tinnitus aurium. A double-blind study. Arch Otolaryngol 1982;108(8):471–473.PubMedGoogle Scholar
  4. 4.
    Hulshof JH, Vermeij P. The effect of intravenous lidocaine and several different doses of oral tocainide HC1 on tinnitus. A dose-finding study. Acta Otolaryngol 1984;98(3–4):231–238.CrossRefPubMedGoogle Scholar
  5. 5.
    Duckert LG, Rees TS. Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial. Otolaryngol Head Neck Surg 1983;91(5):550–555.PubMedGoogle Scholar
  6. 6.
    Baguley DM, Jones S, Wilkins I, Axon PR, Moffat DA. The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, cross-over study. Otol Neurotol 2005;26(2):169–176.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Josh Finnell
    • 1
  • Jay F. Piccirillo
    • 2
  • Carol Bauer
    • 3
  • Thomas J. Brozoski
    • 4
  • Alison Perring
    • 5
  1. 1.Department of OtolaryngologyBarnes-Jewish HospitalSt. LouisUSA
  2. 2.Department of OtolaryngologyWashington University School of MedicineSt. LouisUSA
  3. 3.Division of Otolaryngology-Head and Neck SurgerySouthern Illinois University School of MedicineSpringfieldUSA
  4. 4.SurgerySouthern Illinois School of MedicineSpringfieldUSA
  5. 5.Southern Illinois University School of MedicineCarbondaleUSA

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