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From Cellular Electrophysiology to Electrocardiography

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Book cover Modeling and Imaging of Bioelectrical Activity

Part of the book series: Bioelectric Engineering ((BEEG))

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Abstract

Since many cardiac pathologies manifest themselves at the cellular and molecular levels, extrapolation to clinical variables, such as the electrocardiogram (ECG), would prove invaluable to diagnosis and treatment. One ultimate goal of the cardiac modeler is to integrate cellular level detail with quantitative properties of the ECG (a property of the whole heart). This magnificent task is not unlike a forest ranger attempting to document each leaf in a massive forest. Both the modeler and ranger need to place fundamental elements in the context of a broader landscape. But now, with the recent genome explosion, the modeler needs to examine the “leaves” at even much greater molecular detail. Fortunately, the rapid explosion in computational power allows the modeler to span the details of each molecular “leaf” to the “forest” of the whole heart. Thus, cardiac modeling is beginning to span the spectrum from DNA to the ECG, from nucleotide to bedside.

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  1. Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Ave., Baltimore, MD, 21205

    Nitish V. Thakor, Vivek Iyer & Mahesh B. Shenai

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  1. Nitish V. Thakor
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  2. Vivek Iyer
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  3. Mahesh B. Shenai
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  1. University of Minnesota, Minneapolis, Minnesota

    Bin He

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Thakor, N.V., Iyer, V., Shenai, M.B. (2004). From Cellular Electrophysiology to Electrocardiography. In: He, B. (eds) Modeling and Imaging of Bioelectrical Activity. Bioelectric Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-49963-5_1

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