From Cellular Electrophysiology to Electrocardiography

  • Nitish V. Thakor
  • Vivek Iyer
  • Mahesh B. Shenai
Part of the Bioelectric Engineering book series (BEEG)


Since many cardiac pathologies manifest themselves at the cellular and molecular levels, extrapolation to clinical variables, such as the electrocardiogram (ECG), would prove invaluable to diagnosis and treatment. One ultimate goal of the cardiac modeler is to integrate cellular level detail with quantitative properties of the ECG (a property of the whole heart). This magnificent task is not unlike a forest ranger attempting to document each leaf in a massive forest. Both the modeler and ranger need to place fundamental elements in the context of a broader landscape. But now, with the recent genome explosion, the modeler needs to examine the “leaves” at even much greater molecular detail. Fortunately, the rapid explosion in computational power allows the modeler to span the details of each molecular “leaf” to the “forest” of the whole heart. Thus, cardiac modeling is beginning to span the spectrum from DNA to the ECG, from nucleotide to bedside.


Spiral Wave Heart Model Color Figure Outward Potassium Current Coupling Resistance 
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© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Nitish V. Thakor
    • 1
  • Vivek Iyer
    • 1
  • Mahesh B. Shenai
    • 1
  1. 1.Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimore

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