Case Study: Mycophenolate Mofetil
Mycophenolate mofetil (MMF) is an orally bioavailable prodrug of mycophenolic acid (MPA), a potent immunosuppressive agent. MPA acts by inhibiting inosine monophosphate dehydrogenase (IMPDH), which catalyzes the first step in de novo synthesis of guanine (Ransom, 1995). This process is critical to mitogen-stimulating lymphocytes, which gives rise to MPA’s therapeutic efficacy.
KeywordsMycophenolate Mofetil Mycophenolic Acid Glucuronide Conjugate Amino Ester Inosine Monophosphate Dehydrogenase
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