Prodrugs pp 1299-1304 | Cite as

Case Study: Mycophenolate Mofetil

  • William A. Marinaro
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume V)


Mycophenolate mofetil (MMF) is an orally bioavailable prodrug of mycophenolic acid (MPA), a potent immunosuppressive agent. MPA acts by inhibiting inosine monophosphate dehydrogenase (IMPDH), which catalyzes the first step in de novo synthesis of guanine (Ransom, 1995). This process is critical to mitogen-stimulating lymphocytes, which gives rise to MPA’s therapeutic efficacy.


Mycophenolate Mofetil Mycophenolic Acid Glucuronide Conjugate Amino Ester Inosine Monophosphate Dehydrogenase 
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  1. Birkinshaw JH, Raistrick H, and Ross DJ. Studies in the Biochemistry of Microorganisms 86. The Molecular Constitution of Mycophenolic Acid, A Metabolic Product of Penicillium Brevi-Compactum Dierckx. Part 3. Further Observations on the Structural Formula for Mycophenolic Acid. Biochem J 1952; 50:630–634PubMedGoogle Scholar
  2. Conaway CC, Tong C, and Williams GM. Evaluation of Morpholine, 3-Morpholinone, and N-Substituted Morpholines in the Rat Hepatocyte Primary Culture/DNA Repair Test. Mutat Res 1984; 136:153–157PubMedCrossRefGoogle Scholar
  3. Epinette WW, Parker CM, Jones EL, and Griest MC. Mycophenolic Acid for Psoriasis, A Review of Pharmacology, Long-Term Efficacy, and Safety. J Am Acad Dermatol 1987; 17:962–971PubMedCrossRefGoogle Scholar
  4. Fulton B and Markham A. Mycophenolate Mofetil: A Review of its Pharmacodynamic and Pharmacokinetic Properties and Clinical Efficacy in Renal Transplantation. Drugs 1996; 51: 278–298PubMedCrossRefGoogle Scholar
  5. Gosio B. Ricerche Batteriologiche e Chimiche Sulle Alterazoni del Mais. Riv Ig Pubblica 1896; 7:825–868Google Scholar
  6. Hood KA and Zarembski DG. Mycophenolate Mofetil: A Unique Immunosuppressive Agent. Am J Health-Syst Pharm 1997; 54:285–294PubMedGoogle Scholar
  7. Jones EL, Epinette WW, Hackney VC, Menendez L, and Frost P. Treatment of Psoriasis with Oral Mycophenolic Acid. J Invest Dermatol 1975; 65:537–542PubMedCrossRefGoogle Scholar
  8. Lee WA, Gu L, Miksztal AR, Chu N, Leung K, and Nelson PH. Bioavailability Improvement of Mycophenolic Acid Through Amino Ester Derivatization. Pharm Res 1990; 7:161–166PubMedCrossRefGoogle Scholar
  9. Marinari R, Fleischmajer R, Schragger AH, and Rosenthal AL. Mycophenolic Acid in the Treatment of Psoriasis. Arch Dermatol 1977; 113:930–932PubMedCrossRefGoogle Scholar
  10. Nelson PH, Gu CLL, Allison AC, Eugui EM, and Lee WA. Heterocyclic Aminoalkyl Esters of Mycophenolic Acid, Derivatives Thereof and Pharmaceutical Compositions. US Patent #4,727,069 (February 23) 1988Google Scholar
  11. Ransom JT. Mechanism of Action of Mycophenolate Mofetil. Ther Drug Monit 1995; 17:681–684PubMedCrossRefGoogle Scholar
  12. Roche Laboratories. CellCept® Complete Product Information. 2003Google Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2007

Authors and Affiliations

  • William A. Marinaro
    • 1
  1. 1.Department of Pharmaceutical ChemistryThe University of KansasLawrenceUSA

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