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Prodrug approaches to ophthalmic drug delivery

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Book cover Prodrugs

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume V))

Abstract

Ophthalmic medications are administered either systematically or locally to the eye. In order to treat ocular disorders, the topical delivery of eye drops into the lower cul-de-sac of the eye is preferred since the drug effects are localized and less drug enters into the systemic circulation (i.e., systemic side effects are minimized). In addition, adequate ocular drug concentrations may be difficult to achieve with systemic administration, as the blood-ocular barrier effectively restricts the access of drugs from systemic circulation into intra-ocular targets.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Kuopio, Finland

    Tomi Järvinen & Riku Niemi

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  1. Tomi Järvinen
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  1. University of Kansas, Lawrence, KS, USA

    Valentino J. Stella  & Ronald T. Borchardt  & 

  2. Bristol-Myers Squibb Company, Princeton, NJ, USA

    Michael J. Hageman

  3. Gilead Sciences, Foster City, CA, USA

    Reza Oliyai

  4. Roche Palo Alto, LLC, Palo Alto, CA, USA

    Hans Maag

  5. Hoffmann-La Roche, Inc., Nutley, NJ, USA

    Jefferson W. Tilley

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© 2007 American Association of Pharmaceutical Scientists

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Järvinen, T., Niemi, R. (2007). Prodrug approaches to ophthalmic drug delivery. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_4

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