Targeting - Theoretical and Computational Models
Prodrugs are pharmacologically inactive compounds that undergo an in vivo chemical or enzymatic conversion to an active drug molecule to produce a therapeutic effect. An emerging application for prodrug technologies is their use for targeting drugs to specific tissues or cell types. The focus of this chapter is to review the potential use of prodrug technologies in achieving site-specific targeted delivery of drugs and to use computational models to illustrate conditions under which the targeted delivery can be achieved.
KeywordsTarget Site Central Volume Drug Permeability Drug Input Target Delivery System
Unable to display preview. Download preview PDF.
- Box GEP. Robustness in the Strategy of Scientific Model Building. In: Launer RL and Wilkinson GN. Robustness in Statistics. New York, NY. Academic Press; 1979:201–236Google Scholar
- Han HK and Amidon GL. Targeted Prodrug Design to Optimize Drug Delivery. AAPS PharmSci 2000; 2(1) article 6Google Scholar
- Stella VJ and Himmelstein KJ. Critique of Prodrugs and Site-Specific Drug Delivery. In: Bundgaard H, Hansen AB and Kofod, H. Optimization of Drug Delivery. Munksgaard, Copenhagen; 1982:134–155Google Scholar
- Stella VJ and Himmelstein KJ. Prodrugs: A Chemical Approach to Targeted Drug Delivery. In: Borchardt RT, Repta AJ, and Stella VJ. Directed Drug Delivery. Clifton, NJ: Humana Press; 1985a:247–267Google Scholar
- Stella VJ and Himmelstein KJ. Site-Specific Drug Delivery via Prodrugs. In: Bundgaard H. Design of Prodrugs. Amsterdam: Elsevier Science Publishers BV; 1985b:177–198Google Scholar