Abstract
Prodrugs are familiar entities to readers of this volume, while proenzymes are a group of naturally occurring proteins that are of increasingly recognized biological significance (Saklatvala et al., 2003). There is a structural resemblance between prodrugs and proenzymes, as Figure 1 illustrates. Both consist of two linked structural units. One of these units will eventually become the active drug in the case of prodrugs, or the active (mature) enzyme in the case of proenzymes. The other unit changes the properties of its partner unit while the two units remain linked.
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References
Boatright KM, Salvesen GS. Caspase Activation. In: Saklatvala J, Nagase H, and Salvesen G, Eds. Proteases and the Regulation of Biological Processes. London: Portland Press; 2003: 233–242
Bode W. Structural Basis of Matrix Metalloproteinase Function. In: Saklatvala J, Nagase H, and Salvesen G, Eds. Proteases and the Regulation of Biological Processes. London: Portland Press; 2003: 1–14
Brocklehurst K, Watts AB, Patel M, Verma C, Thomas, EW. Cysteine Proteases. In: Sinnott M, Ed. Comprehensive Biological Catalysis. London: Academic Press; 1998: vol. I, 381–423
Bryan PN. Prodomains and Protein Folding Catalysis. Chem. Rev. 2002; 102:4805–4815
Dunn BM. Structure and Mechanism of the Pepsin-Like Family of Aspartic Proteases. Chem. Rev. 2002; 102:4431–4458
Fersht A. Structure and Mechanism in Protein Science. New York: WH Freeman and Co.; 1998: 630p
Hedstrom L. Serine Protease Mechanism and Specificity. Chem. Rev. 2002; 102:4501–4524
Jackson CM, Nemerson Y. Blood Coagulation. Annu. Rev. Biochem. 1980; 49:765–811
Markwardt F. Acyl-enzymes as Prodrugs. Pharmazie 1989; 44:520–526
Oliyai R. Prodrugs of Peptides and Peptidomimetics for Improved Formulation and Delivery. Adv. Drug Deliv. Rev. 1996; 19:275–286
Saklatvala J, Nagase H, and Salvesen G, Eds. Proteases and the Regulation of Biological Processes. London: Portland Press; 2003. 292p
Smith RAG, Dupe RJ, English PD, Green J. Fibrinolysis with Acyl-enzymes: a New Approach to Thrombolytic Therapy. Nature 1981; 290: 505–508
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© 2007 American Association of Pharmaceutical Scientists
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Schowen, R.L. (2007). Controlled Release - Proenzymes. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_11
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DOI: https://doi.org/10.1007/978-0-387-49785-3_11
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