Mapping Qualitative Traits in Humans Using Affected Sib Pairs

Part of the Statistics for Biology and Health book series (SBH)


In humans we cannot create inbred lines, backcrosses, etc. Consequently, it is more difficult to study directly the correlation of phenotypes and genetic markers. We can proceed indirectly by noting that relatives frequently have more similar phenotypes than non-relatives, presumably because they have more similar genotypes. For studying human diseases, particularly convenient units are affected sib pairs (ASP), which are the subject of this chapter. We delay until Chap. 11 a discussion of the substantially more complex problem of pedigrees involving variable numbers and relationships of affecteds.


Hide Markov Model Conditional Distribution Null Distribution Disease Allele Noncentrality Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science + Business Media, LLC 2007

Personalised recommendations