Fundamentals of Genetics: Inbreeding, Recombination, Random Mating, and Identity by Descent
This chapter introduces some concepts of population genetics that are used in various places later in the book. In addition it allows us to expand our knowledge of R functions and to practice conditional probability arguments, which are used here to analyze the genetic makeup of the present generation by conditioning on that of the parental generation. The reader who has a working knowledge of R may wish to skip Sect. 3.1 and the latter part of Sect. 3.2 that refers to Sect. 3.1. The first part of Sect. 3.2 (including the programs “meiosis.rec” and “cross.rec”) introduces the concept of recombination, which plays a very important role throughout the book. It can be read independently of Sect. 3.1. Sections 3.3 and 3.4 are important for the third part of the book that deals with human genetics. This chapter contains some relatively difficult mathematical material, which is marked by an asterisk (*) and can be omitted.
KeywordsRandom Mating Inbred Strain Recombination Fraction Linkage Equilibrium Paternal Allele
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