Hemodynamic Effects of Activated Protein C in Septic Shock

  • N. Sennoun
  • O. Desebbe
  • B. Levy
Conference paper


Recombinant human activated protein C (rhAPC) has been demonstrated to reduce the mortality rate of adult patients with severe sepsis [1]. This effect is thought to be related to a reduction in coagulation and, to a lesser extent, to a reduction in the inflammatory response to sepsis. Data from the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study demonstrated that the use of rhAPC was associated with a quicker reduction in cardiovascular failure.


Septic Shock Severe Sepsis Mean Arterial Pressure Migration Inhibitory Factor Simplify Acute Physiology Score 
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Copyright information

© Springer Science + Business Media Inc. 2007

Authors and Affiliations

  • N. Sennoun
    • 1
  • O. Desebbe
    • 1
  • B. Levy
    • 1
  1. 1.Mecical Intensive Care UnitHôpital de BraboisVandoeuvre les NancyFrance

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