Abstract
Recombinant human activated protein C (rhAPC) has been demonstrated to reduce the mortality rate of adult patients with severe sepsis [1]. This effect is thought to be related to a reduction in coagulation and, to a lesser extent, to a reduction in the inflammatory response to sepsis. Data from the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study demonstrated that the use of rhAPC was associated with a quicker reduction in cardiovascular failure.
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Sennoun, N., Desebbe, O., Levy, B. (2007). Hemodynamic Effects of Activated Protein C in Septic Shock. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_8
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DOI: https://doi.org/10.1007/978-0-387-49518-7_8
Publisher Name: Springer, New York, NY
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