Oral Anticoagulant Overdose and Bleeding Risk

  • C. J. Wiedermann


The major complication associated with the use of warfarin is bleeding due to excess anticoagulation. The risk of major bleeding episodes in patients treated with warfarin is related to the degree of anticoagulation. An exception to this general rule is retroperitoneal hemorrhage, which may be more common in patients taking anticoagulants, even when levels are within the therapeutic range [1]. Intracranial hemorrhage (ICH) is the most serious and lethal complication of antithrombotic therapy. Over one-half of patients with warfarin-associated ICH die within the first 3 months, a substantially higher mortality rate than that of spontaneous ICH in those not receiving anticoagulants [2, 3].


International Normalize Ratio Prothrombin Complex Concentrate Oral Anticoagulant Therapy Oral Vitamin International Normalize Ratio Range 


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Copyright information

© Springer Science + Business Media Inc. 2007

Authors and Affiliations

  • C. J. Wiedermann
    • 1
  1. 1.Division of Internal Medicine 2 Department of MedicineCentral HospitalBolzanoItaly

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