Abstract
Acute brain injury is a frequent cause of disability and death worldwide. Common forms of acute brain injury include perinatal birth asphyxia, traumatic brain injury (TBI), stroke, and out-of-hospital cardiac arrest. These conditions affect patients with a wide age range from the young to the elderly. Interruption of cerebral oxygen and nutrient delivery by cardio-respiratory insufficiency or by a vascular lesion may precipitate cerebral ischemia. The initial pathology may not induce immediate cell death, but can precipitate a complex biochemical cascade leading to delayed neuronal loss, the end result being death or disability (Fig. 1). This chapter reviews the current evidence on temperature reduction after neuronal injury.
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Andrews, P.J.D., Anderson, E.L., Saxena, M. (2007). Cooling Therapies after Neuronal Injury: Direct Brain Cooling and Systemic Hypothermia. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_63
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DOI: https://doi.org/10.1007/978-0-387-49518-7_63
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