Cooling Therapies after Neuronal Injury: Direct Brain Cooling and Systemic Hypothermia

  • P. J. D. Andrews
  • E. L. Anderson
  • M. Saxena


Acute brain injury is a frequent cause of disability and death worldwide. Common forms of acute brain injury include perinatal birth asphyxia, traumatic brain injury (TBI), stroke, and out-of-hospital cardiac arrest. These conditions affect patients with a wide age range from the young to the elderly. Interruption of cerebral oxygen and nutrient delivery by cardio-respiratory insufficiency or by a vascular lesion may precipitate cerebral ischemia. The initial pathology may not induce immediate cell death, but can precipitate a complex biochemical cascade leading to delayed neuronal loss, the end result being death or disability (Fig. 1). This chapter reviews the current evidence on temperature reduction after neuronal injury.


Traumatic Brain Injury Acute Ischemic Stroke Neuronal Injury Therapeutic Hypothermia Brain Temperature 
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Copyright information

© Springer Science + Business Media Inc. 2007

Authors and Affiliations

  • P. J. D. Andrews
    • 1
  • E. L. Anderson
    • 1
  • M. Saxena
    • 1
  1. 1.Department of Anesthesia, Intensive Care and Pain ManagementWestern General HospitalEdinburghUK

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