Abstract
Acute liver failure is a syndrome manifest by the rapid cessation of hepatic function in previously normal individuals. The rate of decline in function dictates the manner in which the syndrome manifests and influences the outcome. The etiology of the insult to the liver is the main influence on the rate of progression and the likelihood of spontaneous recovery [1].
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References
O’Grady JG, Schalm SW, Williams R (1993) Acute liver failure: redefining the syndromes. Lancet 342:273–275
Bernal W (2003) Changing patterns of causation and the use of transplantation in the United kingdom. Semin Liver Dis 23:227–237
Lee WM (2003) Acute liver failure in the United States. Semin Liver Dis 23:217–226
Lucke B, Mallory t (1946) Fulminant form of epidemic hepatitis. Am J Pathol 22:867–945
Ware AJ, D’Agostino AN, Combes B (1971) Cerebral edema: a major complication of massive hepatic necrosis. Gastroenterology 61:877–884
Hanid MA, Mackenzie RL, Jenner RE, et al (1979) Intracranial pressure in pigs with surgically induced acute liver failure. Gastroenterology 76:123–131
Wendon JA, Larsen FS (2006) Intracranial pressure monitoring in acute liver failure. A proce dure with clear indications. Hepatology 44:504–506
Jacques Bernuau, Durand F (2006) Intracranial pressure monitoring in patients with acute liver failure: A questionable invasive surveillance. Hepatology 44:502–504
Blei AT (2005) The pathophysiology of brain edema in acute liver failure. Neurochem Int 47: 71–77
Norenberg MD, Rao KV, Jayakumar AR (2005) Mechanisms of ammonia-induced astrocyte swelling. Metab Brain Dis 20:303–318
Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P (1999) Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29:648–653
Bhatia V, Singh R, Acharya SK (2005) Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 55:98–104
Traber PG, Dal Canto M, Ganger DR, Blei AT (1987) Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier. Hepatology 7:1272–1277
Kato M, Hughes RD, Keays RT, Williams R (1992) Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure. Hepatology 15:1060–1066
Takahashi H, Koehler RC, Brusilow SW, Traystman RJ (1991) Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats. Am J Physiol 261:H825–829
Cordoba J, Gottstein J, Blei AT (1996) Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. Hepatology 24:919–923
Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF (2003) Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic reso nance study. Hepatology 37:420–428
Jayakumar AR, Rao KV, Murthy ChR, Norenberg MD (2006) Glutamine in the mechanism of ammonia-induced astrocyte swelling. Neurochem Int 48:623–628
Tofteng F, Jorgensen L, Hansen BA, Ott P, Kondrup J, Larsen FS (2002) Cerebral microdialysis in patients with fulminant hepatic failure. Hepatology 36:1333–1340
Wendon JA, Harrison PM, Keays R, Williams R (1994) Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 19:1407–1413
Blei AT, Larsen FS (1999) Pathophysiology of cerebral edema in fulminant hepatic failure. J Hepatol 31:771–776
Larsen FS, Adel Hansen B, Pott F (1996) Dissociated cerebral vasoparalysis in acute liver failure. A hypothesis of gradual cerebral hyperaemia. J Hepatol 25:145–151
Aggarwal S, Obrist W, Yonas H, et al (2005) Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. Liver Transpl 11:1353–1360
Shawcross DL, Davies NA, Mookerjee RP (2004) Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy. Hepatology 39:471–475
Strauss G, Hansen BA, Kirkegaard P, Rasmussen A, Hjortrap A, Larsen FS (1997) Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure. Hepatology 25:837–839
Tofteng F, Larsen FS (2004) The effect of indomethacin on intracranial pressure, cerebral per fusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 24:798–804
Tofteng F, Larsen FS (2004) Management of patients with fulminant hepatic failure and brain edema. Metab Brain Dis 19:207–214
Bernal W, Wendon J (2004) Intracranial hypertension in acute liver failure; prevalence and risk factors for development. Hepatology 40:162A–266A
Boeckx NK, Haydon G, Rusli F, Murphy N (2004) Multiorgan failure is the commonest cause of death in fulminant hepatic failure: a single centre experience. Liver Int 24:702–703
Jalan R (2003) Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis 23:271–282
Makin AJ, Wendon J, Williams R (1995) A 7-year experience of severe acetominophen-induced hepatotoxicity (1987–1993). Gastroenterology 109:1907–1916
Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS (2006) Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 26:21–27
Wijdicks EF, Plevak DJ, Rakela J, Wiesner RH (1995) Clinical and radiologic features of cerebral edema in fulminant hepatic failure. Mayo Clin Proc 70:119–124
Munoz SJ, Robinson M, Northrup B, et al (1991) Elevated intracranial pressure and computed tomography of the brain in fulminant hepatocellular failure. Hepatology 13:209–212
Strauss G I, Hogh P, Knudsen GM, Hansen BA, Larsen FS (1999) Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology 30:1368–1373
Ranjan P, Mishra AM, Kale R, Saraswat VA, Gupta RK (2005) Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure: in vivo demonstration using diffusion-weighted MRI in human subjects. Metab Brain Dis 20:181–192
Nortje J, Gupta AK (2006) The role of tissue oxygen monitoring in patients with acute brain injury. Br J Anaesth 97:95–106
Ellis AJ, Wendon JA, Williams R (2000) Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: a controlled clinical trial. Hepatology 32:536–541
Nielsen HB, Tofteng F, Wang LP, Larsen FS (2003) Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure. J Hepatol 38: 188–192
Strauss GI, Moller K, Holm S, Sperling B, Knudsen GM, Larsen FS (2001) Transcranial Dopplersonography and internal jugular bulb saturation during hyperventilation in patients with fulminant hepatic failure. Liver Transpl 7:352–358
Blei AT, Olafsson S, Webster S, Levy R (1993) Complications of intracranial pressure monitoring in fulminant hepatic failure. Lancet 341:157–158
The Brain Trauma Foundation, The American Association of Neurological Surgeons, The Joint Section on Neurotrauma and Critical Care (2000). Indications for intracranial pressure monitoring. J Neurotrauma 17:479–491
Vaquero J, Fontana RJ, Larson AM, et al (2005) Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl 11:1581–1589
Shami VM, Caldwell SH, Hespenheide EE, Arseneau KO, Bickston SJ, Macik BG (2003) Recombinant activated factor VII for coagulopathy in fulminant hepatic failure compared with conventional therapy. Liver Transpl 9:138–143
Keays RT, Alexander GL, Williams R (1993) The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure. J Hepatol 18:205–209
Tandon BN, Joshi YK, Tandon M (1986) Acute liver failure. Experience with 145 patients. J Clin Gastroenterol 8:664–668
Murphy N, Auzinger G, Bernel W, Wendon J (2004) The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure. Hepatology 39:464–470
Murphy ND, Wendon J (1999) Serum sodium is inversely proportional to intracranial pres sure in acute liver failure. Crit Care 3(Supp 1):P220 (abst)
The Brain Trauma Foundation, The American Association of Neurological Surgeons, The Joint Section on Neurotrauma and Critical Care (2000) Guidelines for cerebral perfusion pressure. J Neurotrauma 17:507–511
Tofteng F, Larsen FS (2004) Management of patients with fulminant hepatic failure and brain edema. Metab Brain Dis 19:207–214
Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A (2001) Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypo thermia. Hepatology 34:50–54
Davis MH, Multimer D, Lowes J, Elias E, Neuberger J (1994) Recovery despite impaired cerebral perfusion in fulminant hepatic failure. Lancet 343:1329–1330
Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A (2004) Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology 127:1338–1346
Wijdicks EF, Nyberg SL (2002) Propofol to control intracranial pressure in fulminant hepatic failure. Transplant Proc 34:1220–1222
Strauss GI, Moller K, Larsen FS, Kondrup J, Knudsen GM (2003) Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure. Liver Transpl 9: 1244–1252
The Brain Trauma Foundation, The American Association of Neurological Surgeons, The Joint Section on Neurotrauma and Critical Care (2000) Intracranial pressure treatment threshold. J Neurotrauma 17:493–495
Canalese J, Gimson AE, Davis C, Mellon PJ, Davis W, Williams R (1982) Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure. Gut 23:625–629
Ede RJ, Gimson AE, Bihari D, Williams R (1986) Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure. J Hepatol 2:43–51
Bhatia V, Batra Y, Acharya SK (2004) Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure-a controlled clinical trial. J Hepatol 41:89–96
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Murphy, N. (2007). The Pathology and Management of Intracranial Hypertension in Acute Liver Failure. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_60
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DOI: https://doi.org/10.1007/978-0-387-49518-7_60
Publisher Name: Springer, New York, NY
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