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Transcription Factors and Nuclear Cofactors in Muscle Wasting

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Intensive Care Medicine

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Abstract

Muscle wasting is commonly seen in patients with sepsis, severe injury, and cancer [1, 2]. The loss of muscle mass in these conditions mainly reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins although other proteolytic mechanisms may be involved as well [3]. Muscle atrophy is regulated by multiple factors, including glucocorticoids [4], the pro-inflammatory cytokines, interleukin (IL)-1(3 and tumor necrosis factor (TNF)-α [5, 6], and myostatin [7]. In addition to these catabolic factors, a lack of anabolic signals, such as insulin-like growth factor (IGF)-1 and insulin, is probably also important for the development of muscle wasting in various catabolic conditions.

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Author information

Authors and Affiliations

  1. Department of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue ST919, Boston, MA, 02215, USA

    P. -O. Hasselgren

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  1. P. -O. Hasselgren
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2007 Springer Science + Business Media Inc.

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Hasselgren, P.O. (2007). Transcription Factors and Nuclear Cofactors in Muscle Wasting. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_21

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  • DOI: https://doi.org/10.1007/978-0-387-49518-7_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-49517-0

  • Online ISBN: 978-0-387-49518-7

  • eBook Packages: MedicineMedicine (R0)

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