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Are Mitochondria Responsible for Improved Outcomes in Recent Studies?

  • Conference paper
Intensive Care Medicine

Abstract

The Acute Respiratory Distress Syndrome Network (ARDSnet) group compared low tidal volume ventilation with standard ventilatory strategies [1]; early goal directed therapy (EGDT) advocated administering fluids, blood products, and dobutamine to achieve oxygen delivery goals to septic patients on arrival in the emergency department [2]; and intensive insulin therapy was used to maintain tight glucose parameters in surgical patients [3]. These are landmark but disparate trials that have demonstrated major improvements in outcome and feature in the Surviving Sepsis Campaign Guidelines for managing sepsis [4]. In this chapter, we discuss the role mito-chondrial dysfunction plays in critical illness and its manifestation as a disruption of cellular energetics. We suggest that the positive outcomes from the above-mentioned trials relate to a reduction of impaired mitochondrial function and a reduction in the subsequent generation of inflammatory signals.

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Author information

Authors and Affiliations

  1. Department of Respiratory and Intensive Care Medicine Royal Center for Defense Medicine and Department of Medicine, University Hospital, Birmingham, B15 2TT, UK

    A. Johnston

  2. Department of Intensive Care Medicine, University Hospital, Birmingham, B15 2TT, UK

    T. Whitehouse

Authors
  1. A. Johnston
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  2. T. Whitehouse
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2007 Springer Science + Business Media Inc.

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Johnston, A., Whitehouse, T. (2007). Are Mitochondria Responsible for Improved Outcomes in Recent Studies?. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_17

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  • DOI: https://doi.org/10.1007/978-0-387-49518-7_17

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-49517-0

  • Online ISBN: 978-0-387-49518-7

  • eBook Packages: MedicineMedicine (R0)

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