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The Role of Neutrophil-Derived Myeloperoxidase in Organ Dysfunction and Sepsis

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Book cover Intensive Care Medicine

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Abstract

Neutrophils are the first cells to be activated in the host immune response to infection or injury and are critical cellular effectors in both humoral and innate immunity, central to the pathogenesis of sepsis and multi-organ dysfunction [1]. However, the neutrophil capacity for bacterial killing lacks selectivity, despite stringent regulation, and thereby carries the potential to inflict collateral damage to, and destruction of host tissue [2]. Host tissue damage characterizes both autoimmune and inflammatory conditions and may arise via a variety of mechanisms including premature neutrophil activation during migration, extracellular release of cytotoxic molecules during microbial killing, removal of infected or damaged host cells or debris during host tissue remodeling, and failure to terminate acute inflammatory responses [3]. Sepsis-induced neutrophil mediated tissue injury has been demonstrated in a variety of organs including the lungs [4, 5], kidneys [6], and liver [7].

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Author information

Authors and Affiliations

  1. Department of Critical Care, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    N. S. MacCallum, G. J. Quinlan & T. W. Evans

Authors
  1. N. S. MacCallum
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  2. G. J. Quinlan
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  3. T. W. Evans
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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MacCallum, N.S., Quinlan, G.J., Evans, T.W. (2007). The Role of Neutrophil-Derived Myeloperoxidase in Organ Dysfunction and Sepsis. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49518-7_16

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  • DOI: https://doi.org/10.1007/978-0-387-49518-7_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-49517-0

  • Online ISBN: 978-0-387-49518-7

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