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PET-CT Imaging in Multiple Myeloma, Solitary Plasmacytoma, and Related Plasma Cell Dyscrasias

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Clinical PET-CT in Radiology

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Abstract

In multiple myeloma and related plasma cell dyscrasias, either FDG PET or PET-CT imaging is useful and reliable technique for diagnosis by identifying optimal sites for biopsy, for staging and restaging the tumor, for detecting extramedullary disease and monitoring response to treatment, though PET-CT is superior for precise localization of regions of involvement, discrimination between infection and tumor, and detection of important additional findings, such as epidural disease, spinal cord compression, lytic bone disease (including areas at risk for fracture), etc. FDG PET and PET-CT are equally effective in either secretory or nonsecretory disease, with the latter developing with an increasing frequency during the course of the disease, causing difficulty in monitoring disease response or progression via laboratory means. FDG PET or PET-CT imaging is also useful techniques for detecting occult infection in patients with hematologic malignancies, for finding the source of infection and documenting response to treatment of infection, even in the setting of severe neutropenia/immunosuppression.

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References

  1. Barlogie B, Shaughnessy J, Epstein J, Sanderson R, Anaissie R, Walker R, Tricot G. Plasma cell myeloma. Williams’ Hematology, 7th edn. New York: McGraw-Hill, 2005.

    Google Scholar 

  2. Shaughnessy J, Barlogie B. Interpreting the molecular biology and clinical behavior of MM in the context of global gene expression profiling. Immunol Rev 2003;194:140–163.

    Article  CAS  PubMed  Google Scholar 

  3. Angtuaco EJC, Fassas AB, Walker RC, et al. Multiple myeloma: clinical review and diagnostic imaging. Radiology 2004;231:11–23.

    Article  PubMed  Google Scholar 

  4. Durie B, Kyle R, Belch A, et al. Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation. Hematol J 2003;4:379–398.

    Article  PubMed  Google Scholar 

  5. Walker R, Jones-Jackson L, Miceli M, et al. FDG PET functional imaging in multiple myeloma clinically important caveats, pitfalls, and pearls. Blood 2004;104:11.

    Article  Google Scholar 

  6. Walker R, Jones-Jackson L, Rasmussen E, et al. Rapid response to treatment of multiple myeloma detected with FDG PET scanning in multiple myeloma—early results from total therapy III. Blood 2004;104:11.

    Article  Google Scholar 

  7. Walker R, Jones-Jackson L, Rasmussen E, et al. Diagnostic imaging of multiple myeloma—FDG PET and MRI complementary for tracking short vs. long term tumor response. Blood 2004;104(11):217a.

    Google Scholar 

  8. Walker R, Jones-Jackson L, Rasmussen E, et al. MRI-detectable focal lesions (FL) in multiple myeloma (MM) at relapse frequently involve novel sites not involved at diagnosis. Blood 2004;104(11):364b.

    Google Scholar 

  9. Orchard K, Barrington S, Buscombe et al. A. Fluoro-deoxyglucose positron emission tomography imaging for the detection of occult disease in MM. Br J Haematol 2002;117:133–135.

    Article  PubMed  Google Scholar 

  10. Schirrmeister H, Bommer M, Buck AK, et al. Initial results in assessment of MM using 18F-FDG PET. Eur J Nucl Med 2002;29:361–366.

    Article  CAS  Google Scholar 

  11. Durie B, Waxman A, D’Agnolo A, et al. Whole-body 18F-FDG PET identifies high-risk myeloma. J Nucl Med 2002;43:1457–1463.

    PubMed  Google Scholar 

  12. Durie BG, Salmon SE. A clinical staging system for MM: correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer 1975;36:842–854.

    Article  CAS  PubMed  Google Scholar 

  13. Barlogie B, Shaughnessy J, Tricot G, et al. Treatment of multiple myeloma. Blood 2004;103:20–32.

    Article  CAS  PubMed  Google Scholar 

  14. Walker RC, Jones-Jackson LB, Rasmussen E, et al. PET and PET-CT imaging in multiple myeloma, solitary plasmacytoma, MGUS and other plasma cell dyscrasias. In: Valk PE, Delbeke D, Bailey DL, et al. (eds.). Positron Emission Tomography Clinical Practice. London: Springer, 2006.

    Google Scholar 

  15. Roodman GD. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 2004;32:290–292.

    Article  CAS  PubMed  Google Scholar 

  16. Miceli MH, Atoui R, Walker R, et al. Diagnosis of deep septic thrombophlebitis in cancer patients by Fluorine-18 fluorodeoxyglucose positron emission tomography scanning: a preliminary report. J Clin Oncol 2004;22:1949–1956.

    Article  PubMed  Google Scholar 

  17. Miceli MH, Jones-Jackson LB, Walker RC, et al. Diagnosis of infection of implantable central venous catheters by Fluorine-18 fluorodeoxyglucose positron emission tomography Nucl Med Commun 2004;25:813–818.

    Article  PubMed  Google Scholar 

  18. Anaissie E, Miceli M, Stroud S, et al. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (pet): an important tool in the management of infection in patients with hematological cancer. Blood 2004;104:11.

    Article  Google Scholar 

  19. Walker RC. Personal communication, unpublished data. Little Rock, AR: University of Arkansas for Medical Sciences, 2005.

    Google Scholar 

  20. Avva R, Vanhemert R, Barlogie B, et al. CT-guided biopsy of focal lesions in patients with multiple myeloma may reveal new and more aggressive cytogenetic abnormalities. Am J Neuroradiol 2001;22(4):781–785.

    CAS  PubMed  Google Scholar 

  21. Kyle R, Child JA, Anderson K, et al. Criteria for the classification of monoclonal gammopathies, MM and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749–757.

    Article  Google Scholar 

  22. Migliorati CA. Bisphosphonates and oral cavity avascular bone necrosis. J Clin Oncol 2003;21:4253–4254.

    Article  PubMed  Google Scholar 

  23. O’Brien SN, Blijlevens NM, Mahfouz TH, et al. Infections in patients with hematological cancer: recent developments. Am Soc Hematol Educ Program 2003; 438–472.

    Google Scholar 

  24. Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer 2004;100:228–237.

    Article  PubMed  Google Scholar 

  25. Sugawara Y. Infection and inflammation. In: Wahl R, Buchanam J (eds.). Principles and Practice of Positron Emission Tomography, 1st edn. Philadelphia: Lippincott Williams & Wilkins, 2002:381–394.

    Google Scholar 

  26. Stumpe KD, Dazzi H, Schaffner A, et al. Infection imaging using whole-body FDG-PET. Eur J Nucl Med 2000;27:822–832.

    Article  CAS  PubMed  Google Scholar 

  27. Zhuang H, Alavi A. 18-Fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 2002;32:47–59.

    Article  PubMed  Google Scholar 

  28. Rennen H, Boerman O, Oyen W, et al. Imaging infection/inflammation in the new millennium. Eur J Nucl Med 2001;28:241–252.

    Article  CAS  PubMed  Google Scholar 

  29. De Winter F, Vogelaers D, Gemmel F, et al. Promising role of 18-F-fluoro-D-deoxyglucose positron emission tomography in clinical infectious diseases. Eur J Clin Microbiol Infect Dis 2002;21:247–257.

    Article  PubMed  Google Scholar 

  30. Gibel LJ, Hartshorne MF, Tzamaloukas AH. Indium-111 oxime leukocyte scan in the diagnosis of peritoneal catheter tunnel infections. Perit Dial Int 1998;18:234–235.

    CAS  PubMed  Google Scholar 

  31. Mettler F, Guiberteau M. Inflammation and infection imaging.In: Mettler F (ed.). Essentials of Nuclear Medicine Imaging, 4th edn. Philadelphia: Saunders, 1998:387–403.

    Google Scholar 

  32. van Rhee F, Alikhan M, Munshi N, et al. Anti-IL6 antibody (ab) based strategies improve the management of HIV negative castleman’s disease. Blood 2004;104:11.

    Article  Google Scholar 

  33. Volberding P, Baker K, Levine A. Human immunodeficiency virus hematology. Hematology 2003;294–313. (www.hematology.org).

  34. Brown J, Skarkin A. Clinical mimics of lymphoma. Oncologist 2004;9:406–416.

    Article  PubMed  Google Scholar 

  35. Ghobrial IM, Gertz MA, Fonseca R. Waldenström macroglobulinaemia. Lancet Oncol 2003;4:679–685.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Radiology & Radiological Sciences, Vanderbilt University Medical Center, 1121 21st Avenue South CCC-1121, Nashville, 37232-2675, TN, USA

    Ronald C. Walker

Authors
  1. Ronald C. Walker
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  2. Marisa H. Miceli
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  3. Laurie Jones-Jackson
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Correspondence to Ronald C. Walker .

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Editors and Affiliations

  1. Advanced Radiology Services, North Evergreen Drive 3264, Grand Rapids, 49525, Michigan, USA

    Paul Shreve

  2. , Head, PET and SPECT Development, Singapore Bioimaging Consortium, 11 Biopolis Way #02-02 Hel, Singapore, 138667, Singapur, Singapore

    David W. Townsend

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Walker, R.C., Miceli, M.H., Jones-Jackson, L. (2011). PET-CT Imaging in Multiple Myeloma, Solitary Plasmacytoma, and Related Plasma Cell Dyscrasias. In: Shreve, P., Townsend, D. (eds) Clinical PET-CT in Radiology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-48902-5_23

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  • DOI: https://doi.org/10.1007/978-0-387-48902-5_23

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  • Online ISBN: 978-0-387-48902-5

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