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Stress-induced Changes in Immune Cell Distribution and Trafficking: Implications for Immunoprotection versus Immunopathology

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Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

Abstract

Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery, wounding, infection, or vaccination. Immune cells circulate continuously on surveillance pathways that take them from the blood, through various organs, and back into the blood. This circulation is essential for the maintenance of an effective immune defense network (Sprent and Tough, 1994).The numbers and proportions of leukocytes in the blood provide an important representation of the state of distribution of leukocytes in the body and of the state of activation of the immune system. A stress-induced change in leukocyte distribution within different body compartments is perhaps one of the most underappreciated effects of stress and stress hormones on the immune system.

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References

  • Ackerman, K.D., Heyman, R., Rabin, B.S., Anderson, B.P., Houck, P.R., Frank, E., and Baum, A. (2002). Stressful life events precede exacerbations of multiple sclerosis. Psychosom. Med. 64:916–920.

    Article  PubMed  Google Scholar 

  • Al’Abadie, M.S., Kent, G.G., and Gawkrodger, D.J. (1994). The relationship between stress and the onset and exacerbation of psoriasis and other skin conditions. Br. J. Dermatol. 130:199–203.

    Article  PubMed  CAS  Google Scholar 

  • Amkraut, A.A., Solomon, C.F., and Kraemer, H.C. (1971). Stress, early experience and adjuvant-induced arthritis in the rat. Psychosom. Med. 33:203–214.

    PubMed  CAS  Google Scholar 

  • Bauer, M.E., Perks, P., Lightman, S.L., and Shanks, N. (2001). Are adhesion molecules involved in stress-induced changes in lymphocyte distribution? Life Sci. 69: 1167–1179.

    Article  PubMed  CAS  Google Scholar 

  • Baumann, H., Firestone, G.L., Burgess, T.L., Gross, K.W., Yamamoto, K.R., and Held, W.A. (1983). Dexamethasone regulation of a1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J. Biol. Chem. 258:563–570.

    PubMed  CAS  Google Scholar 

  • Benschop, R.J., Oostveen, F.G., Heijnen, C.J., and Ballieux, R.E. (1993). Beta 2-adrenergic stimulation causes detachment of natural killer cells from cultured endothelium. Eur. J. Immunol. 23:3242–3247.

    Article  PubMed  CAS  Google Scholar 

  • Benschop, R.J., Rodriguez-Feuerhahn, M., and Schedlowski, M. (1996). Catecholamine-induced leukocytosis: Early observations, current research, and future directions. Brain Behav. Immun. 10:77–91.

    Article  PubMed  CAS  Google Scholar 

  • Bilbo, S.D., Dhabhar, F.S., Viswanathan, K., Saul, A., Yellon, S.M., and Nelson, R.J. (2002). Short day lengths augment stress-induced leukocyte trafficking and stressinduced enhancement of skin immune function. Proc. Natl. Acad. Sci. U.S.A. 99: 4067–4072.

    Article  PubMed  CAS  Google Scholar 

  • Bosch, J.A., Berntson, G.G., Cacioppo, J.T, Dhabhar, F.S., and Marucha, P.T. (2003). Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: A potential pathway linking immunologic reactivity to cardiovascular disease. Brain Behav. Immun. 17:251–259.

    Article  PubMed  CAS  Google Scholar 

  • Brosschot, J.F., Benschop, R.J., Godaert, G.L., Olff, M., De Smet, M., Heijnen, C.J., and Ballieux, R.E. (1994). Influence of life stress on immunological reactivity to mild psychological stress. Psychosom. Med. 56:216–224.

    PubMed  CAS  Google Scholar 

  • Carlson, S.L., Fox, S., and Abell, K.M. (1997). Catecholamine modulation of lymphocyte homing to lymphoid tissues. Brain Behav. Immun. 11:307–320.

    Article  PubMed  CAS  Google Scholar 

  • Claman, H.N. (1972). Corticosteroids and lymphoid cells. N. Engl. J. Med. 287: 388–397.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, J.J. (1972). Thymus-derived lymphocytes sequestered in the bone marrow of hydrocortisone-treated mice. J. Immunol. 108:841–844.

    PubMed  CAS  Google Scholar 

  • Cohen, J.J. (1992). Glucocorticoid-induced apoptosis in the thymus. Semin. Immunol. 4:363–369.

    PubMed  CAS  Google Scholar 

  • Cox, J.H., and Ford, W.L. (1982). The migration of lymphocytes across specialized vascular endothelium. IV. Prednisolone acts at several points on the recirculation pathway of lymphocytes. Cell Immunol. 66:407–422.

    Article  PubMed  CAS  Google Scholar 

  • Cunnick, J.E., Lysle, D.T., Kucinski, B.J., and Rabin, B.S. (1990). Evidence that shockinduced immune suppression is mediated by adrenal hormones and peripheral beta-adrenergic receptors. Pharmacol. Biochem. Behav. 36:645–651.

    Article  PubMed  CAS  Google Scholar 

  • Danes, R.A., and Araneo, B.A. (1989). Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4. Eur. J. Immunol. 19:2319–2325.

    Article  Google Scholar 

  • Dhabhar, F.S. (1998). Stress-induced enhancement of cell-mediated immunity. In S.M. McCann, J.M. Lipton, E.M. Sternberg, G.P. Chrousos, P.W. Gold, and C.C. Smith (eds.), Neuroimmunomodulation: Molecular, Integrative Systems, and Clinical Advances. New York: New York Academy of Sciences, pp. 359–372.

    Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1996). Stress-induced enhancement of antigen-specific cell-mediated immunity. J. Immunol. 156:2608–2615.

    PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1997). Acute stress enhances while chronic stress suppresses immune function in vivo: A potential role for leukocyte trafficking. Brain Behav. Immun. 11:286–306.

    Article  PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1999a). Enhancing versus suppressive effects of stress hormones on skin immune function. Proc. Natl. Acad. Sci. U.S.A. 96: 1059–1064.

    Article  PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1999b). Changes in blood leukocyte distribution: interactions between catecholamine & glucocorticoid hormones. Neuroimmunomodulation. 6:213.

    Article  Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (2001). Bidirectional effects of stress & glucocorticoid hormones on immune function: Possible explanations for paradoxical observations. In R. Ader, D.L. Felten, and N. Cohen (eds.), psychoneuroimmunology, Third ed. San Diego: Academic Press, pp. 301–338.

    Google Scholar 

  • Dhabhar, F.S., and Viswanathan, K. (2005). Short-term stress experienced at the time of immunization induces a long-lasting increase in immunological memory. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289:R738–744.

    PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., McEwen, B.S., and Spencer, R.L. (1993). Stress response, adrenal steroid receptor levels, and corticosteroid-binding globulin levels—a comparison between Sprague Dawley, Fischer 344, and Lewis rats. Brain Res. 616:89–98.

    Article  PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., Miller, A.H., Stein, M., McEwen, B.S., and Spencer, R.L. (1994). Diurnal and stress-induced changes in distribution of peripheral blood leukocyte subpopulations. Brain Behav. Immun. 8:66–79.

    Article  PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., Miller, A.H., McEwen, B.S., and Spencer, R.L. (1995a). Effects of stress on immune cell distribution—dynamics and hormonal mechanisms. J. Immunol. 154:5511–5527.

    PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., Miller, A.H., McEwen, B.S., and Spencer, R.L. (1995b). Differential activation of adrenal steroid receptors in neural and immune tissues of Sprague Dawley, Fischer 344, and Lewis rats. J. Neuroimmunol. 56:77–90.

    Article  PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., Miller, A.H., McEwen, B.S., and Spencer, R.L. (1996). Stress-induced changes in blood leukocyte distribution—role of adrenal steroid hormones. J. Immunol. 157:1638–1644.

    PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., Satoskar, A.R., Bluethmann, H., David, J.R., and McEwen, B.S. (2000). Stress-induced enhancement of skin immune function: A role for IFNγ. Proc. Natl.Acad. Sci. U.S.A. 97:2846–2851.

    Article  PubMed  CAS  Google Scholar 

  • Dougherty, R.F., and White, A. (1945). Functional alterations in lymphoid tissue induced by adrenal cortical secretion. Am. J. Anatomy 77:81–116.

    Article  Google Scholar 

  • Engler, H., Dawils, L., Hoves, S., Kurth, S., Stevenson, J.R., Schauenstein, K., and

    Google Scholar 

  • Stefanski, V. (2004). Effects of social stress on blood leukocyte distribution: The role of alpha-and beta-adrenergic mechanisms. J. Neuroimmunol. 156: 153–162.

    Article  PubMed  CAS  Google Scholar 

  • Fauci, A.S. (1975). Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and B lymphocytes to the bone marrow. Immunology 28:669–680.

    PubMed  CAS  Google Scholar 

  • Fauci, A.S. (1976). Mechanisms of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone, and dexamethasone on in vitro expression of lymphocyte function. Clin. Exp. Immunol. 24: 54–62.

    PubMed  CAS  Google Scholar 

  • Fauci, A.S., and Dale, D.C. (1974). The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J. Clin. Invest. 53:240–246.

    Article  PubMed  CAS  Google Scholar 

  • Fauci, A.S., and Dale, D.C. (1975). The effect of hydrocortisone on the kinetics of normal human lymphocytes. Blood 46:235–243.

    PubMed  CAS  Google Scholar 

  • Garg, A., Chren, M.M., Sands, L.P., Matsui, M.S., Marenus, K.D., Feingold, K.R., and Elias, P.M. (2001). Psychological stress perturbs epidermal permeability barrier homeostasis: Implications for the pathogenesis of stress-associated skin disorders. Arch. Dermatol. 137:53–59.

    PubMed  CAS  Google Scholar 

  • Goebel, M.U., and Mills, P.J. (2000). Acute psychological stress and exercise and changes in peripheral leukocyte adhesion molecule expression and density. Psychosom. Med. 62:664–670.

    PubMed  CAS  Google Scholar 

  • Goldstein, D.S., and McEwen, B. (2002). Allostasis, homeostats, and the nature of stress. Stress 5:55–58.

    Article  PubMed  Google Scholar 

  • Harris, T.J., Waltman, T.J., Carter, S.M., and Maisel, A.S. (1995). Effect of prolonged catecholamine infusion on immunoregulatory function: Implications in congestive heart failure. J. Am. Coll. Cardiol. 26:102–109.

    Article  PubMed  CAS  Google Scholar 

  • Herbert, T.B., and Cohen, S. (1993). Stress and immunity in humans: A metaanalytic review. Psychosom. Med. 55:364–379.

    PubMed  CAS  Google Scholar 

  • Hirata, F. (1989). The role of lipocortins in cellular function as a second messenger of glucocorticoids. In R.P. Schleimer, H.N. Claman, and A. Oronsky (eds.), Anti-inflammatory Steroid action—Basic and Clinical Aspects. San Diego: Academic Press, pp. 67–95.

    Google Scholar 

  • Hoagland, H., Elmadjian, F., and Pincus, G. (1946). Stressful psychomotor performance and adrenal cortical function as indicated by the lymphocyte reponse. J. Clin. Endocrinol. 6:301–311.

    Article  Google Scholar 

  • Irwin, M., Patterson, T., Smith, T.L., Caldwell, C., Brown, S.A., Gillin, C.J., and Grant, I. (1990). Reduction of immune function in life stress and depression. Biol. Psychiatry 27:22–30.

    Article  PubMed  CAS  Google Scholar 

  • Jensen, M.M. (1969). Changes in leukocyte counts associated with various stressors. J. Reticuloendothelial Soc. 8:457–465.

    Google Scholar 

  • Kok-van Alphen, C.C., and Volker-Dieben, H.J. (1983). Emotional stress and rejection, cause and effect. Doc. Ophthalmol. 56:171–175.

    Article  Google Scholar 

  • Landmann, R. (1992). Beta-adrenergic receptors in human leukocyte subpopulations. Eur. J. Clin. Invest. 22(Suppl. 1):30–36.

    PubMed  Google Scholar 

  • Landmann, R., Muller, F.B., Perini, C.H., Wesp, M., Erne, P., and Buhler, F.R. (1984). Changes of immunoregulatory cells induced by psychological and physical stress: Relationship to plasma catecholamines. Clin. Exp. Immunol. 58:127–135.

    PubMed  CAS  Google Scholar 

  • Lyte, M., Nelson, S.G., and Thompson, M.L. (1990). Innate and adaptive immune responses in a social conflict paradigm. Clin. Immunol. Immunopathol. 57:137–147.

    Article  PubMed  CAS  Google Scholar 

  • Manuck, S.B., Cohen, S., Rabin, B.S., Muldoon, M.F., and Bachen, E.A. (1991). Individual differences in cellular immune response to stress. Psychol. Sci. 2:111–115.

    Article  Google Scholar 

  • McEwen, B.S. (1998). Protective and damaging effects of stress mediators: Allostasis and allostatic load. N. Engl. J. Med. 338:171–179.

    Article  PubMed  CAS  Google Scholar 

  • McEwen, B.S. (2002). The end of stress as we know it. Washington, DC: Dana Press, p. 239.

    Google Scholar 

  • Miller, A.H., Spencer, R.L., Stein, M., and McEwen, B.S. (1990). Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone. Am. J. Physiol. 259:E405–E412.

    PubMed  CAS  Google Scholar 

  • Miller, A.H., Spencer, R.L., Stein, M., and McEwen, B.S. (1991). Adrenal steroid receptor activation in vivo and immune function. Am. J. Physiol. 261:E126–E131.

    PubMed  CAS  Google Scholar 

  • Miller, A.H., Spencer, R.L., Hasset, J., Kim, C.H., Husain, A., McEwen, B.S., and Stein, M. (1992). Type I and type II adrenal steroid receptor agonists have selective effects on peripheral blood immune cells in the rat. Annual Meeting of the Society for Neuroscience Publishers: Society for Neuroscience, Washington, DC Abst. 424.9, Annaheim, CA, p. 1010 (Abstract).

    Google Scholar 

  • Miller, A.H., Spencer, R.L., Husain, A., Rhee, R., McEwen, B.S., and Stein, M. (1993). Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone. Endocrinology 133:2133–2139.

    Article  PubMed  CAS  Google Scholar 

  • Miller, A.H., Spencer, R.L., Hasset, J., Kim, C., Rhee, R., Cira, D., Dhabhar, F.S., McEwen, B.S., and Stein, M. (1994). Effects of selective type I and type II adrenal steroid receptor agonists on immune cell distribution. Endocrinology 135: 1934–1944.

    Article  PubMed  CAS  Google Scholar 

  • Mills, P.J., and Dimsdale, J.E. (1996). The effects of acute psychologic stress on cellular adhesion molecules. J. Psychosom. Res. 41:49–53.

    Article  PubMed  CAS  Google Scholar 

  • Mills, P.J., Berry, C.C., Dimsdale, J.E., Ziegler, M.G., Nelesen, R.A., and Kennedy, B.P. (1995). Lymphocyte subset redistribution in response to acute experimental stress: Effects of gender, ethnicity, hypertension, and the sympathetic nervous system. Brain Behav. Immun. 9:61–69.

    Article  PubMed  CAS  Google Scholar 

  • Mills, P.J., Ziegler, M.G., Rehman, J., and Maisel, A.S. (1998). Catecholamines, catecholamine receptors, cell adhesion molecules, and acute stressor-related changes in cellular immunity. Adv. Pharmacol. 42:587–590.

    Article  PubMed  CAS  Google Scholar 

  • Mills, P.J., Meck, J.V., Waters, W.W., D’Aunno, D., and Ziegler, M.G. (2001). Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosom. Med. 63:886–890.

    PubMed  CAS  Google Scholar 

  • Monjan, A.A., and Collector, M.I. (1977). Stress-induced modulation of the immune response. Science 196:307–308.

    Article  PubMed  CAS  Google Scholar 

  • Morrow-Tesch, J.L., McGlone, J.J., and Norman, R.L. (1993). Consequences of restraint stress on natural killer cell activity, behavior, and hormone levels in Rhesus Macaques (Macaca mulatta). Psychoneuroendocrinology 18:383–395.

    Article  PubMed  CAS  Google Scholar 

  • Munck, A., Guyre, P.M., and Holbrook, N.J. (1984). Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5:25–44.

    Article  PubMed  CAS  Google Scholar 

  • Naliboff, B.D., Benton, D., Solomon, G.F., Morley, J.E., Fahey, J.L., Bloom, E.T., Makinodan, T., and Gilmore, S.L. (1991). Immunological changes in young and old adults during brief laboratory stress. Psychosom. Med. 53:121–132.

    PubMed  CAS  Google Scholar 

  • Onsrud, M., and Thorsby, E. (1981). Influence of in vivo hydrocortisone on some human blood lymphocyte subpopulations. Scand. J. Immunol. 13:573–579.

    Article  PubMed  CAS  Google Scholar 

  • Pickford, G.E., Srivastava, A.K., Slicher, A.M., and Pang P.K.T. (1971). The stress response in the abundance of circulating leukocytes in the Killifish, Fundulus heteroclitus. I The cold-shock sequence and the effects of hypophysectomy. J. Exp. Zool. 177:89–96.

    Article  PubMed  CAS  Google Scholar 

  • Pos, O., Van Dijk, W., Ladiges, N., Linthorst, C., Sala, M., Van Tiel, D., and Boers, W. (1988). Glycosylation of four acute-phase glycoproteins secreted by rat liver cells in vivo and in vitro. Effects of inflammation and dexamethasone. Eur. J. Cell Biol. 46:121–128.

    PubMed  CAS  Google Scholar 

  • Pruett, S.B. (2001). Quantitative aspects of stress-induced immunomodulation. Int. Immunopharmacol. 1:507–520.

    Article  PubMed  CAS  Google Scholar 

  • Redwine, L., Snow, S., Mills, P., and Irwin, M. (2003). Acute psychological stress: Effects on chemotaxis and cellular adhesion molecule expression. Psychosom. Med. 65:598–603.

    Article  PubMed  CAS  Google Scholar 

  • Redwine, L., Mills, P.J., Sada, M., Dimsdale, J., Patterson, T., and Grant, I. (2004). Differential immune cell chemotaxis responses to acute psychological stress in Alzheimer caregivers compared to non-caregiver controls. Psychosom. Med. 66: 770–775.

    Article  PubMed  Google Scholar 

  • Rinder, C.S., Mathew, J.P., Rinder, H.M., Tracey, J.B., Davis, E., and Smith, B.R. (1997). Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender [see comments]. J. Lab. Clin. Med. 129:592–602.

    Article  PubMed  CAS  Google Scholar 

  • Rinner, I., Schauenstein, K., Mangge, H., Porta, S., and Kvetnansky, R. (1992). Opposite effects of mild and severe stress on in vitro activation of rat peripheral blood lymphocytes. Brain Behav. Immun. 6:130–140.

    Article  PubMed  CAS  Google Scholar 

  • Saint-Mezard, P., Chavagnac, C., Bosset, S., Ionescu, M., Peyron, E., Kaiserlian, D., Nicolas, J.F., and Berard, F. (2003). Psychological stress exerts an adjuvant effect on skin dendritic cell functions in vivo. J. Immunol. 171(8):4073–4080.

    PubMed  CAS  Google Scholar 

  • Sapolsky, R.M. (2004). Why zebras don’t get ulcers. New York: W.H. Freeman and Company, p. 560.

    Google Scholar 

  • Sapolsky, R.M. (2005). The influence of social hierarchy on primate health. Science 308:648–652.

    Article  PubMed  CAS  Google Scholar 

  • Schedlowski, M., Jacobs, R., Stratman, G., Richter, S., HÄdike, A., Tewes, U., Wagner, T.O.F., and Schmidt, R.E. (1993a). Changes of natural killer cells during acute psychological stress. J. Clin. Immunol. 13:119–126.

    Article  PubMed  CAS  Google Scholar 

  • Schedlowski, M., Falk, A., Rohne, A., Wagner, T.O.F., Jacobs, R., Tewes, U., and Schmidt, R.E. (1993b). Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells. J. Clin. Immunol. 13:344–351.

    Article  PubMed  CAS  Google Scholar 

  • Schwab, C.L., Fan, R., Zheng, Q., Myers, L.P., Hebert, P., and Pruett, S.B. (2005). Modeling and predicting stress-induced immunosuppression in mice using blood parameters. Toxicol. Sci. 83:101–113.

    Article  PubMed  CAS  Google Scholar 

  • Shephard, R.J. (2003). Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise. Sports Med. 33:261–284.

    Article  PubMed  Google Scholar 

  • Snow, D.H., Ricketts, S.W., and Mason, D.K. (1983). Hematological responses to racing and training exercise in thoroughbred horses, with particular reference to the leukocyte response. Equine Vet. J. 15:149–154.

    Article  PubMed  CAS  Google Scholar 

  • Spain, D.M., and Thalhimer, W (1951). Temporary accumulation of eosinophilic leucocytes in spleen on mice following administration of cortisone. Proc. Soc. Exp. Biol. Med. 76:320–322.

    PubMed  CAS  Google Scholar 

  • Spencer, R.L., Young, E.A., Choo, P.H., and McEwen, B.S. (1990). Adrenal steroid type I and type II receptor binding: Estimates of in vivo receptor number, occupancy, and activation with varying level of steroid. Brain Res. 514:37–48.

    Article  PubMed  CAS  Google Scholar 

  • Spencer, R.L., Miller, A.H., Stein, M., and McEwen, B.S. (1991). Corticosterone regulation of type I and type II adrenal steroid receptors in brain, pituitary, and immune tissue. Brain Res. 549:236–246.

    Article  PubMed  CAS  Google Scholar 

  • Spencer, R.L., Miller, A.H., Moday, H., Stein, M., and McEwen, B.S. (1993). Diurnal differences in basal and acute stress levels of type I and type II adrenal steroid receptor activation in neural and immune tissues. Endocrinology 133:1941–1949.

    Article  PubMed  CAS  Google Scholar 

  • Sprent, J., and Tough, D.F. (1994). Lymphocyte life-span and memory. Science 265: 1395–1400.

    Article  PubMed  CAS  Google Scholar 

  • Spry, C.J.F. (1972). Inhibition of lymphocyte recirculation by stress and corticotropin. Cell Immunol. 4:86–92.

    Article  PubMed  CAS  Google Scholar 

  • Stefanski, V. (2003). Social stress affects migration of blood T cells into lymphoid organs. J. Neuroimmunol. 138:17–24.

    Article  PubMed  CAS  Google Scholar 

  • Stein, M., Ronzoni, E., and Gildea, E.F. (1951). Physiological responses to heat stress and ACTH of normal and schizophrenic subjects. Am. J. Psychiatry 6: 450–455.

    Google Scholar 

  • Toft, P., Svendsen, P., Tonnesen, E., Rasmussen, J.W., and Christensen, N.J. (1993). Redistribution of lymphocytes after major surgical stress. Acta. Anesthesiol. Scand. 37:245–249.

    Article  CAS  Google Scholar 

  • Tonnesen, E., Christensen, N.J., and Brinklov, M.M. (1987). Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers. Eur. J. Clin. Invest. 17:497–503.

    Article  PubMed  CAS  Google Scholar 

  • Ulich, T.R., Keys, M., Ni, R.X., del Castillo, J., and Dakay, E.B. (1988). The contributions of adrenal hormones, hemodynamic factors, and the endotoxin-related stress reaction to stable prostaglandin analog-induced peripheral lymphopenia and neutrophilia. J. Leukoc. Biol. 43:5–10.

    PubMed  CAS  Google Scholar 

  • Van Den Broek, A.A., Keuning, F.J., Soeharto, R., and Prop, N. (1983). Immune suppression and histophysiology of the immune response I. Cortisone acetate and lymphoid cell migration. Virchows Arch. [Cell Pathol.]. 43:43–54.

    Article  Google Scholar 

  • Viswanathan, K., and Dhabhar, F.S. (2005). Stress-induced enhancement of leukoctetrafficking into sites of surgery or immune activation. Proc. Natl. Acad. Sci. U.S.A. 102:5808–5813.

    Article  PubMed  CAS  Google Scholar 

  • Viswanathan, K., Daugherty, C., and Dhabhar, F.S. (2005). Stress as an endogenous adjuvant: augmentation of the immunization phase of cell-mediated immunity. Int. Immunol. 17:1059–1069.

    Article  PubMed  CAS  Google Scholar 

  • Walzer, P.D., LaBine, M., Redington, T.J., and Cushion, M.T. (1984). Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: Relation to pneumocystis carinii pneumonia. J. Immunol. 133:2502–2508.

    PubMed  CAS  Google Scholar 

  • Zalcman, S., and Anisman, H. (1993). Acute and chronic stressor effects on the antibody response to sheep red blood cells. Pharmacol. Biochem. Behav. 46:445–452.

    Article  PubMed  CAS  Google Scholar 

  • Zalcman, S., Henderson, N., Richter, M., and Anisman, H. (1991). Age-related enhancement and suppression of a T-cell-dependent antibody response following stressor exposure. Behav. Neurosci. 105:669–676.

    Article  PubMed  CAS  Google Scholar 

  • Zatz, M.M. (1975). Effects of cortisone on lymphocyte homing. Isr. J. Med. Sci. 11: 1368–1372.

    CAS  Google Scholar 

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  1. Firdaus S. Dhabhar
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Editors and Affiliations

  1. Departments of Veterinary Integrative Biosciences and Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843-4458

    C. Jane Welsh

  2. Department of Psychology College of Liberal Arts, Texas A&M University, College Station, TX, 77843-4225

    Mary W. Meagher

  3. Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health National Institutes of Health, Rockville, MD, 20892-9401

    Esther M. Sternberg

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Dhabhar, F.S. (2006). Stress-induced Changes in Immune Cell Distribution and Trafficking: Implications for Immunoprotection versus Immunopathology. In: Welsh, C.J., Meagher, M.W., Sternberg, E.M. (eds) Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48334-4_2

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