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Early Postnatal Nongenetic Factors Modulate Disease Susceptibility in Adulthood: Examples from Disease Models of Multiple Sclerosis, Periodontitis, and Asthma

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Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

Abstract

The genesis of individuality serves as an adaptive mechanism and includes the nongenetic modification of several developmental dimensions such as growth, maturation, and learning.As a consequence, modified stress responsiveness, coping strategies, and susceptibility for diseases develop interdependently. Until today, knowledge on the neurobiology of individuality has only marginally been integrated into the understanding of the pathophysiology, prevention, and therapy of diseases.

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Stephan, M., Skripuletz, T., von Hörsten, S. (2006). Early Postnatal Nongenetic Factors Modulate Disease Susceptibility in Adulthood: Examples from Disease Models of Multiple Sclerosis, Periodontitis, and Asthma. In: Welsh, C.J., Meagher, M.W., Sternberg, E.M. (eds) Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48334-4_12

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