Skip to main content

Functional Interaction Between ATP and TRPV1 Receptors

  • Chapter
Molecular Sensors for Cardiovascular Homeostasis
  • 866 Accesses

Abstract

Noxious thermal, mechanical, or chemical stimuli evoke pain through excitation of the peripheral terminals called nociceptors.1,2 Many kinds of ionotropic and metabotropic receptors are involved in this process. TRPV1, a capsaicin receptor, is a nociceptor-specific ion channel that serves as the molecular target of capsaicin, having six transmembrane domains with a short hydrophobic stretch between the fifth and sixth transmembrane domains.7

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fields, H.L., 1987, Pain, McGraw-Hill, New York.

    Google Scholar 

  2. Wood, J.N., and Perl, E.R., 1999, Pain. Curr. Opin. Genet. Dev. 9: 328–332.

    Article  CAS  Google Scholar 

  3. Cesare, P., and McNaughton, P., 1997, Peripheral pain mechanisms, Curr. Opin. Neurobiol. 7: 493–499.

    Article  PubMed  CAS  Google Scholar 

  4. Julius, D., and Basbaum, A.I., 2001, Molecular mechanisms of nociception, Nature 413: 203–210.

    Article  PubMed  CAS  Google Scholar 

  5. McCleskey, E.W., and Gold, M.S., 1999, Ion channels of nociception, Annu. Rev. Physiol. 61: 835–856.

    Article  PubMed  CAS  Google Scholar 

  6. Scholz, J., and Woolf, C.J., 2002, Can we conquer pain? Nat. Neurosci. 5 Suppl: 1062–1067.

    Google Scholar 

  7. Caterina, M.J., and Julius, D., 2001, The vanilloid receptor: a molecular gateway to the pain pathway, Annu. Rev. Neurosci. 24: 487–517.

    Article  PubMed  CAS  Google Scholar 

  8. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., and Julius, D., 1997, The capsaicin receptor: a heat-activated ion channel in the pain pathway, Nature 389: 816–824.

    Article  PubMed  CAS  Google Scholar 

  9. Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Basbaum, A.I., and Julius, D., 1998, The cloned capsaicin receptor integrates multiple pain-producing stimuli, Neuron 21: 531–543.

    Article  PubMed  CAS  Google Scholar 

  10. Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I., and Julius, D., 2000, Impaired nociception and pain sensation in mice lacking the capsaicin receptor, Science 288: 306–313.

    Article  PubMed  CAS  Google Scholar 

  11. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K., et al., 2000, Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia, Nature 405: 183–187.

    Article  PubMed  CAS  Google Scholar 

  12. Bodin, P., and Burnstock, G., 2001, Purinergic signalling: ATP release, Neurochem, Res, 26:959–969.

    Article  CAS  Google Scholar 

  13. Burnstock, G., 2001, Purine-mediated signalling in pain and visceral perception, Trends Pharmacol. Sci. 22: 182–188.

    Article  PubMed  CAS  Google Scholar 

  14. Burnstock, G., 1999, Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction, J. Anat, 194(Pt 3): 335–342.

    Article  PubMed  CAS  Google Scholar 

  15. Vassort, G., 2001, Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium, Physiol. Rev. 81: 767–806.

    PubMed  CAS  Google Scholar 

  16. Forrester, T., and Williams, C.A., 1977, Release of adenosine triphosphate from isolated adult heart cells in response to hypoxia, J. Physiol. 268: 371–390.

    PubMed  CAS  Google Scholar 

  17. Pearson, J.D., and Gordon, J.L., 1985, Nucleotide metabolism by endothelium, Annu. Rev. Physiol. 47: 617–627.

    Article  PubMed  CAS  Google Scholar 

  18. North, R.A., and Barnard, E.A., 1997, Nucleotide receptors, Curr. Opin. Neurobiol. 7: 346–357.

    Article  PubMed  CAS  Google Scholar 

  19. Ralevic, V., and Burnstock, G., 1998, Receptors for purines and pyrimidines, Pharmacol. Rev. 50: 413–492.

    PubMed  CAS  Google Scholar 

  20. Chen, C.C., Akopian, A.N., Sivilotti, L., Colquhoun, D., Burnstock, G., and Wood, J.N., 1995, A P2X purinoceptor expressed by a subset of sensory neurons, Nature 377: 428–431.

    Article  PubMed  CAS  Google Scholar 

  21. Lewis, C., Neidhart, S., Holy, C., North, R.A., Buell, G., and Surprenant, A., 1995, Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons, Nature 377: 432–435.

    Article  PubMed  CAS  Google Scholar 

  22. Tominaga, M., Wada, M., and Masu, M., 2001, Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia, Proc. Natl. Acad. Sci. USA 98: 6951–6956.

    Article  PubMed  CAS  Google Scholar 

  23. Numazaki, M., Tominaga, T., Toyooka, H., and Tominaga, M., 2002, Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues, J. Biol. Chem. 277: 13375–13378.

    Article  PubMed  CAS  Google Scholar 

  24. Moriyama, T., Iida, T., Kobayashi, K., Higashi, T., Fukuoka, T., Tsumura, H., Leon, C., Suzuki, N., Inoue, K., Gachet, C., et al., 2003, Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity, J. Neurosci. 23: 6058–6062.

    PubMed  CAS  Google Scholar 

  25. Anderson, C.M., and Parkinson, F.E., 1997, Potential signalling roles for UTP and UDP: sources, regulation, and release of uracil nucleotides, Trends Pharmacol, Sci, 18: 387–392.

    CAS  Google Scholar 

  26. Lazarowski, E.R., Boucher, R.C., and Harden, T.K., 2000, Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations, J. Biol. Chem. 275: 31061–31068.

    Article  PubMed  CAS  Google Scholar 

  27. Sawynok, J., and Sweeney, M.I., 1989, The role of purines in nociception, Neuroscience 32: 557–569.

    Article  PubMed  CAS  Google Scholar 

  28. Molliver, D.C., Cook, S.P., Carlsten, J.A., Wright, D.E., and McCleskey, E.W., 2002, ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2, Eur. J. Neurosci. 16: 1850–1860.

    Article  PubMed  Google Scholar 

  29. Zimmermann, K., Reeh, P.W., and Averbeck, B., 2002, ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater, Pain 97: 259–265.

    Article  PubMed  CAS  Google Scholar 

  30. Mizumura, K., and Kumazawa, T., 1996, Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action—a study in canine testicular polymodal receptors, Prog. Brain Res. 113: 115–141.

    Article  PubMed  CAS  Google Scholar 

  31. Sugiura, T., Tominaga, M., Katsuya, H., and Mizumura, K., 2002, Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1, J. Neurophysiol. 88: 544–548.

    PubMed  CAS  Google Scholar 

  32. Vergnolle, N., Wallace, J.L., Bunnett, N.W., and Hollenberg, M.D., 2001, Protease-activated receptors in inflammation, neuronal signaling, and pain, Trends Pharmacol. Sci. 22: 146–152.

    Article  PubMed  CAS  Google Scholar 

  33. Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G.S., Grady, E.F., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J.A., Ennes, H., et al., 2004, Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloids receptor 1 to induce hyperalgesia, J. Neurosci. 24: 4300–4312.

    Article  PubMed  CAS  Google Scholar 

  34. Dai, Y., Moriyama, T., Higashi, T., Togashi, K., Kobayashi, K., Yamanaka, H., Tominaga, M., and Noguchi, K., 2004, Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloids subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain, J. Neurosci. 24: 4293–4299.

    Article  PubMed  CAS  Google Scholar 

  35. Chuang, H.H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., and Julius, D., 2001, Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition, Nature 411: 957–962.

    Article  PubMed  CAS  Google Scholar 

  36. Prescott, E.D., and Julius, D., 2003, A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity, Science 300: 1284–1288.

    Article  PubMed  CAS  Google Scholar 

  37. Ahern, G.P., 2003, Activation of TRPV1 by the satiety factor oleoylethanolamide, J. Biol. Chem. 278: 30429–30434.

    Article  PubMed  CAS  Google Scholar 

  38. Huang, S.M., Bisogno, T., Trevisani, M., Al-Hayani, A., De Petrocellis, L., Fezza, F., Tognetto, M., Petros, T.J., Krey, J.F., Chu, C.J., et al., 2002, An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors, Proc. Natl. Acad. Sci. USA 99: 8400–8405.

    Article  PubMed  CAS  Google Scholar 

  39. Hwang, S.W., Cho, H., Kwak, J., Lee, S.Y., Kang, C.J., Jung, J., Cho, S., Min, K.H., Suh, Y.G., Kim, D., and Oh, U., 2000, Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances, Proc. Natl. Acad. Sci. USA 97: 6155–6160.

    Article  PubMed  CAS  Google Scholar 

  40. Zygmunt, P.M., Petersson, J., Andersson, D.A., Chuang, H., Sorgard, M., Di Marzo, V., Julius, D., and Hogestatt, E.D., 1999, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide, Nature 400: 452–457.

    Article  PubMed  CAS  Google Scholar 

  41. Shin, J., Cho, H., Hwang, S.W., Jung, J., Shin, C.Y., Lee, S.Y., Kim, S.H., Lee, M.G., Choi, Y.H., Kim, J., et al., 2002, Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia, Proc. Natl. Acad. Sci. USA 99: 10150–10155.

    Article  PubMed  CAS  Google Scholar 

  42. Coleridge, H.M., and Coleridge, J.C., 1980, Cardiovascular afferents involved in regulation of peripheral vessels, Annu. Rev. Physiol. 42: 413–427.

    Article  PubMed  CAS  Google Scholar 

  43. Malliani, A., Lombardi, F., and Pagani, M., 1981, Functions of afferents in cardiovascular sympathetic nerves, J. Auton. Nerv. Syst. 3: 231–236.

    Article  PubMed  CAS  Google Scholar 

  44. Moskowitz, M.A., 1990, Basic mechanisms in vascular headache, Neurol. Clin. 8: 801–815.

    PubMed  CAS  Google Scholar 

  45. Benson, C.J., Eckert, S.P., and McCleskey, E.W., 1999, Acid-evoked currents in cardiac sensory neurons: a possible mediator of myocardial ischemic sensation, Circ, Res, 24: 921–928.

    Google Scholar 

  46. Vaishnava, P., and Wang, D.H., 2003, Capsaicin sensitive-sensory nerves and blood pressure regulation, Curr. Med. Chem. Cardiovasc. Hematol. Agents 1: 177–188.

    Article  PubMed  CAS  Google Scholar 

  47. Burnstock, G., 2002, Purinergic signalling and vascular cell proliferation and death, Arterioscler. Thromb. Vasc. Bio 22: 364–373.

    Article  CAS  Google Scholar 

  48. Kunapuli, S.P., and Daniel, J.L., 1998, P2 receptor subtypes in the cardiovascular system, Biochem. J. 336 (Pt 3): 513–523.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Tominaga, M., Moriyama, T. (2007). Functional Interaction Between ATP and TRPV1 Receptors. In: Wang, D.H. (eds) Molecular Sensors for Cardiovascular Homeostasis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-47530-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-47530-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-47528-8

  • Online ISBN: 978-0-387-47530-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics