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Molecular Transfers through Transient Lymphoid Cell-Cell Channels

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Cell-Cell Channels

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Abstract

Intercellular communication is inherent to life and has evolved with extremely diversified forms from prokaryotes to the most sophisticated multicellular eukaryotes. Haematopoietic cells from mammalians have adapted a transient and highly versatile means for the direct transfer of molecular information through cell-cell channels. This channel takes place and operates transiently at a highly specialised interface now referred to as the immunological synapse. The oriented transfer of membrane molecules from one cell to another is now referred to as trogocytosis, a cell process discovered recently, but which consequences have been described for decades without clear understanding of its cellular basis. This article will review current state-of-the-art knowledge on trogocytosis, its technological use and physiological significance.

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Authors and Affiliations

  1. Groupe d’Etude des Antigènes NonConventionnels, département Oncogénèse & Signalisation dans les Cellules Hématopoiétiques, INSERM Unité 563, Centre de Physiopathologie de Toulouse Purpan, Centre de Physiopathologie de Toulouse Purpan, Hôpital Purpan, BP3048, 31024, Toulouse Cedex 03, France

    Mary Poupot, Julie Gertner & Jean-Jacques Fournié

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  1. Mary Poupot
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  2. Julie Gertner
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  3. Jean-Jacques Fournié
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Correspondence to Jean-Jacques Fournié .

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Poupot, M., Gertner, J., Fournié, JJ. (2006). Molecular Transfers through Transient Lymphoid Cell-Cell Channels. In: Cell-Cell Channels. Springer, New York, NY. https://doi.org/10.1007/978-0-387-46957-7_20

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