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Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst

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Book cover Cell-Cell Channels

Abstract

In most animal species, female and male gametes are produced within clusters of germ cells which share a common cytoplasm through cell-cell channels. In Drosophila ovaries, these cells synchronise their divisions and specialise one cell of the cluster as the future egg. Both processes are organised by a germline-specific organelle of communication called the fusome. Until recently, the fusome has remained largely mysterious despite a hundred years of research on its composition, formation and functions. Novel results have now suggested several molecular mechanisms to explain how the fusome synchronises the divisions by controlling cell-cycle regulators and how it determines and polarises the future egg by organising the microtubule cytoskeleton. Importantly, a structure similar to the fusome has been identified during Xenopus oogenesis, suggesting that it is widely conserved from invertebrates to vertebrates, and that it thus serves an essential function.

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  1. Institut Jacques-Monod, CNRS, Universités Paris, 6 et 7, 2, place Jussieu, F-75251, Paris Cedex 05, France

    Jean-René Huynh

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Huynh, JR. (2006). Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst. In: Cell-Cell Channels. Springer, New York, NY. https://doi.org/10.1007/978-0-387-46957-7_16

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