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Chaperones as Parts of Cellular Networks

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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 594))

Abstract

The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. Molecular chaperones usually have many first and second neighbors in protein-protein interaction networks and they play a prominent role in signaling and transcriptional regulatory networks of the cell. Chaperones may uncouple protein, signaling, membranous, organellar and transcriptional networks during stress, which gives an additional protection for the cell at the network-level. Recent advances uncovered that chaperones act as genetic buffers stabilizing the phenotype of various cells and organisms. This chaperone effect on the emergent properties of cellular networks may be generalized to proteins having a specific, central position and low affinity, weak links in protein networks. Cellular networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies.

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Author information

Authors and Affiliations

  1. Department of Medical Chemistry, Semmelweis University, Puskin Street 9, H-1088, Budapest, Hungary

    Peter Csermely & Csaba Söti

  2. Chaperone Research Group Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa

    Gregory L. Blatch

Authors
  1. Peter Csermely
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  2. Csaba Söti
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  3. Gregory L. Blatch
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Corresponding author

Correspondence to Peter Csermely .

Editor information

Editors and Affiliations

  1. Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

    Peter Csermely

  2. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    László Vígh

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© 2007 Landes Bioscience and Springer Science+Business Media

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Csermely, P., Söti, C., Blatch, G.L. (2007). Chaperones as Parts of Cellular Networks. In: Csermely, P., Vígh, L. (eds) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Advances in Experimental Medicine and Biology, vol 594. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39975-1_6

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